# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4768213 | Functional | Induction of cell membrane damage in Escherichia coli ATCC 25922 assessed as fluorescence emission at MIC after 1 hr by propidium iodide staining based transmission electron microscopy (Rvb = 4.34%) | Escherichia coli | 1 | ALA4765269 | subcellular format | Scientific Literature | |
2. | ALA4768214 | Functional | Antibacterial activity against Escherichia coli ATCC 25922 assessed as inhibition of growth measured after 24 hrs by CLSI based broth microdilution method | Escherichia coli | 25 | ALA4765269 | organism-based format | Scientific Literature | |
3. | ALA4768215 | Functional | Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as inhibition of growth measured after 24 hrs by CLSI based broth microdilution method | Staphylococcus aureus | 25 | ALA4765269 | organism-based format | Scientific Literature | |
4. | ALA4768216 | Toxicity | Toxicity in rabbit red blood cells assessed as hemolysis at 3 to 22.5 ug/ml incubated for 1 hr relative to control | Oryctolagus cuniculus | 1 | ALA4765269 | cell-based format | Scientific Literature | |
5. | ALA4768217 | Functional | Antibacterial activity against Escherichia coli ATCC 25922 assessed as bacterial growth inhibition at 0.5 times of MIC concentration measured at logarithmic phase 6 th hr of bacterial cycle | Escherichia coli | 1 | ALA4765269 | organism-based format | Scientific Literature | |
6. | ALA4768218 | Functional | Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as bacterial growth inhibition at 0.5 times of MIC concentration measured at logarithmic phase 6 th hr of bacterial cycle | Staphylococcus aureus | 1 | ALA4765269 | organism-based format | Scientific Literature | |
7. | ALA4768219 | Functional | Induction of morphological changes in Escherichia coli ATCC 25922 assessed as deformed, pitted and shriveled surface at MIC incubated for 12 hrs by scanning electron microscopy | Escherichia coli | 1 | ALA4765269 | organism-based format | Scientific Literature | |
8. | ALA4768220 | Functional | Induction of morphological changes in Staphylococcus aureus ATCC 29213 assessed as deformed, pitted and shriveled surface at MIC incubated for 12 hrs by scanning electron microscopy | Staphylococcus aureus | 1 | ALA4765269 | organism-based format | Scientific Literature | |
9. | ALA4768221 | Functional | Induction of morphological changes in Escherichia coli ATCC 25922 assessed as damaged cells at MIC incubated for 12 hrs by Transmission electron microscopy | Escherichia coli | 1 | ALA4765269 | organism-based format | Scientific Literature | |
10. | ALA4768222 | Functional | Induction of morphological changes in Staphylococcus aureus ATCC 29213 assessed as damaged cells at MIC incubated for 12 hrs by Transmission electron microscopy | Staphylococcus aureus | 1 | ALA4765269 | organism-based format | Scientific Literature | |
11. | ALA4768223 | Functional | Induction of membrane disruption in Escherichia coli ATCC 25922 at 1 to 4 x MIC measured within 20 min by Ethidium bromide based fluorescence assay | Escherichia coli | 1 | ALA4765269 | subcellular format | Scientific Literature | |
12. | ALA4768224 | Functional | Induction of membrane disruption in Staphylococcus aureus ATCC 29213 at 1 to 4 x MIC measured within 20 min by Ethidium bromide based fluorescence assay | Staphylococcus aureus | 1 | ALA4765269 | subcellular format | Scientific Literature | |
13. | ALA4768225 | Functional | Induction of cell membrane damage in Staphylococcus aureus ATCC 29213 assessed as fluorescence emission at MIC after 1 hr by propidium iodide staining based transmission electron microscopy (Rvb= 1.53%) | Staphylococcus aureus | 1 | ALA4765269 | subcellular format | Scientific Literature | |
14. | ALA4768226 | Functional | Induction of membrane depolarization in Escherichia coli ATCC 25922 assessed as increased the fluorescence intensity at 1 to 2 times of MIC incubated for 80 min by [DiSC3(5)] probe based fluorescence assay | Escherichia coli | 1 | ALA4765269 | subcellular format | Scientific Literature | |
15. | ALA4768227 | Functional | Induction of membrane depolarization in Staphylococcus aureus ATCC 29213 assessed as increased the fluorescence intensity at 1 to 2 times of MIC incubated for 80 min by [DiSC3(5)] probe based fluorescence assay | Staphylococcus aureus | 1 | ALA4765269 | subcellular format | Scientific Literature | |
16. | ALA4768228 | Functional | Antibacterial activity against Staphylococcus aureus ATCC 29213 infected in mouse C57BL/6 bacterimia model assessed as reduction in number of viable pathogens in peritoneal cavity at 12 mg/kg, ip treated 1 hr after infection measured after 24 hrs | Staphylococcus aureus | 1 | ALA4765269 | organism-based format | Scientific Literature | |
17. | ALA4768229 | Functional | Antibacterial activity against Staphylococcus aureus ATCC 29213 infected in mouse C57BL/6 bacterimia model assessed as reduction in number of viable pathogens in peritoneal cavity at 24 mg/kg, ip treated 1 hr after infection measured after 24 hrs | Staphylococcus aureus | 1 | ALA4765269 | organism-based format | Scientific Literature | |
18. | ALA4768230 | Functional | Antibacterial activity against Escherichia coli ATCC 25922 assessed as bacterial growth inhibition at 1 to 2 times of MIC concentration measured at logarithmic phase 6 th hr of bacterial cycle | Escherichia coli | 1 | ALA4765269 | organism-based format | Scientific Literature | |
19. | ALA4768231 | Functional | Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as bacterial growth inhibition at 1 to 2 times of MIC concentration measured at logarithmic phase 6 th hr of bacterial cycle | Staphylococcus aureus | 1 | ALA4765269 | organism-based format | Scientific Literature |