# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4714733 | B | Binding affinity to wild-type human partial length TAK1 (M1 to Q303 residues) expressed in mammalian expression system by Kinomescan method | Homo sapiens | 1 | ALA4706727 | assay format | Scientific Literature | |
2. | ALA4714734 | P | Aqueous solubility of compound in pH 7.4 PBS buffer measured after 24 hrs by HPLC-UV analysis | 2 | ALA4706727 | small-molecule physicochemical format | Scientific Literature | ||
3. | ALA4714735 | A | Half life in human liver S9 fraction at 1 uM measured up to 60 mins in presence of NADPH by LC-MS analysis | Homo sapiens | 2 | ALA4706727 | subcellular format | Scientific Literature | |
4. | ALA4714736 | A | Half life in CD-1 mouse liver S9 fraction at 1 uM measured up to 60 mins in presence of NADPH by LC-MS analysis | Mus musculus | 2 | ALA4706727 | subcellular format | Scientific Literature | |
5. | ALA4714737 | A | Half life in rat liver S9 fraction at 1 uM measured up to 60 mins in presence of NADPH by LC-MS analysis | Rattus norvegicus | 2 | ALA4706727 | subcellular format | Scientific Literature | |
6. | ALA4714738 | A | Apparent permeability across apical to basolateral side in human Caco-2 cells at 2 uM after 2 hrs by LC/MS-MS analysis | Homo sapiens | 2 | ALA4706727 | cell-based format | Scientific Literature | |
7. | ALA4714739 | A | Apparent permeability across basolateral to apical side in human Caco-2 cells at 2 uM after 2 hrs by LC/MS-MS analysis | Homo sapiens | 2 | ALA4706727 | cell-based format | Scientific Literature | |
8. | ALA4714740 | A | Efflux ratio of apparent permeability across basolateral to apical side over apical to basolateral side in human Caco-2 cells at 2 uM after 2 hrs by LC/MS-MS analysis | Homo sapiens | 1 | ALA4706727 | cell-based format | Scientific Literature | |
9. | ALA4714741 | B | Inhibition of human ABL1 H396P mutant (S229 to K512 residues) expressed in mammalian expression system at 10 uM by kinomescan method relative to control | Homo sapiens | 1 | ALA4706727 | assay format | Scientific Literature | |
10. | ALA4714742 | B | Inhibition of wild-type human partial length EIF2AK1 (Q147 to E603 residues) expressed in mammalian expression system at 10 uM by Kinomescan method relative to control | Homo sapiens | 1 | ALA4706727 | assay format | Scientific Literature | |
11. | ALA4714743 | B | Inhibition of wild-type human partial length TNK2 (S159 to D474 residues) expressed in bacterial expression system at 10 uM by Kinomescan method relative to control | Homo sapiens | 1 | ALA4706727 | assay format | Scientific Literature | |
12. | ALA4714744 | B | Inhibition of wild-type human full-length YANK1 (M1 to L396 residues) expressed in mammalian expression system at 10 uM by Kinomescan method relative to control | Homo sapiens | 1 | ALA4706727 | assay format | Scientific Literature |