# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4734716 | Functional | Induction of cell cycle arrest in human A-375 cells assessed as accumulation at G0/G1 phase upto 1000 uM incubated for 48 hrs by propidium iodide staining based flow cytometry | Homo sapiens | 1 | ALA4732105 | cell-based format | Scientific Literature | |
2. | ALA4734717 | Functional | Cytotoxicity against mouse B16F10 cells assessed as reduction in cell viability after 72 hrs by MTT assay | Mus musculus | 3 | ALA4732105 | cell-based format | Scientific Literature | |
3. | ALA4734721 | Functional | Cytotoxicity against human A375 cells assessed as reduction in cell viability after 72 hrs by MTT assay | Homo sapiens | 3 | ALA4732105 | cell-based format | Scientific Literature | |
4. | ALA4734722 | Binding | Protac activity at CRBN/CDK2 in mouse B16F10 cells assessed as induction of CDK2 protein degradation after 12 hrs by Western blot analysis | Mus musculus | 1 | ALA4732105 | cell-based format | Scientific Literature | |
5. | ALA4734723 | Binding | Protac activity at CRBN/CDK4 in mouse B16F10 cells assessed as induction of CDK4 protein degradation after 12 hrs by Western blot analysis | Mus musculus | 1 | ALA4732105 | cell-based format | Scientific Literature | |
6. | ALA4734724 | Binding | Protac activity at CRBN/CDK6 in mouse B16F10 cells assessed as induction of CDK6 protein degradation after 12 hrs by Western blot analysis | Mus musculus | 1 | ALA4732105 | cell-based format | Scientific Literature | |
7. | ALA4734725 | Binding | Protac activity at CRBN/CDK2 in human A-375 cells assessed as induction of CDK2 protein degradation after 12 hrs by Western blot analysis | Homo sapiens | 1 | ALA4732105 | cell-based format | Scientific Literature | |
8. | ALA4734726 | Binding | Protac activity at CRBN/CDK4 in human A-375 cells assessed as induction of CDK4 protein degradation after 12 hrs by Western blot analysis | Homo sapiens | 1 | ALA4732105 | cell-based format | Scientific Literature | |
9. | ALA4734727 | Binding | Protac activity at CRBN/CDK6 in human A-375 cells assessed as induction of CDK6 protein degradation after 12 hrs by Western blot analysis | Homo sapiens | 1 | ALA4732105 | cell-based format | Scientific Literature | |
10. | ALA4734728 | Binding | Protac activity at CRBN/CDK2 in mouse B16F10 cells assessed as induction of CDK2 protein degradation at 500 nM by Western blot analysis | Mus musculus | 1 | ALA4732105 | cell-based format | Scientific Literature | |
11. | ALA4734729 | Binding | Protac activity at CRBN/CDK4 in mouse B16F10 cells assessed as induction of CDK4 protein degradation at 500 nM by Western blot analysis | Mus musculus | 1 | ALA4732105 | cell-based format | Scientific Literature | |
12. | ALA4734730 | Binding | Protac activity at CRBN/CDK6 in mouse B16F10 cells assessed as induction of CDK6 protein degradation at 500 nM by Western blot analysis | Mus musculus | 1 | ALA4732105 | cell-based format | Scientific Literature | |
13. | ALA4734731 | Binding | Protac activity at CRBN/CDK2 in human A-375 cells assessed as induction of CDK2 protein degradation at 1000 nM by Western blot analysis | Homo sapiens | 1 | ALA4732105 | cell-based format | Scientific Literature | |
14. | ALA4734732 | Binding | Protac activity at CRBN/CDK4 in human A-375 cells assessed as induction of CDK4 protein degradation at 1000 nM by Western blot analysis | Homo sapiens | 1 | ALA4732105 | cell-based format | Scientific Literature | |
15. | ALA4734733 | Binding | Protac activity at CRBN/CDK6 in human A-375 cells assessed as induction of CDK6 protein degradation at 1000 nM by Western blot analysis | Homo sapiens | 1 | ALA4732105 | cell-based format | Scientific Literature | |
16. | ALA4734734 | Binding | Protac activity at CRBN/CDK2 in mouse B16F10 cells assessed as induction of CDK2 protein degradation at 100 nM for 6 hrs in presence of proteasome inhibitor MG132 by Western blot analysis | Mus musculus | 1 | ALA4732105 | cell-based format | Scientific Literature | |
17. | ALA4734735 | Binding | Protac activity at CRBN/CDK4 in mouse B16F10 cells assessed as induction of CDK4 protein degradation at 100 nM for 6 hrs in presence of proteasome inhibitor MG132 by Western blot analysis | Mus musculus | 1 | ALA4732105 | cell-based format | Scientific Literature | |
18. | ALA4734736 | Binding | Protac activity at CRBN/CDK6 in mouse B16F10 cells assessed as induction of CDK6 protein degradation at 100 nM for 6 hrs in presence of proteasome inhibitor MG132 by Western blot analysis | Mus musculus | 1 | ALA4732105 | cell-based format | Scientific Literature | |
19. | ALA4734737 | Functional | Inhibition of colony formation in mouse B16F10 cells at 50 to 100 nM measured after 7 days by crystal violet staining based colony formation assay | Mus musculus | 1 | ALA4732105 | cell-based format | Scientific Literature | |
20. | ALA4734738 | Functional | Inhibition of colony formation in human A-375 cells at 250 to 500 nM measured after 7 days by crystal violet staining based colony formation assay | Homo sapiens | 1 | ALA4732105 | cell-based format | Scientific Literature |