| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4724801 | F | Antidiabetic activity in po dosed N-STZ 1.5 rat assessed as reduction in GHB level for 4 weeks | Rattus norvegicus | 1 | ALA4715912 | organism-based format | Scientific Literature | |
| 2. | ALA4724802 | F | Antidiabetic activity in po dosed N-STZ 1.5 rat assessed as reduction in glucose level pre-treated for 60 mins followed by 1.5 g/kg glucose treatment and measured up to 120 mins by OGTT | Rattus norvegicus | 1 | ALA4715912 | organism-based format | Scientific Literature | |
| 3. | ALA4724803 | F | Antidiabetic activity in N-STZ 1.5 rat assessed as increase in plasma insulin level at 1 to 3 mg/kg, po pre-treated for 60 mins followed by 1.5 g/kg glucose treatment and measured up to 120 mins by radioimmunoassay | Rattus norvegicus | 1 | ALA4715912 | organism-based format | Scientific Literature | |
| 4. | ALA4724804 | F | Antidiabetic activity in N-STZ 1.5 rat assessed as reduction in glucose level at 1 mg/kg, po pre-treated for 60 mins followed by 1.5 g/kg glucose treatment and measured up to 120 mins by OGTT | Rattus norvegicus | 1 | ALA4715912 | organism-based format | Scientific Literature | |
| 5. | ALA4724805 | A | MRT in rat at 1 mg/kg, po by LC/MS/MS analysis | Rattus norvegicus | 1 | ALA4715912 | organism-based format | Scientific Literature | |
| 6. | ALA4724806 | A | Oral bioavailability in rat at 1 mg/kg by LC/MS/MS analysis | Rattus norvegicus | 1 | ALA4715912 | organism-based format | Scientific Literature | |
| 7. | ALA4724807 | A | AUC in rat at 1 mg/kg, po by LC/MS/MS analysis | Rattus norvegicus | 1 | ALA4715912 | organism-based format | Scientific Literature | |
| 8. | ALA4724808 | A | Volume of distribution at steady state in rat at 0.1 mg/kg, iv by LC/MS/MS analysis | Rattus norvegicus | 1 | ALA4715912 | organism-based format | Scientific Literature | |
| 9. | ALA4724809 | B | Agonist activity at rat GPR119 expressed in CHO cells co-expressing cyclic AMP response element incubated for 2 hrs by steady-glo luciferase assay | Rattus norvegicus | 1 | ALA4715912 | cell-based format | Scientific Literature | |
| 10. | ALA4724810 | B | Agonist activity at GPR119 in glucose-induced mouse L cells assessed as induction of GLP-1 secretion after 2 hrs by ELISA | Mus musculus | 1 | ALA4715912 | tissue-based format | Scientific Literature | |
| 11. | ALA4724811 | B | Agonist activity at GPR119 in glucose-induced golden hamster HIT-T15 cells assessed as increase in insulin secretion after 2 hrs by A1phaLISA | Mesocricetus auratus | 1 | ALA4715912 | tissue-based format | Scientific Literature | |
| 12. | ALA4724813 | P | Partition coefficient, logD between 1-octanol and pH 7.4 aqueous buffer by chromatographic analysis | 21 | ALA4715912 | small-molecule physicochemical format | Scientific Literature | ||
| 13. | ALA4724814 | B | Inhibition of human ERG expressed in CHO cells at 10 uM incubated for 5 mins by patch-clamp assay relative to control | Homo sapiens | 21 | ALA4715912 | cell-based format | Scientific Literature | |
| 14. | ALA4724815 | A | Total clearance in rat at 0.1 mg/kg, iv by LC/MS/MS analysis | Rattus norvegicus | 4 | ALA4715912 | organism-based format | Scientific Literature | |
| 15. | ALA4724816 | A | Intrinsic clearance in rat liver microsomes at 1 uM measured after 15 to 30 mins in presence of NADPH generating system by LC/MS/MS analysis | Rattus norvegicus | 15 | ALA4715912 | microsome format | Scientific Literature | |
| 16. | ALA4724817 | A | Intrinsic clearance in human liver microsomes at 1 uM measured after 15 to 30 mins in presence of NADPH generating system by LC/MS/MS analysis | Homo sapiens | 15 | ALA4715912 | microsome format | Scientific Literature | |
| 17. | ALA4724818 | B | Agonist activity at human GPR119 expressed in CHO cells co-expressing cyclic AMP response element incubated for 2 hrs by steady-glo luciferase assay | Homo sapiens | 21 | ALA4715912 | cell-based format | Scientific Literature | |
| 18. | ALA4812956 | F | Agonist activity at human GPR119 expressed in CHO cells co-expressing cyclic AMP response element-luciferase reporter gene incubated for 2 hrs by steady-glo luciferase assay | Homo sapiens | 21 | ALA4811273 | cell-based format | Scientific Literature | |
| 19. | ALA4812957 | B | Inhibition of human ERG expressed in CHO cells at 10 uM at holding potential of -80 mV by patch clamp method | Homo sapiens | 10 | ALA4811273 | cell-based format | Scientific Literature | |
| 20. | ALA4812972 | A | Intrinsic clearance in human liver microsomes | Homo sapiens | 2 | ALA4811273 | microsome format | Scientific Literature |
The page will load shortly, Thanks for your patience!