| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4775584 | B | Inhibition of Sialyltransferase in human MDA-MB-231 cells assessed as decrease p-talin-1 association with integrins beta1 and beta 3 after 48 hrs by immunofluorescence and coimmunoprecipitation assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 2. | ALA4775585 | B | Inhibition of rat alpha-2,3-N-ST3GALIII assessed as reduction in sialylated-product formation using Gal-beta1-4Glc and CMP-NeuSAc incubated for 1.5 hrs by reverse-phase HPLC analysis | Rattus norvegicus | 19 | single protein format | Scientific Literature | ||
| 3. | ALA4775586 | B | Inhibition of human alpha-2,6-ST6GAL1 assessed as reduction in sialylated-product formation using Gal-beta1-4GlcNac and CMP-NeuSAc incubated for 15 mins by reverse-phase HPLC analysis | Homo sapiens | 17 | single protein format | Scientific Literature | ||
| 4. | ALA4775588 | B | Inhibition of rat alpha-2,3-O-ST3GALI assessed as reduction in sialylated-product formation at 500 uM using p-nitrophenyl T-antigen and CMP-NeuSAc incubated for 15 mins by reverse-phase HPLC analysis relative to control | Rattus norvegicus | 17 | single protein format | Scientific Literature | ||
| 5. | ALA4775589 | B | Inhibition of rat alpha-2,3-O-ST3GALI assessed as reduction in sialylated-product formation at 1 mM using p-nitrophenyl T-antigen and CMP-NeuSAc incubated for 15 mins by reverse-phase HPLC analysis relative to control | Rattus norvegicus | 5 | single protein format | Scientific Literature | ||
| 6. | ALA4775591 | B | Selectivity ratio of inhibition of rat alpha-2,3-O-ST3GALI at 500 uM to IC50 for inhibition of rat alpha-2,3-N-ST3GALIII | Rattus norvegicus | 5 | assay format | Scientific Literature | ||
| 7. | ALA4775592 | B | Selectivity ratio of inhibition of rat alpha-2,3-O-ST3GALI at 1000 uM to IC50 for inhibition of rat alpha-2,3-N-ST3GALIII | Rattus norvegicus | 3 | assay format | Scientific Literature | ||
| 8. | ALA4775594 | B | Selectivity ratio of IC50 for of inhibition of rat alpha-2,3-O-ST3GALI to IC50 for inhibition of human alpha-2,6-ST6GAL1 | 17 | assay format | Scientific Literature | |||
| 9. | ALA4775595 | T | Toxicity in human MDA-MB-231 cells assessed as cell survival at >60 uM relative to control | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
| 10. | ALA4775596 | F | Inhibition of serum-induced cell migration of human MDA-MB-231 cells incubated for 16 hrs by Boyden chamber assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 11. | ALA4775597 | F | Inhibition of serum-induced cell migration of human MDA-MB-231 cells at 20 uM incubated for 16 hrs by Boyden chamber assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 12. | ALA4775598 | B | Inhibition of Sialyltransferase in human MDA-MB-231 cells assessed as suppression of sialylation of integrin subunit beta1/beta3/beta4/beta5 at 10 to 20 um after 48 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 13. | ALA4775599 | F | Antitumor activity against luciferase-tagged human MDA-MB-231 cells xenografted in BALB/c mouse assessed as induction of tumor suppression at 10 mg/kg/3 days, ip measured after 8 weeks | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA4775600 | F | Antitumor activity against luciferase-tagged human MDA-MB-231 cells xenografted in BALB/c mouse assessed as induction of delayed lung metastasis at 10 mg/kg/3 days, ip measured after 8 weeks | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA4775603 | F | Antitumor activity against luciferase-tagged human MDA-MB-231 cells xenografted in BALB/c mouse assessed as reduction in number of metastatic foci in lungs at 10 mg/kg/3 days, ip measured after 8 weeks by histological analysis | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA4775605 | F | Antitumor activity against luciferase-tagged human MDA-MB-231 cells xenografted in BALB/c mouse assessed as reduction in metastatic nodules in lymph node at 10 mg/kg/3 days, ip measured after 8 weeks by H and E staining based histological analysis | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA4775607 | T | Toxicity in BALB/c mouse xenografted with luciferase-tagged human MDA-MB-231 cells at 10 mg/kg/3 days, ip measured after 8 weeks by blood tests | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA4775608 | T | Toxicity in BALB/c mouse xenografted with luciferase-tagged human MDA-MB-231 cells assessed as effect on body weight at 10 mg/kg/3 days, ip measured after 8 weeks | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA4775611 | F | Antiangiogenesis activity against luciferase-tagged human MDA-MB-231 cells xenografted in BALB/c mouse assessed as reduction in number of vessels surrounding tumor nodules by measuring CD31 expression at 10 mg/kg/3 days, ip measured after 8 weeks by immunostaining | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA4775614 | F | Antiangiogenesis activity against luciferase-tagged human MDA-MB-231 cells xenografted in BALB/c mouse assessed as reduction in cell proliferation by measuring Ki67 expression at 10 mg/kg/3 days, ip measured after 8 weeks by immunostaining | Homo sapiens | 1 | organism-based format | Scientific Literature |
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