# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4718820 | B | Inhibition of human EGFR using poly[Glu:Tyr] (4:1) as substrate in presence of [gamma33P]ATP by radiometric HotSpot assay | Homo sapiens | 46 | ALA4715760 | single protein format | Scientific Literature | |
2. | ALA4718821 | A | Apparent permeability from apical to basolateral side in human Caco2 cells at 10 uM measured for 120 mins by LC-MS/MS analysis | Homo sapiens | 29 | ALA4715760 | cell-based format | Scientific Literature | |
3. | ALA4718822 | A | Efflux ratio of apparent permeability across basolateral to apical side over apical to basolateral side in human Caco2 cells at 10 uM measured for 120 mins by LC-MS/MS analysis | Homo sapiens | 29 | ALA4715760 | cell-based format | Scientific Literature | |
4. | ALA4718823 | A | Metabolic stability in pooled human liver microsomes assessed as half life at 3 uM measured up to 45 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 30 | ALA4715760 | microsome format | Scientific Literature | |
5. | ALA4718824 | A | Protein binding in plasma (unknown origin) assessed as unbound fraction at 5 uM by LC-MS/MS based equilibrium dialysis analysis | Not specified | 11 | ALA4715760 | cell-free format | Scientific Literature | |
6. | ALA4718825 | P | Aqueous solubility of compound in phosphate buffered saline at pH 7.4 incubated for 2 hrs by turbidimetric analysis | 29 | ALA4715760 | small-molecule physicochemical format | Scientific Literature | ||
7. | ALA4718826 | A | Inhibition of human ERG expressed in CHO cells at -80 mV holding potential by IonWorks patch-clamp electrophysiology assay | Homo sapiens | 11 | ALA4715760 | cell-based format | Scientific Literature | |
8. | ALA4718827 | F | Antiproliferative activity against mouse Ba/F3 cells expressing EGFR-L858R mutant assessed as inhibition of cell growth incubated for 48 hrs by XTT assay | Mus musculus | 11 | ALA4715760 | cell-based format | Scientific Literature | |
9. | ALA4718828 | F | Antiproliferative activity against human A431 cells | Homo sapiens | 10 | ALA4715760 | cell-based format | Scientific Literature | |
10. | ALA4718830 | F | Antiproliferative activity against human PC9 cells measured for 96 hrs by sytox green dye staining based proliferation assay | Homo sapiens | 2 | ALA4715760 | cell-based format | Scientific Literature | |
11. | ALA4718831 | F | Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by Cell Titer Glo luminescent cell viability assay | Homo sapiens | 2 | ALA4715760 | cell-based format | Scientific Literature | |
12. | ALA4718832 | F | Antiproliferative activity against human AU565 cells incubated for 72 hrs by ATPlite luminescence assay | Homo sapiens | 2 | ALA4715760 | cell-based format | Scientific Literature | |
13. | ALA4718833 | F | Antiproliferative activity against human C-33A cells incubated for 72 hrs by ATPlite luminescence assay | Homo sapiens | 2 | ALA4715760 | cell-based format | Scientific Literature | |
14. | ALA4718834 | F | Antiproliferative activity against human CAL27 cells | Homo sapiens | 2 | ALA4715760 | cell-based format | Scientific Literature | |
15. | ALA4718835 | F | Antiproliferative activity against human FaDU cells assessed as inhibition of cell growth incubated for 72 hrs by Cell Titer Glo luminescent cell viability assay | Homo sapiens | 2 | ALA4715760 | cell-based format | Scientific Literature | |
16. | ALA4718836 | F | Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 72 hrs by Cell Titer Glo luminescent cell viability assay | Homo sapiens | 2 | ALA4715760 | cell-based format | Scientific Literature | |
17. | ALA4718837 | F | Antiproliferative activity against human BXPC-3 cells measured for 96 hrs by sytox green dye staining based proliferation assay | Homo sapiens | 2 | ALA4715760 | cell-based format | Scientific Literature | |
18. | ALA4718839 | B | Inhibition of EGFR (unknown origin) at 100 nM using Tyr 04 peptide as substrate incubated for 1 hr by Z'-LYTE assay relative to control | Homo sapiens | 4 | ALA4715760 | single protein format | Scientific Literature | |
19. | ALA4718840 | B | Inhibition of EGFR (unknown origin) using Tyr 04 peptide as substrate incubated for 1 hr by Z'-LYTE assay | Homo sapiens | 4 | ALA4715760 | single protein format | Scientific Literature | |
20. | ALA4718841 | A | Apparent permeability from basolateral to apical side in human Caco2 cells at 10 uM measured for 120 mins by LC-MS/MS analysis | Homo sapiens | 29 | ALA4715760 | cell-based format | Scientific Literature |