| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4711940 | F | Neuroprotective activity in HdhQ140 knock-in mouse model assessed as decrease in staining intensity of microglia in striatum at 5 mg/kg, iv QD for 4 weeks by Iba1 staining based immunostaining analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 2. | ALA4711941 | F | Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis | Homo sapiens | 29 | cell-based format | Scientific Literature | ||
| 3. | ALA4711942 | B | Antagonist activity at GPR52 in mouse STHdhQ7/111 cells assessed as decrease in mHTT levels incubated for 48 hrs in presence of 2B7-terbium and 2166-D2 antibodies by TR-FRET | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA4711943 | B | Antagonist activity at GPR52 in mouse STHdhQ7/111 cells assessed as decrease in mHTT levels at 1 to 10 uM incubated for 48 hrs in presence of 2B7-terbium and 2166-D2 antibodies by western blot analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA4711944 | B | Antagonist activity at GPR52 in mouse STHdhQ7/111 cells assessed as decrease in wild type HTT levels at 1 to 10 uM incubated for 48 hrs in presence of 2B7-terbium and 2166-D2 antibodies by western blot analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA4711945 | F | Decrease in mHTT level in GPR52 knockdown mouse STHdhQ7/111 cells with at 1 to 10 uM incubated for 48 hrs in presence of 2B7-terbium and 2166-D2 antibodies by TR-FRET analysis | Mus musculus | 1 | tissue-based format | Scientific Literature | ||
| 7. | ALA4711946 | F | Decrease in wild type HTT level in GPR52 knockdown mouse STHdhQ7/111 cells with at 1 to 10 uM incubated for 48 hrs in presence of 2B7-terbium and 2166-D2 antibodies by TR-FRET analysis | Mus musculus | 1 | tissue-based format | Scientific Literature | ||
| 8. | ALA4711947 | B | Antagonist activity at GPR52 in neurons from HdhQ7/Q140 mouse assessed as decrease in mHTT levels at 0.1 to 3 uM incubated for 48 hrs in presence of 2B7-terbium and 2166-D2 antibodies by TR-FRET analysis | Mus musculus | 1 | tissue-based format | Scientific Literature | ||
| 9. | ALA4711948 | B | Antagonist activity at GPR52 in neurons from HdhQ7/Q140 mouse assessed as decrease in wild type HTT levels at 0.1 to 3 uM incubated for 48 hrs in presence of 2B7-terbium and 2166-D2 antibodies by TR-FRET analysis | Mus musculus | 1 | tissue-based format | Scientific Literature | ||
| 10. | ALA4711949 | B | Antagonist activity at GPR52 in neurons from HdhQ7/Q140 mouse assessed as decrease in mHTT levels at 0.3 to 3 uM incubated for 48 hrs in presence of 2B7-terbium and 2166-D2 antibodies by western blot analysis | Mus musculus | 1 | tissue-based format | Scientific Literature | ||
| 11. | ALA4711950 | B | Antagonist activity at GPR52 in neurons from HdhQ7/Q140 mouse assessed as decrease in wild type HTT levels at 0.3 to 3 uM incubated for 48 hrs in presence of 2B7-terbium and 2166-D2 antibodies by western blot analysis | Mus musculus | 1 | tissue-based format | Scientific Literature | ||
| 12. | ALA4711951 | F | Neuroprotective activity in neurons from HdhQ7/Q140 mouse assessed as rescue from mHTT-induced neuronal loss at 3 uM incubated for 48 hrs maintained in absence of growth factor N2 and B27 under starvation condition by immunostaining based analysis | Mus musculus | 1 | tissue-based format | Scientific Literature | ||
| 13. | ALA4711952 | F | Neuroprotective activity in neurons from HdhQ7/Q140 mouse assessed as rescue from mHTT-induced neuronal loss by measuring reduction in caspase 3 activity at 3 uM incubated for 48 hrs maintained in absence of growth factor N2 and B27 under starvation condition by green fluorescent dye based assay | Mus musculus | 1 | tissue-based format | Scientific Literature | ||
| 14. | ALA4711953 | F | Invivo antagonist activity at GPR52 in HdhQ140 knock-in mouse model assessed as reduction in mHTT levels in striatum at 0.5 mM, icv QD for 3 weeks by TR-FRET analysis | Mus musculus | 1 | assay format | Scientific Literature | ||
| 15. | ALA4711954 | F | Invivo antagonist activity at GPR52 in HdhQ140 knock-in mouse model assessed as reduction in mHTT levels in cortex at 0.5 mM, icv QD for 3 weeks by TR-FRET analysis | Mus musculus | 1 | assay format | Scientific Literature | ||
| 16. | ALA4711955 | F | Invivo antagonist activity at GPR52 in wild type mouse model assessed as reduction in wild type HTT levels at 0.5 mM, icv QD for 3 weeks by TR-FRET analysis | Mus musculus | 1 | assay format | Scientific Literature | ||
| 17. | ALA4711956 | F | Invivo antagonist activity at GPR52 in HdhQ140 knock-in mouse model assessed as reduction in mHTT aggregate levels in striatum at 0.5 mM, icv QD for 3 weeks by S380 antibody based immunostaining based analysis | Mus musculus | 1 | assay format | Scientific Literature | ||
| 18. | ALA4711957 | F | Neuroprotective activity in HdhQ140 knock-in mouse model assessed as decrease in staining intensity of microglia in striatum at 0.5 mM, icv QD for 3 weeks by Iba1staining based immunostaining analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA4711958 | A | Drug uptake in wild type mouse brain at 5 mg/kg, iv measured 0.5 to 6 hrs | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA4711959 | F | Neuroprotective activity in HdhQ140 mouse model assessed as latency to fall at 5 mg/kg, iv QD for 4 weeks by rotarod test | Mus musculus | 1 | organism-based format | Scientific Literature |
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