#	Aladdin ID	Assay Type	Description	Organism	Compounds	Reference	BAO Format	Source
1.	ALA4711940	F	Neuroprotective activity in HdhQ140 knock-in mouse model assessed as decrease in staining intensity of microglia in striatum at 5 mg/kg, iv QD for 4 weeks by Iba1 staining based immunostaining analysis	Mus musculus	1	ALA4706623	organism-based format	Scientific Literature
2.	ALA4711941	F	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	Homo sapiens	29	ALA4706623	cell-based format	Scientific Literature
3.	ALA4711942	B	Antagonist activity at GPR52 in mouse STHdhQ7/111 cells assessed as decrease in mHTT levels incubated for 48 hrs in presence of 2B7-terbium and 2166-D2 antibodies by TR-FRET	Mus musculus	1	ALA4706623	cell-based format	Scientific Literature
4.	ALA4711943	B	Antagonist activity at GPR52 in mouse STHdhQ7/111 cells assessed as decrease in mHTT levels at 1 to 10 uM incubated for 48 hrs in presence of 2B7-terbium and 2166-D2 antibodies by western blot analysis	Mus musculus	1	ALA4706623	cell-based format	Scientific Literature
5.	ALA4711944	B	Antagonist activity at GPR52 in mouse STHdhQ7/111 cells assessed as decrease in wild type HTT levels at 1 to 10 uM incubated for 48 hrs in presence of 2B7-terbium and 2166-D2 antibodies by western blot analysis	Mus musculus	1	ALA4706623	cell-based format	Scientific Literature
6.	ALA4711945	F	Decrease in mHTT level in GPR52 knockdown mouse STHdhQ7/111 cells with at 1 to 10 uM incubated for 48 hrs in presence of 2B7-terbium and 2166-D2 antibodies by TR-FRET analysis	Mus musculus	1	ALA4706623	tissue-based format	Scientific Literature
7.	ALA4711946	F	Decrease in wild type HTT level in GPR52 knockdown mouse STHdhQ7/111 cells with at 1 to 10 uM incubated for 48 hrs in presence of 2B7-terbium and 2166-D2 antibodies by TR-FRET analysis	Mus musculus	1	ALA4706623	tissue-based format	Scientific Literature
8.	ALA4711947	B	Antagonist activity at GPR52 in neurons from HdhQ7/Q140 mouse assessed as decrease in mHTT levels at 0.1 to 3 uM incubated for 48 hrs in presence of 2B7-terbium and 2166-D2 antibodies by TR-FRET analysis	Mus musculus	1	ALA4706623	tissue-based format	Scientific Literature
9.	ALA4711948	B	Antagonist activity at GPR52 in neurons from HdhQ7/Q140 mouse assessed as decrease in wild type HTT levels at 0.1 to 3 uM incubated for 48 hrs in presence of 2B7-terbium and 2166-D2 antibodies by TR-FRET analysis	Mus musculus	1	ALA4706623	tissue-based format	Scientific Literature
10.	ALA4711949	B	Antagonist activity at GPR52 in neurons from HdhQ7/Q140 mouse assessed as decrease in mHTT levels at 0.3 to 3 uM incubated for 48 hrs in presence of 2B7-terbium and 2166-D2 antibodies by western blot analysis	Mus musculus	1	ALA4706623	tissue-based format	Scientific Literature
11.	ALA4711950	B	Antagonist activity at GPR52 in neurons from HdhQ7/Q140 mouse assessed as decrease in wild type HTT levels at 0.3 to 3 uM incubated for 48 hrs in presence of 2B7-terbium and 2166-D2 antibodies by western blot analysis	Mus musculus	1	ALA4706623	tissue-based format	Scientific Literature
12.	ALA4711951	F	Neuroprotective activity in neurons from HdhQ7/Q140 mouse assessed as rescue from mHTT-induced neuronal loss at 3 uM incubated for 48 hrs maintained in absence of growth factor N2 and B27 under starvation condition by immunostaining based analysis	Mus musculus	1	ALA4706623	tissue-based format	Scientific Literature
13.	ALA4711952	F	Neuroprotective activity in neurons from HdhQ7/Q140 mouse assessed as rescue from mHTT-induced neuronal loss by measuring reduction in caspase 3 activity at 3 uM incubated for 48 hrs maintained in absence of growth factor N2 and B27 under starvation condition by green fluorescent dye based assay	Mus musculus	1	ALA4706623	tissue-based format	Scientific Literature
14.	ALA4711953	F	Invivo antagonist activity at GPR52 in HdhQ140 knock-in mouse model assessed as reduction in mHTT levels in striatum at 0.5 mM, icv QD for 3 weeks by TR-FRET analysis	Mus musculus	1	ALA4706623	assay format	Scientific Literature
15.	ALA4711954	F	Invivo antagonist activity at GPR52 in HdhQ140 knock-in mouse model assessed as reduction in mHTT levels in cortex at 0.5 mM, icv QD for 3 weeks by TR-FRET analysis	Mus musculus	1	ALA4706623	assay format	Scientific Literature
16.	ALA4711955	F	Invivo antagonist activity at GPR52 in wild type mouse model assessed as reduction in wild type HTT levels at 0.5 mM, icv QD for 3 weeks by TR-FRET analysis	Mus musculus	1	ALA4706623	assay format	Scientific Literature
17.	ALA4711956	F	Invivo antagonist activity at GPR52 in HdhQ140 knock-in mouse model assessed as reduction in mHTT aggregate levels in striatum at 0.5 mM, icv QD for 3 weeks by S380 antibody based immunostaining based analysis	Mus musculus	1	ALA4706623	assay format	Scientific Literature
18.	ALA4711957	F	Neuroprotective activity in HdhQ140 knock-in mouse model assessed as decrease in staining intensity of microglia in striatum at 0.5 mM, icv QD for 3 weeks by Iba1staining based immunostaining analysis	Mus musculus	1	ALA4706623	organism-based format	Scientific Literature
19.	ALA4711958	A	Drug uptake in wild type mouse brain at 5 mg/kg, iv measured 0.5 to 6 hrs	Mus musculus	1	ALA4706623	organism-based format	Scientific Literature
20.	ALA4711959	F	Neuroprotective activity in HdhQ140 mouse model assessed as latency to fall at 5 mg/kg, iv QD for 4 weeks by rotarod test	Mus musculus	1	ALA4706623	organism-based format	Scientific Literature