| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4773575 | B | Inhibition of recombinant human His-tagged HDAC6 expressed in baculovirus infected insect cells using Ac-Leu-Gly-Lys(Ac)-AMC as substrate measured after 30 mins by fluorescence assay | Homo sapiens | 37 | cell-based format | Scientific Literature | ||
| 2. | ALA4773576 | F | Antiproliferative activity against human MDA-MB-231 cells measured after 24 hrs by MTT assay | Homo sapiens | 37 | cell-based format | Scientific Literature | ||
| 3. | ALA4773577 | B | Inhibition of recombinant human His-tagged HDAC1 expressed in insect cells using Ac-Leu-Gly-Lys(Ac)-AMC as substrate measured after 30 mins by fluorescence assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 4. | ALA4773578 | B | Inhibition of human full-length C-terminal FLAG-tagged HDAC2 expressed in baculovirus infected Sf9 insect cells using Ac-Leu-Gly-Lys(Ac)-AMC as substrate measured after 30 mins by fluorescence assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 5. | ALA4773579 | B | Inhibition of recombinant human GST-fused HDAC3/NCOR1 (397 to 503 residues) expressed in baculovirus infected insect cells using Ac-Leu-Gly-Lys(Ac)-AMC as substrate measured after 30 mins by fluorescence assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 6. | ALA4773580 | B | Inhibition of recombinant human full-length C-terminal His-tagged HDAC8 expressed in baculovirus infected Sf9 insect cells using Ac-Leu-Gly-Lys(Tfa)-AMC as substrate measured after 30 mins by fluorescence assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 7. | ALA4773581 | B | Inhibition of recombinant human N-terminal GST-tagged HDAC4 (627 to end residues) expressed in baculovirus infected Sf9 insect cells using AcLeu-Gly-Lys(Tfa)-AMC as substrate measured after 30 mins by fluorescence assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 8. | ALA4773582 | B | Inhibition of recombinant human full-length N-terminal GST-tagged HDAC5 expressed in baculovirus infected Sf9 insect cells using AcLeu-Gly-Lys(Tfa)-AMC as substrate measured after 30 mins by fluorescence assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 9. | ALA4773583 | B | Inhibition of HDAC7 (unknown origin) using AcLeu-Gly-Lys(Tfa)-AMC as substrate measured after 30 mins by fluorescence assay | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 10. | ALA4773584 | B | Inhibition of recombinant human full-length N-terminal GST-tagged HDAC9 (1 to 1069 residues) expressed in wheat germ expression system using Ac-Leu-Gly-Lys(Tfa)-AMC as substrate measured after 30 mins by fluorescence assay | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 11. | ALA4773585 | B | Inhibition of recombinant human C-terminal His-tagged HDAC10 expressed in baculovirus infected Sf9 insect cells using Ac-Arg-His-Lys(Ac)-Lys(Ac)-AMC as substrate measured after 30 mins by fluorescence assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 12. | ALA4773586 | B | Inhibition of recombinant human N-terminal His-tagged HDAC11 expressed in baculovirus infected Sf9 insect cells using Ac-Arg-His-Lys(Ac)-Lys(Ac)-AMC as substrate measured after 30 mins by fluorescence assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 13. | ALA4773587 | F | Antiproliferative activity against human MDA-MB-231 cells measured after 48 hrs by MTT assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 14. | ALA4773588 | F | Antiproliferative activity against human MDA-MB-231 cells measured after 72 hrs by MTT assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 15. | ALA4773589 | F | Antiproliferative activity against human MDA-MB-231 cells measured after 96 hrs by MTT assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 16. | ALA4773590 | B | Inhibition of HDAC6 in human MDA-MB-231 cells assessed as increase in alpha-tubulin acetylation at 2.5 to 10 uM measured after 24 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 17. | ALA4773591 | B | Inhibition of HDAC6 in human MDA-MB-231 cells assessed as increase in HSP90 acetylation at 2.5 to 10 uM measured after 24 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 18. | ALA4773592 | F | Induction of apoptosis in human MDA-MB-231 cells assessed as increase in DNA fragmentation at 2.5 to 10 uM measured after 24 hrs by Hoechst 33258 staining based immunofluorescence assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 19. | ALA4773593 | F | Induction of apoptosis in human MDA-MB-231 cells measured after 24 hrs by Annexin-V/propidium iodide staining based flow cytometry | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 20. | ALA4773594 | F | Induction of apoptosis in human MDA-MB-231 cells assessed as viable cells at 2.5 uM measured after 24 hrs by Annexin-V/propidium iodide staining based flow cytometry (Rvb = 95.68 to 98.38%) | Homo sapiens | 2 | cell-based format | Scientific Literature |
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