Antitumor activity against human A-375 cells xenografted in Balb/c nude mouse assessed as change in tumor stroma at 75 mg/kg, ip administered 3 times a week during first week and twice a week for next 2 weeks measured post last dose by trichrome staining based histopathological analysis
Antitumor activity against human A-375 cells xenografted in Balb/c nude mouse assessed as reduction in tumor size at 75 mg/kg, ip administered 3 times a week during first week and twice a week for 2 week by caliper method relative to control
Toxicity in Balb/c nude mouse xenografted with human A-375 cells assessed as reduction in body weight at 75 mg/kg, ip administered 3 times a week during first week and twice a week for 2 week
Toxicity in Balb/c nude mouse xenografted with human A-375 cells assessed as morbidity at 75 mg/kg, ip administered 3 times a week during first week and twice a week for 2 week
Toxicity in Balb/c nude mouse xenografted with human A-375 cells assessed as mortality at 75 mg/kg, ip administered 3 times a week during first week and twice a week for 2 week
Toxicity in Balb/c nude mouse xenografted with human A-375 cells assessed as effect on liver pathology at 75 mg/kg, ip administered 3 times a week during first week and twice a week for 2 week measured post last dose by pathological analysis
Toxicity in Balb/c nude mouse xenografted with human A-375 cells assessed as effect on spleen pathology at 75 mg/kg, ip administered 3 times a week during first week and twice a week for 2 week measured post last dose by pathological analysis
Toxicity in Balb/c nude mouse xenografted with human A-375 cells assessed as effect on gut pathology at 75 mg/kg, ip administered 3 times a week during first week and twice a week for 2 week measured post last dose by pathological analysis
Toxicity in Balb/c nude mouse xenografted with human A-375 cells assessed as effect on pancreas pathology at 75 mg/kg, ip administered 3 times a week during first week and twice a week for 2 week measured post last dose by pathological analysis
Antitumor activity against human A-375 cells xenografted in Balb/c nude mouse assessed as reduction in tumor size at 30 mg/kg, ip administered 5 times a week for 3 weeks by caliper method
Toxicity in Balb/c nude mouse xenografted with human A-375 cells assessed as change in body weight at 30 mg/kg, ip administered 5 times a week for 3 weeks
Toxicity in Balb/c nude mouse xenografted with human A-375 cells assessed as pathological changes at 30 mg/kg, ip administered 5 times a week for 3 weeks measured post last dose by histopathological analysis
Antitumor activity against human A-375 cells xenografted in Balb/c nude mouse assessed as reduction in tumor size at 25 mg/kg, ip administered 3 times a week for 3 weeks by caliper method relative to control