| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4669200 | B | Potency index, ratio of (R)-MB001 EC50 to test compound EC50 for inhibition of RPE65 in bovine RPE microsomes assessed as reduction in 11-cis-retinol production using all-trans-retinol as substrate pre-incubated with enzyme for 5 mins followed by further incubation with all-trans-retinol for 1 hr by normal phase HPLC analysis | Bos taurus | 2 | microsome format | Scientific Literature | ||
| 2. | ALA4669201 | B | Inhibition of RPE65 in bovine RPE microsomes assessed as reduction in 11-cis-retinol production using all-trans-retinol as substrate pre-incubated with enzyme for 5 mins followed by further incubation with all-trans-retinol for 1 hr by normal phase HPLC analysis | Bos taurus | 3 | microsome format | Scientific Literature | ||
| 3. | ALA5032820 | B | Inhibition of RPE65 in bovine retinal pigment epithelium microsomes assessed as decrease of 11-cis-retinol using trans-retinol measured after 1 hr by normal phase HPLC analysis | Bos taurus | 18 | microsome format | Scientific Literature | ||
| 4. | ALA5032821 | A | Drug distribution in wild type BL/6J mouse eyes measured at 380 nM, IP administered single dose per eye after 3 hrs by LC-MS/MS electrospray ionization fragmentation spectra method | Mus musculus | 4 | tissue-based format | Scientific Literature | ||
| 5. | ALA5032822 | A | Drug distribution in wild type BL/6J mouse eyes measured at 380 nM, IP administered single dose per eye after 24 hrs by LC-MS/MS electrospray ionization fragmentation spectra method | Mus musculus | 1 | tissue-based format | Scientific Literature |
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