| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4767044 | B | Inhibition of HYSGRGK(Ac)GGK(Ac)GLGK(Ac)GGAK(Ac)RHRK(Biotin)-OH binding to recombinant human His6-tagged BRD4 bromodomain 1 (N44 to E168 residues) expressed in Escherichia coli BL21 (DE3) cells measured after 2 hrs by Alphascreen assay | Homo sapiens | 50 | ALA4765238 | cell-based format | Scientific Literature | |
| 2. | ALA4767045 | B | Binding affinity to human recombinant His6-tagged BRD4 bromodomain 1 (N44 to E168 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as dissociation constant incubated for 1 hr by isothermal titration calorimetry | Homo sapiens | 4 | ALA4765238 | cell-based format | Scientific Literature | |
| 3. | ALA4767046 | B | Binding affinity to human recombinant His6-tagged BRD4 bromodomain 1 (N44 to E168 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as change in melting temperature at 200 uM incubated for 30 mins by SYPRO orange dye based thermal shift assay | Homo sapiens | 49 | ALA4765238 | cell-based format | Scientific Literature | |
| 4. | ALA4767047 | B | Binding affinity to human recombinant His6-tagged BRD4 bromodomain 1 (N44 to E168 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as change in entropy incubated for 1 hr by isothermal titration calorimetry | Homo sapiens | 4 | ALA4765238 | cell-based format | Scientific Literature | |
| 5. | ALA4767048 | B | Binding affinity to human recombinant His6-tagged BRD4 bromodomain 1 (N44 to E168 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as change in enthalpy incubated for 1 hr by isothermal titration calorimetry | Homo sapiens | 4 | ALA4765238 | cell-based format | Scientific Literature | |
| 6. | ALA4767049 | B | Binding affinity to human recombinant His6-tagged BRD4 bromodomain 1 (N44 to E168 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as gibbs free energy change incubated for 1 hr by isothermal titration calorimetry | Homo sapiens | 4 | ALA4765238 | cell-based format | Scientific Literature | |
| 7. | ALA4767050 | B | Binding affinity to human recombinant His6-tagged BRD2 bromodomain 1 (K77 to N194 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as change in melting temperature at 200 uM incubated for 30 mins by SYPRO orange dye based thermal shift assay | Homo sapiens | 4 | ALA4765238 | cell-based format | Scientific Literature | |
| 8. | ALA4767051 | B | Binding affinity to human recombinant His6-tagged BRD3 bromodomain 1 (P24 to E144 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as change in melting temperature at 200 uM incubated for 30 mins by SYPRO orange dye based thermal shift assay | Homo sapiens | 4 | ALA4765238 | cell-based format | Scientific Literature | |
| 9. | ALA4767052 | B | Binding affinity to human recombinant His6-tagged BRDT bromodomain 1 (N21 to E137 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as change in melting temperature at 200 uM incubated for 30 mins by SYPRO orange dye based thermal shift assay | Homo sapiens | 4 | ALA4765238 | cell-based format | Scientific Literature | |
| 10. | ALA4767053 | B | Binding affinity to human recombinant His6-tagged BAZ2B (S1858 to S1972 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as change in melting temperature at 200 uM incubated for 30 mins by SYPRO orange dye based thermal shift assay | Homo sapiens | 4 | ALA4765238 | cell-based format | Scientific Literature | |
| 11. | ALA4767054 | B | Binding affinity to human recombinant His6-tagged BRD1 (E556 to A688 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as change in melting temperature at 200 uM incubated for 30 mins by SYPRO orange dye based thermal shift assay | Homo sapiens | 4 | ALA4765238 | cell-based format | Scientific Literature | |
| 12. | ALA4767055 | B | Binding affinity to human recombinant His6-tagged BRD9 (L14 to Q134 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as change in melting temperature at 200 uM incubated for 30 mins by SYPRO orange dye based thermal shift assay | Homo sapiens | 4 | ALA4765238 | cell-based format | Scientific Literature | |
| 13. | ALA4767056 | B | Binding affinity to human recombinant His6-tagged PCAF (G715 to D831 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as change in melting temperature at 200 uM incubated for 30 mins by SYPRO orange dye based thermal shift assay | Homo sapiens | 4 | ALA4765238 | cell-based format | Scientific Literature | |
| 14. | ALA4767057 | B | Binding affinity to human recombinant His6-tagged TAF1 bromodomain 1 (R1377 to D1503 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as change in melting temperature at 200 uM incubated for 30 mins by SYPRO orange dye based thermal shift assay | Homo sapiens | 4 | ALA4765238 | cell-based format | Scientific Literature | |
| 15. | ALA4767058 | B | Binding affinity to human recombinant His6-tagged ASH1L (E2433 to E2564 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as change in melting temperature at 200 uM incubated for 30 mins by SYPRO orange dye based thermal shift assay | Homo sapiens | 4 | ALA4765238 | cell-based format | Scientific Literature | |
| 16. | ALA4767059 | B | Binding affinity to human recombinant His6-tagged EP300 (A1040 to G1161 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as change in melting temperature at 200 uM incubated for 30 mins by SYPRO orange dye based thermal shift assay | Homo sapiens | 4 | ALA4765238 | cell-based format | Scientific Literature | |
| 17. | ALA4767060 | B | Binding affinity to human recombinant His6-tagged CREBBP (R1081 to G1197 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as change in melting temperature at 200 uM incubated for 30 mins by SYPRO orange dye based thermal shift assay | Homo sapiens | 4 | ALA4765238 | cell-based format | Scientific Literature | |
| 18. | ALA4767061 | F | Antiproliferative activity against AR-positive human LNCAP cells assessed as reduction in cell viability incubated for 96 hrs by cell-titer glo assay | Homo sapiens | 5 | ALA4765238 | cell-based format | Scientific Literature | |
| 19. | ALA4767062 | F | Antiproliferative activity against AR-positive human C4-2B cells assessed as reduction in cell viability incubated for 96 hrs by cell-titer glo assay | Homo sapiens | 5 | ALA4765238 | cell-based format | Scientific Literature | |
| 20. | ALA4767063 | F | Antiproliferative activity against AR-positive human 22Rv1 cells assessed as reduction in cell viability incubated for 96 hrs by cell-titer glo assay | Homo sapiens | 5 | ALA4765238 | cell-based format | Scientific Literature |
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