# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4769103 | Binding | Inhibition of recombinant human His6-tagged AMPK alpha1 using ULight CRBtide as substrate incubated for 1 hr followed by substrate addition and measured after 1 hr by TR-FRET assay | Homo sapiens | 21 | ALA4765298 | single protein format | Scientific Literature | |
2. | ALA4769105 | Binding | Inhibition of recombinant human His6-tagged AMPK alpha2 using ULight CRBtide as substrate incubated for 1 hr followed by substrate addition and measured after 1 hr by TR-FRET assay | Homo sapiens | 20 | ALA4765298 | single protein format | Scientific Literature | |
3. | ALA4769107 | Binding | Inhibition of tracer 236 binding to recombinant human N-terminal GST-tagged full length KDR (790 to 1356 residues) expressed in baculovirus expression system incubated for 1 hr by Lanthascreen assay | Homo sapiens | 12 | ALA4765298 | assay format | Scientific Literature | |
4. | ALA4769109 | Binding | Inhibition of AMPK in human K562 cells assessed as p-ACC (Ser79) level at 5 uM in glucose free medium and in presence of 2-Deoxy-D-glucose measured after 3 hrs by ELISA relative to control | Homo sapiens | 4 | ALA4765298 | cell-based format | Scientific Literature | |
5. | ALA4769111 | Binding | Inhibition of AMPK in human K562 cells assessed as p-ACC (Ser79) level at 3.125 to 12.5 uM in glucose free medium and in presence of 2-Deoxy-D-glucose measured after 3 hrs by ELISA | Homo sapiens | 1 | ALA4765298 | cell-based format | Scientific Literature | |
6. | ALA4769114 | ADME | Cytotoxicity against human K562 cells assessed as reduction in cell viability at 50 uM incubated for 72 hrs by MTS assay relative to control | Homo sapiens | 4 | ALA4765298 | cell-based format | Scientific Literature | |
7. | ALA4769116 | ADME | Cytotoxicity against human K562 cells assessed as reduction in cell viability at 50 uM incubated for 24 hrs by cell-titer glo assay relative to control | Homo sapiens | 5 | ALA4765298 | cell-based format | Scientific Literature | |
8. | ALA4769118 | ADME | Cytotoxicity against human K562 cells assessed as reduction in cell viability at 50 uM incubated for 24 hrs by celltox-green assay relative to control | Homo sapiens | 10 | ALA4765298 | cell-based format | Scientific Literature | |
9. | ALA4769119 | Binding | Inhibition of wild-type human partial length AMPK alpha1 (M1 to E306 residues) expressed in bacterial expression system at 100 nM by Kinomescan method relative to control | Homo sapiens | 3 | ALA4765298 | assay format | Scientific Literature | |
10. | ALA4769120 | Binding | Inhibition of wild-type human partial length AMPK alpha2 (M1 to E306 residues) expressed in bacterial expression system at 100 nM by Kinomescan method relative to control | Homo sapiens | 3 | ALA4765298 | assay format | Scientific Literature | |
11. | ALA4769121 | Binding | Inhibition of wild-type human partial length VEGFR2 (R787 to P1253 residues) expressed in mammalian expression system at 100 nM by Kinomescan method relative to control | Homo sapiens | 3 | ALA4765298 | assay format | Scientific Literature | |
12. | ALA4769122 | Binding | Inhibition of wild-type human full length BTK (M1 to S659 residues) expressed in mammalian expression system at 100 nM by Kinomescan method relative to control | Homo sapiens | 3 | ALA4765298 | assay format | Scientific Literature | |
13. | ALA4769123 | Binding | Inhibition of wild-type human partial length CSF1R (I564 to S939 residues) expressed in bacterial expression system at 100 nM by Kinomescan method relative to control | Homo sapiens | 3 | ALA4765298 | assay format | Scientific Literature | |
14. | ALA4769124 | Binding | Inhibition of wild-type human partial length autoinhibited CSF1R (Y538 to S939 residues) expressed in mammalian expression system at 100 nM by Kinomescan method relative to control | Homo sapiens | 3 | ALA4765298 | assay format | Scientific Literature | |
15. | ALA4769125 | Binding | Inhibition of wild-type human partial length FLT1 (R781 to F1239 residues) expressed in bacterial expression system at 100 nM by Kinomescan method relative to control | Homo sapiens | 3 | ALA4765298 | assay format | Scientific Literature | |
16. | ALA4769126 | Binding | Inhibition of wild-type human partial length JAK1 JH2 pseudokinase domain (R537 to D855 residues) expressed in mammalian expression system at 100 nM by Kinomescan method relative to control | Homo sapiens | 3 | ALA4765298 | assay format | Scientific Literature | |
17. | ALA4769127 | Binding | Inhibition of wild-type human partial length autoinhibited KIT (Y545 to D952 residues) expressed in mammalian expression system at 100 nM by Kinomescan method relative to control | Homo sapiens | 3 | ALA4765298 | assay format | Scientific Literature | |
18. | ALA4769128 | ADME | Cytotoxicity against human K562 cells assessed as reduction in cell viability incubated for 48 hrs by celltox-green assay | Homo sapiens | 11 | ALA4765298 | cell-based format | Scientific Literature |