# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4680970 | Functional | Antiplasmodial activity against Plasmodium berghei ookinete form assessed as growth inhibition incubated for 22 hrs by GFP-based fluorescence microscopic analysis | Plasmodium berghei | 4 | ALA4680079 | organism-based format | Scientific Literature | |
2. | ALA4680971 | Functional | Antiplasmodial activity against Plasmodium yoelli liver stage forms | Plasmodium yoelii | 4 | ALA4680079 | organism-based format | Scientific Literature | |
3. | ALA4680972 | Functional | Antiplasmodial activity against late stage (IV/V) Plasmodium falciparum NF54 gametocytes transfected with GFP-LUC assessed as growth inhibition incubated for 72 hrs by mitotracker Red-CMXROS dye based fluorescence microscopic analysis | Plasmodium falciparum | 7 | ALA4680079 | organism-based format | Scientific Literature | |
4. | ALA4680973 | Functional | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human red blood cells assessed as growth inhibition by SYBR Green fluorescence assay | Plasmodium falciparum | 42 | ALA4680079 | organism-based format | Scientific Literature | |
5. | ALA4680974 | ADME | Antiproliferative activity against human MRC5 cells assessed as reduction in cell viability after 68 hrs by resazurin dye based fluorescence assay | Homo sapiens | 31 | ALA4680079 | cell-based format | Scientific Literature | |
6. | ALA4680975 | ADME | Intrinsic clearance in CD1 mouse liver microsomes at 0.5 uM in presence of NADPH incubated upto 30 mins by UPLC-MS/MS analysis | Mus musculus | 23 | ALA4680079 | microsome format | Scientific Literature | |
7. | ALA4680976 | Physicochemical | Kinetic aqueous solubility of the compound by laser nephelometry | 21 | ALA4680079 | small-molecule physicochemical format | Scientific Literature | ||
8. | ALA4680977 | ADME | Permeability of the compound at 10 uM incubated for 5 hrs by UPLC-MS/MS analysis based PAMPA method | 17 | ALA4680079 | assay format | Scientific Literature | ||
9. | ALA4680979 | ADME | Intrinsic clearance in human liver microsomes at 0.5 uM in presence of NADPH incubated upto 30 mins by UPLC-MS/MS analysis | Homo sapiens | 6 | ALA4680079 | microsome format | Scientific Literature | |
10. | ALA4680980 | ADME | Protein binding in CD1 mouse plasma measured after 5 hr by UPLC-MS/MS analysis based equilibrium dialysis method | Mus musculus | 6 | ALA4680079 | cell-free format | Scientific Literature | |
11. | ALA4680981 | Binding | Inhibition of human ERG by IonWorks patch-clamp electrophysiology method | Homo sapiens | 5 | ALA4680079 | single protein format | Scientific Literature | |
12. | ALA4680983 | ADME | Clearance in NMRI mouse blood at 3 mg/kg, iv administered as bolus dose by UPLC-MS/MS analysis | Mus musculus | 3 | ALA4680079 | organism-based format | Scientific Literature | |
13. | ALA4680984 | ADME | Volume of distribution at steady state in NMRI mouse at 3 mg/kg, iv administered as bolus dose by UPLC-MS/MS analysis | Mus musculus | 3 | ALA4680079 | organism-based format | Scientific Literature | |
14. | ALA4680985 | ADME | Half-life in NMRI mouse at 3 mg/kg, iv administered as bolus dose by UPLC-MS/MS analysis | Mus musculus | 3 | ALA4680079 | organism-based format | Scientific Literature | |
15. | ALA4680986 | ADME | Cmax in NMRI mouse at 10 mg/kg, po administered as gavage by UPLC-MS/MS analysis | Mus musculus | 3 | ALA4680079 | organism-based format | Scientific Literature | |
16. | ALA4680987 | ADME | AUC in NMRI mouse at 10 mg/kg, po administered as gavage by UPLC-MS/MS analysis | Mus musculus | 3 | ALA4680079 | organism-based format | Scientific Literature | |
17. | ALA4680988 | ADME | Tmax in NMRI mouse at 10 mg/kg, po administered as gavage by UPLC-MS/MS analysis | Mus musculus | 3 | ALA4680079 | organism-based format | Scientific Literature | |
18. | ALA4680989 | ADME | Oral bioavailability in NMRI mouse at 10 mg/kg administered via gavage by UPLC-MS/MS analysis | Mus musculus | 4 | ALA4680079 | organism-based format | Scientific Literature | |
19. | ALA4680990 | Functional | Antiplasmodial activity against Plasmodium berghei ANKA infected in NMRI mouse assessed as reduction in parasitemia at 30 mg/kg, po QD for 4 days | Plasmodium berghei | 4 | ALA4680079 | organism-based format | Scientific Literature | |
20. | ALA4680991 | Functional | Antiplasmodial activity against Plasmodium berghei ANKA infected in NMRI mouse assessed as survival days at 30 mg/kg, po QD for 4 days | Plasmodium berghei | 4 | ALA4680079 | organism-based format | Scientific Literature |