# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4706356 | Binding | Antagonist activity at CXCR7 (unknown origin) expressed in human U2OS cells co-expressing beta-arrestin assessed as reduction in CXCL12-alpha induced response pre-incubated for 15 mins before CXCL12-alpha addition and measured after 24 hrs | Homo sapiens | 70 | ALA4699667 | cell-based format | Scientific Literature | |
2. | ALA4706357 | Binding | Inhibition of human ERG expressed in CHO cells at -40 mV holding potential by Q-patch clamp assay | Homo sapiens | 28 | ALA4699667 | cell-based format | Scientific Literature | |
3. | ALA4706358 | Physicochemical | Solubility in FaSSIF-V1 medium | 4 | ALA4699667 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA4706359 | Physicochemical | Solubility in FeSSIF-V1 medium | 4 | ALA4699667 | small-molecule physicochemical format | Scientific Literature | ||
5. | ALA4706360 | Physicochemical | Aqueous solubility at pH 7 | 4 | ALA4699667 | small-molecule physicochemical format | Scientific Literature | ||
6. | ALA4706362 | Physicochemical | Distribution coefficient, logD of compound at pH 7.4 by HPLC based miniaturized shake-flask method | 26 | ALA4699667 | small-molecule physicochemical format | Scientific Literature | ||
7. | ALA4706363 | ADME | Intrinsic clearance in human liver microsomes at 1 uM in presence of NADPH regenerating system incubated up to 45 mins by LC/MS-MS analysis | Homo sapiens | 25 | ALA4699667 | microsome format | Scientific Literature | |
8. | ALA4706366 | ADME | Protein binding in human plasma by LC-MS/MS based equilibrium analysis | Homo sapiens | 24 | ALA4699667 | cell-free format | Scientific Literature | |
9. | ALA4706367 | Physicochemical | Dissociation constant, pKa of compound by potentiometric or spectroscopic titration analysis | 16 | ALA4699667 | small-molecule physicochemical format | Scientific Literature | ||
10. | ALA4706368 | ADME | Inhibition of CYP2C9 in human liver microsomes using diclofenac substrate by LC-MS/MS analysis | Homo sapiens | 1 | ALA4699667 | microsome format | Scientific Literature | |
11. | ALA4706369 | ADME | Inhibition of CYP2D6 in human liver microsomes using dextromethorphan substrate by LC-MS/MS analysis | Homo sapiens | 1 | ALA4699667 | microsome format | Scientific Literature | |
12. | ALA4706370 | ADME | Inhibition of CYP3A4 in human liver microsomes using testosterone substrate by LC-MS/MS analysis | Homo sapiens | 1 | ALA4699667 | microsome format | Scientific Literature | |
13. | ALA4706371 | ADME | Inhibition of CYP3A4 in human liver microsomes using midazolam substrate by LC-MS/MS analysis | Homo sapiens | 1 | ALA4699667 | microsome format | Scientific Literature | |
14. | ALA4706372 | Binding | Binding affinity to SNAP-tag fused human CXCR7 expressed in HEK293 cells by HTRF assay | Homo sapiens | 1 | ALA4699667 | cell-based format | Scientific Literature | |
15. | ALA4706373 | Binding | Binding affinity to SNAP-tag fused human CXCR7 expressed in HEK293 cells assessed as dissociation rate constant by HTRF assay | Homo sapiens | 1 | ALA4699667 | cell-based format | Scientific Literature | |
16. | ALA4706374 | Binding | Binding affinity to SNAP-tag fused human CXCR7 expressed in HEK293 cells assessed as association rate constant by HTRF assay | Homo sapiens | 1 | ALA4699667 | cell-based format | Scientific Literature | |
17. | ALA4706375 | Binding | Binding affinity to SNAP-tag fused human CXCR7 expressed in HEK293 cells assessed as residence time by HTRF assay | Homo sapiens | 1 | ALA4699667 | cell-based format | Scientific Literature | |
18. | ALA4706376 | Binding | Binding affinity to SNAP-tag fused human CXCR7 expressed in HEK293 cells assessed as half life by HTRF assay | Homo sapiens | 1 | ALA4699667 | cell-based format | Scientific Literature | |
19. | ALA4706377 | Binding | Antagonist activity at dog CXCR7 expressed in CHO-K1 cells co-expressing beta-arrestin assessed as reduction in CXCL12-alpha induced response incubated for 24 hrs | Canis lupus familiaris | 1 | ALA4699667 | cell-based format | Scientific Literature | |
20. | ALA4706378 | Binding | Antagonist activity at rat CXCR7 expressed in HEK293 cells co-expressing beta-arrestin assessed as reduction in CXCL12-alpha induced response incubated for 24 hrs | Rattus norvegicus | 1 | ALA4699667 | cell-based format | Scientific Literature |