Antitumour activity against human HeLa cells xenografted in BALB/c nude mouse assessed as reduction in tumour growth at 50 mg/kg, ig administered for alternative days
Antitumour activity against human SKOV-3 cells xenografted in BALB/c nude mouse assessed as reduction in tumour growth at 50 mg/kg, ig administered for alternative days
Antitumour activity against human MCF7 cells xenografted in BALB/c nude mouse assessed as reduction in tumour growth at 50 mg/kg, ig administered for alternative days
Antitumour activity against human A375 cells xenografted in BALB/c nude mouse assessed as reduction in tumour growth at 50 mg/kg, ig administered for alternative days
Antitumour activity against human A431 cells xenografted in BALB/c nude mouse assessed as reduction in tumour growth at 50 mg/kg, ig administered for alternative days
Induction of cell cycle arrest in human HeLa cells assessed as decrease in accumulation in S phase at 1 uM after 24 hrs by RNAse/propidium iodide staining based flow cytometric analysis
Induction of apoptosis in human HeLa cells assessed as viable cells at 1 uM after 24 hrs by Annexin V FITC/propidium iodide staining based flow cytometric analysis (Rvb = 97.97%)
Induction of apoptosis in human HeLa cells assessed as early apoptotic cells at 1 uM after 24 hrs by Annexin V FITC/propidium iodide staining based flow cytometric analysis (Rvb = 0.6%)