| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4716187 | B | Inhibition of ALK (unknown origin) using peptide substrate incubated for 30 mins in presence of ATP by fluorescence assay | Homo sapiens | 27 | single protein format | Scientific Literature | ||
| 2. | ALA4716188 | B | Inhibition of crizotinib-resistant ALK G1202R mutant (unknown origin) using peptide substrate incubated for 30 mins in presence of ATP by fluorescence assay | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 3. | ALA4716189 | B | Inhibition of crizotinib-resistant ALK L1196M mutant (unknown origin) using peptide substrate incubated for 30 mins in presence of ATP by fluorescence assay | Homo sapiens | 27 | single protein format | Scientific Literature | ||
| 4. | ALA4716190 | B | Inhibition of crizotinib-resistant ALK G1269A mutant (unknown origin) using peptide substrate incubated for 30 mins in presence of ATP by fluorescence assay | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 5. | ALA4716191 | B | Inhibition of crizotinib-resistant ALK T1151-L1152 insT mutant (unknown origin) using peptide substrate incubated for 30 mins in presence of ATP by fluorescence assay | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 6. | ALA4716192 | B | Inhibition of crizotinib-resistant ALK F1174L mutant (unknown origin) using peptide substrate incubated for 30 mins in presence of ATP by fluorescence assay | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 7. | ALA4716193 | B | Inhibition of crizotinib-resistant ALK C1156Y mutant (unknown origin) using peptide substrate incubated for 30 mins in presence of ATP by fluorescence assay | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 8. | ALA4716194 | F | Cytotoxicity against human NCI-H2228 cells assessed as reduction in cell viability measured after 72 hrs by SRB assay | Homo sapiens | 27 | cell-based format | Scientific Literature | ||
| 9. | ALA4716195 | F | Cytotoxicity against human NCI-H3122 cells assessed as reduction in cell viability measured after 72 hrs by SRB assay | Homo sapiens | 27 | cell-based format | Scientific Literature | ||
| 10. | ALA4716196 | F | Cytotoxicity against mouse Ba/F3 cells harboring ALK L1196M mutant assessed as reduction in cell viability measured after 72 hrs by WST-1 assay | Mus musculus | 27 | cell-based format | Scientific Literature | ||
| 11. | ALA4716198 | B | Potency index, ratio of LDK378 IC50 to test compound IC50 for inhibition of ALK G1202R mutant (unknown origin) using peptide substrate incubated for 30 mins in presence of ATP by fluorescence assay | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 12. | ALA4716203 | A | Metabolic stability in rat liver microsomes assessed as parent compound remaining at 1 uM incubated for 30 mins in presence of NADP+ by LC-MS/MS analysis | Rattus norvegicus | 3 | microsome format | Scientific Literature | ||
| 13. | ALA4716204 | A | Metabolic stability in human liver microsomes assessed as parent compound remaining at 1 uM incubated for 30 mins in presence of NADP+ by LC-MS/MS analysis | Homo sapiens | 3 | microsome format | Scientific Literature | ||
| 14. | ALA4716206 | A | Cmax in rat at 20 mg/kg, po via gavage by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA4716208 | A | AUC in rat at 20 mg/kg, po via gavage by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA4716209 | B | Inhibition of recombinant N-terminal His6-tagged human ABL (27 to end residues) expressed in baculovirus infected Sf21 insect cells assessed as residual activity at 1 uM relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 17. | ALA4716210 | B | Inhibition of recombinant N-terminal 6His-tagged human ABL M351T mutant (27 to end residues) expressed in baculovirus infected Sf21 insect cells assessed as residual activity at 1 uM relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 18. | ALA4716211 | B | Inhibition of recombinant N-terminal GST-tagged human ACK1 (1 to 389 residues) expressed in baculovirus infected Sf21 insect cells assessed as residual activity at 1 uM relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 19. | ALA4716212 | B | Inhibition of N-terminal His6-tagged human recombinant ALK (1058 to end residues) expressed in baculovirus infected Sf21 cells assessed as residual activity at 1 uM relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 20. | ALA4716213 | B | Inhibition of N-terminal GST-tagged human recombinant ALK4 (150 to end residues) expressed in baculovirus infected Sf21 cells assessed as residual activity at 1 uM relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature |
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