| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4689173 | B | Agonist activity at Gal4-fused RORgammat (unknown origin) expressed in Jurkat cells by reporter assay | Homo sapiens | 21 | ALA4680341 | cell-based format | Scientific Literature | |
| 2. | ALA4689174 | B | Agonist activity at human TRbeta1 CHO-K1 cells by reporter assay | Homo sapiens | 5 | ALA4680341 | cell-based format | Scientific Literature | |
| 3. | ALA4689175 | B | Agonist activity at RORgammat in human Whole blood assessed as increase in IL17 expression after 48 hrs by AlphaLISA | Homo sapiens | 3 | ALA4680341 | tissue-based format | Scientific Literature | |
| 4. | ALA4689176 | B | Agonist activity at RORgammat in C57/B6 mouse Th17 cells assessed as increase in IL17A expression after 96 hrs by AlphaLISA | Mus musculus | 3 | ALA4680341 | cell-based format | Scientific Literature | |
| 5. | ALA4689177 | B | Agonist activity at RORgammat in human Whole blood assessed as increase in IL17F expression after 48 hrs by AlphaLISA | Homo sapiens | 1 | ALA4680341 | tissue-based format | Scientific Literature | |
| 6. | ALA4689178 | B | Agonist activity at RORgammat in C57/B6 mouse Th17 cells assessed as increase in IL17F expression after 96 hrs by AlphaLISA | Mus musculus | 1 | ALA4680341 | cell-based format | Scientific Literature | |
| 7. | ALA4689179 | F | Invivo agonist activity at RORgammat in IL-2/IL23-induced po dosed C57BL/6 mouse assessed as increase in IL-17F production after 30 hrs | Mus musculus | 2 | ALA4680341 | organism-based format | Scientific Literature | |
| 8. | ALA4689180 | A | Stability in human liver microsomes assessed as parent compound remaining at 3 uM after 10 mins by mass spectrometric method | Homo sapiens | 15 | ALA4680341 | microsome format | Scientific Literature | |
| 9. | ALA4689181 | A | Stability in rat liver microsomes assessed as parent compound remaining at 3 uM after 10 mins by mass spectrometric method | Rattus norvegicus | 16 | ALA4680341 | microsome format | Scientific Literature | |
| 10. | ALA4689182 | A | Stability in mouse liver microsomes assessed as parent compound remaining at 3 uM after 10 mins by mass spectrometric method | Mus musculus | 16 | ALA4680341 | microsome format | Scientific Literature | |
| 11. | ALA4689183 | A | Permeability of compound in human Caco-2 cells | Homo sapiens | 3 | ALA4680341 | cell-based format | Scientific Literature | |
| 12. | ALA4689184 | A | Efflux ratio of compound in human Caco-2 cells | Homo sapiens | 3 | ALA4680341 | cell-based format | Scientific Literature | |
| 13. | ALA4689185 | A | Cmax in C57BL/6 mouse at 30 mg/kg, po up to 24 hrs by LC-MS/MS analysis | Mus musculus | 3 | ALA4680341 | organism-based format | Scientific Literature | |
| 14. | ALA4689186 | A | Drug concentration in C57BL/6 mouse at 30 mg/kg, po after 7 hrs by LC-MS/MS analysis | Mus musculus | 3 | ALA4680341 | organism-based format | Scientific Literature | |
| 15. | ALA4689187 | A | Drug concentration in C57BL/6 mouse at 30 mg/kg, po after 24 hrs by LC-MS/MS analysis | Mus musculus | 3 | ALA4680341 | organism-based format | Scientific Literature | |
| 16. | ALA4689188 | A | AUC in C57BL/6 mouse at 30 mg/kg, po up to 24 hrs by LC-MS/MS analysis | Mus musculus | 3 | ALA4680341 | organism-based format | Scientific Literature | |
| 17. | ALA4689189 | F | Antitumour activity against mouse MC38 cells implanted in mouse at 30 mg/kg, po BID | Mus musculus | 2 | ALA4680341 | organism-based format | Scientific Literature | |
| 18. | ALA4689190 | F | Antitumour activity against mouse MC38 cells implanted in mouse at 30 mg/kg, po BID in presence of anti-PD-1 | Mus musculus | 2 | ALA4680341 | organism-based format | Scientific Literature |
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