# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4702076 | B | Protac activity at CRBN/PARP1 in human MDA-MB-436 cells assessed as induction of PARP1 degradation by measuring ratio of PARP1 to beta tubulin protein level at 1 nM incubated for 24 hrs by Western blot analysis (Rvb = 100 No_unit) | Homo sapiens | 14 | ALA4699498 | cell-based format | Scientific Literature | |
2. | ALA4702077 | F | Antiproliferative activity against human MDA-MB-436 cells assessed as cell growth inhibition incubated for 7 days by CCK-8 assay | Homo sapiens | 28 | ALA4699498 | cell-based format | Scientific Literature | |
3. | ALA4702078 | F | Antiproliferative activity against human CAPAN-1 cells assessed as cell growth inhibition incubated for 13 days by by CCK-8 assay | Homo sapiens | 28 | ALA4699498 | cell-based format | Scientific Literature | |
4. | ALA4702079 | B | Protac activity at CRBN/PARP1 in human MDA-MB-436 cells assessed as induction of PARP1 degradation at 1 to 1000 nM incubated for 24 hrs by Western blot analysis | Homo sapiens | 2 | ALA4699498 | cell-based format | Scientific Literature | |
5. | ALA4702080 | B | Protac activity at CRBN/PARP1 in human Capan1 cells assessed as induction of PARP1 degradation at 1 to 1000 nM incubated for 24 hrs by Western blot analysis | Homo sapiens | 2 | ALA4699498 | cell-based format | Scientific Literature | |
6. | ALA4702081 | B | Protac activity at CRBN/PARP1 in human MDA-MB-436 cells assessed as induction of PARP1 degradation at 10 nM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 2 | ALA4699498 | cell-based format | Scientific Literature | |
7. | ALA4702084 | B | Protac activity at CRBN/PARP1 in human MDA-MB-436 cells assessed as induction of PARP1 degradation by measuring ratio of PARP1 to beta tubulin protein level at 10 nM incubated for 24 hrs by Western blot analysis (Rvb = 100 No_unit) | Homo sapiens | 14 | ALA4699498 | cell-based format | Scientific Literature | |
8. | ALA4702085 | B | Protac activity at CRBN/PARP1 in human MDA-MB-436 cells assessed as induction of PARP1 degradation by measuring ratio of PARP1 to beta tubulin protein level at 100 nM incubated for 24 hrs by Western blot analysis (Rvb = 100 No_unit) | Homo sapiens | 14 | ALA4699498 | cell-based format | Scientific Literature | |
9. | ALA4702086 | B | Protac activity at CRBN/PARP1 in human MDA-MB-436 cells assessed as induction of PARP1 degradation by measuring ratio of PARP1 to beta tubulin protein level at 1000 nM incubated for 24 hrs by Western blot analysis (Rvb = 100 No_unit) | Homo sapiens | 14 | ALA4699498 | cell-based format | Scientific Literature | |
10. | ALA4702087 | B | Protac activity at CRBN/PARP1 in human CAPAN-1 cells assessed as induction of PARP1 degradation by measuring ratio of PARP1 to beta tubulin protein level at 1 nM incubated for 24 hrs by Western blot analysis (Rvb = 100 No_unit) | Homo sapiens | 14 | ALA4699498 | cell-based format | Scientific Literature | |
11. | ALA4702088 | B | Protac activity at CRBN/PARP1 in human CAPAN-1 cells assessed as induction of PARP1 degradation by measuring ratio of PARP1 to beta tubulin protein level at 10 nM incubated for 24 hrs by Western blot analysis (Rvb = 100 No_unit) | Homo sapiens | 14 | ALA4699498 | cell-based format | Scientific Literature | |
12. | ALA4702089 | B | Protac activity at CRBN/PARP1 in human CAPAN-1 cells assessed as induction of PARP1 degradation by measuring ratio of PARP1 to beta tubulin protein level at 100 nM incubated for 24 hrs by Western blot analysis (Rvb = 100 No_unit) | Homo sapiens | 14 | ALA4699498 | cell-based format | Scientific Literature | |
13. | ALA4702090 | B | Protac activity at CRBN/PARP1 in human CAPAN-1 cells assessed as induction of PARP1 degradation by measuring ratio of PARP1 to beta tubulin protein level at 1000 nM incubated for 24 hrs by Western blot analysis (Rvb = 100 No_unit) | Homo sapiens | 14 | ALA4699498 | cell-based format | Scientific Literature | |
14. | ALA4702092 | B | Protac activity at VHL/PARP1 in human MDA-MB-436 cells assessed as reduction in PARP1 protein level at 0.01 to 10 uM incubated for 12 hrs by western blot analysis | Homo sapiens | 2 | ALA4699498 | cell-based format | Scientific Literature | |
15. | ALA4702093 | B | Protac activity at VHL/PARP1 in human SW620 cells assessed as reduction in PARP1 protein level at 0.01 to 10 uM incubated for 12 hrs by western blot analysis | Homo sapiens | 2 | ALA4699498 | cell-based format | Scientific Literature | |
16. | ALA4702094 | B | Protac activity at VHL/PARP1 in human MDA-MB-436 cells assessed as PARP1 protein degradation at 1 to 10 nM incubated for 24 hrs by western blot analysis | Homo sapiens | 1 | ALA4699498 | cell-based format | Scientific Literature | |
17. | ALA4702095 | B | Protac activity at VHL/PARP1 in human Capan1 cells assessed as PARP1 protein degradation at 1 to 10 nM incubated for 24 hrs by western blot analysis | Homo sapiens | 1 | ALA4699498 | cell-based format | Scientific Literature | |
18. | ALA4702096 | B | Protac activity at VHL/PARP2 in human MDA-MB-436 cells assessed as induction of PARP2 protein degradation up to 1 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 3 | ALA4699498 | cell-based format | Scientific Literature | |
19. | ALA4702097 | B | Protac activity at VHL/PARP2 in human CAPAN-1 cells assessed as induction of PARP2 protein degradation up to 1 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 3 | ALA4699498 | cell-based format | Scientific Literature | |
20. | ALA4702098 | B | Protac activity at CRBN/PARP1 in human MDA-MB-436 cells assessed as induction of PARP1 degradation incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4699498 | cell-based format | Scientific Literature |