| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4734112 | Binding | Activation of Nrf2 in mouse BV2 cells assessed as decrease in LPS-induced NO production pretreated with compound followed by LPS stimulation after 18 hrs by Griess reagent based assay | Mus musculus | 1 | ALA4732088 | cell-based format | Scientific Literature | |
| 2. | ALA4734113 | Functional | Neuroprotective activity against H2O2-induced cell damage in rat PC12 cells assessed as cell viability at 20 uM after 24 hrs by MTT assay (Rvb = 46 +/- 4.12 %) | Rattus norvegicus | 41 | ALA4732088 | cell-based format | Scientific Literature | |
| 3. | ALA4734114 | Functional | Neuroprotective activity against 6-OHDA-induced cell damage in rat PC12 cells assessed as cell viability at 20 uM after 24 hrs by MTT assay (Rvb = 45.23 +/- 4.37 %) | Rattus norvegicus | 44 | ALA4732088 | cell-based format | Scientific Literature | |
| 4. | ALA4734116 | Functional | Neuroprotective activity against H2O2-induced cell damage in rat PC12 cells preincubated for 24 hrs followed by H2O2 treatment by MTT assay | Rattus norvegicus | 1 | ALA4732088 | cell-based format | Scientific Literature | |
| 5. | ALA4734117 | Functional | Neuroprotective activity against 6-OHDA-induced cell damage in rat PC12 cells preincubated for 24 hrs followed by 6-OHDA treatment by MTT assay | Rattus norvegicus | 1 | ALA4732088 | cell-based format | Scientific Literature | |
| 6. | ALA4734118 | Functional | Cytoprotective activity against H2O2-induced neurotoxicity in rat PC12 cells assessed as reduction in LDH release at 5 to 20 uM preincubated for 24 hrs followed by H2O2 treatment by LDH assay | Rattus norvegicus | 1 | ALA4732088 | cell-based format | Scientific Literature | |
| 7. | ALA4734119 | Functional | Cytoprotective activity against 6-OHDA-induced neurotoxicity in rat PC12 cells assessed as reduction in LDH release at 5 to 20 uM preincubated for 24 hrs followed by 6-OHDA treatment by LDH assay | Rattus norvegicus | 1 | ALA4732088 | cell-based format | Scientific Literature | |
| 8. | ALA4734120 | Functional | Protection against H2O2-induced oxidative damage in rat PC12 cells assessed as intracellular ROS level by measuring mean fluorescence intensity at 5 uM pretreated with compound followed by H2O2 stimulation by DCFH-DA staining based flow cytometry (Rvb = 233032.55 No_unit) | Rattus norvegicus | 1 | ALA4732088 | cell-based format | Scientific Literature | |
| 9. | ALA4734121 | Functional | Protection against H2O2-induced oxidative damage in rat PC12 cells assessed as intracellular ROS level by measuring mean fluorescence intensity at 10 uM pretreated with compound followed by H2O2 stimulation by DCFH-DA staining based flow cytometry (Rvb = 233032.55 No_unit) | Rattus norvegicus | 1 | ALA4732088 | cell-based format | Scientific Literature | |
| 10. | ALA4734122 | Functional | Protection against H2O2-induced oxidative damage in rat PC12 cells assessed as intracellular ROS level by measuring mean fluorescence intensity at 20 uM pretreated with compound followed by H2O2 stimulation by DCFH-DA staining based flow cytometry (Rvb = 233032.55 No_unit) | Rattus norvegicus | 1 | ALA4732088 | cell-based format | Scientific Literature | |
| 11. | ALA4734123 | Functional | Protection against 6-OHDA-induced oxidative damage in rat PC12 cells assessed as intracellular ROS level by measuring mean fluorescence intensity at 5 uM pretreated with compound followed by 6-OHDA stimulation by DCFH-DA staining based flow cytometry (Rvb = 26327.34 No_unit) | Rattus norvegicus | 1 | ALA4732088 | cell-based format | Scientific Literature | |
| 12. | ALA4734124 | Functional | Protection against 6-OHDA-induced oxidative damage in rat PC12 cells assessed as intracellular ROS level by measuring mean fluorescence intensity at 10 uM pretreated with compound followed by 6-OHDA stimulation by DCFH-DA staining based flow cytometry (Rvb = 26327.34 No_unit) | Rattus norvegicus | 1 | ALA4732088 | cell-based format | Scientific Literature | |
| 13. | ALA4734125 | Functional | Protection against 6-OHDA-induced oxidative damage in rat PC12 cells assessed as intracellular ROS level by measuring mean fluorescence intensity at 20 uM pretreated with compound followed by 6-OHDA stimulation by DCFH-DA staining based flow cytometry (Rvb = 26327.34 No_unit) | Rattus norvegicus | 1 | ALA4732088 | cell-based format | Scientific Literature | |
| 14. | ALA4734126 | Functional | Protection against H2O2-induced mitochondrial dysfunction in rat PC12 cells assessed as change in mitochondrial membrane potential at 5 uM pretreated with compound followed by H2O2 addition by JC-1 staining based flow cytometry (Rvb = 78.7 %) | Rattus norvegicus | 1 | ALA4732088 | cell-based format | Scientific Literature | |
| 15. | ALA4734127 | Functional | Protection against H2O2-induced mitochondrial dysfunction in rat PC12 cells assessed as change in mitochondrial membrane potential at 10 uM pretreated with compound followed by H2O2 addition by JC-1 staining based flow cytometry (Rvb = 78.7 %) | Rattus norvegicus | 1 | ALA4732088 | cell-based format | Scientific Literature | |
| 16. | ALA4734128 | Functional | Protection against H2O2-induced mitochondrial dysfunction in rat PC12 cells assessed as change in mitochondrial membrane potential at 20 uM pretreated with compound followed by H2O2 addition by JC-1 staining based flow cytometry (Rvb = 78.7 %) | Rattus norvegicus | 1 | ALA4732088 | cell-based format | Scientific Literature | |
| 17. | ALA4734129 | Functional | Protection against H2O2-induced mitochondrial dysfunction in rat PC12 cells assessed as change in mitochondrial membrane potential loss at 5 uM pretreated with compound followed by H2O2 addition by JC-1 staining based flow cytometry (Rvb = 21.3 %) | Rattus norvegicus | 1 | ALA4732088 | cell-based format | Scientific Literature | |
| 18. | ALA4734130 | Functional | Protection against H2O2-induced mitochondrial dysfunction in rat PC12 cells assessed as change in mitochondrial membrane potential loss at 10 uM pretreated with compound followed by H2O2 addition by JC-1 staining based flow cytometry (Rvb = 21.3 %) | Rattus norvegicus | 1 | ALA4732088 | cell-based format | Scientific Literature | |
| 19. | ALA4734131 | Functional | Protection against H2O2-induced mitochondrial dysfunction in rat PC12 cells assessed as change in mitochondrial membrane potential loss at 20 uM pretreated with compound followed by H2O2 addition by JC-1 staining based flow cytometry (Rvb = 21.3 %) | Rattus norvegicus | 1 | ALA4732088 | cell-based format | Scientific Literature | |
| 20. | ALA4734132 | Functional | Protection against 6-OHDA-induced mitochondrial dysfunction in rat PC12 cells assessed as change in mitochondrial membrane potential at 5 uM pretreated with compound followed by 6-OHDA addition by JC-1 staining based flow cytometry (Rvb = 73.2 %) | Rattus norvegicus | 1 | ALA4732088 | cell-based format | Scientific Literature |
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