#	Aladdin ID	Assay Type	Description	Organism	Compounds	Reference	BAO Format	Source
1.	ALA4673802	Functional	Cytotoxicity against human U20S cells harboring MTH1 siRNA assessed as cell viability measured after 2 days by crystal violet staining based cell counting analysis relative to control	Homo sapiens	3	ALA4673201	cell-based format	Scientific Literature
2.	ALA4673803	Functional	Cytotoxicity against human U20S cells harboring AZ MTH1 siRNA assessed as cell viability measured after 2 days by crystal violet staining based cell counting analysis relative to control	Homo sapiens	3	ALA4673201	cell-based format	Scientific Literature
3.	ALA4673804	Functional	Cytotoxicity against human SW480 cells assessed as cell viability measured after 7 day by Cell-titer glo luciferase assay relative to control	Homo sapiens	3	ALA4673201	cell-based format	Scientific Literature
4.	ALA4673805	Functional	Cytotoxicity against MTH1 knockout human SW480 cells assessed as cell viability measured after 7 day by Cell-titer glo luciferase assay relative to control	Homo sapiens	3	ALA4673201	cell-based format	Scientific Literature
5.	ALA4673806	Functional	Induction of apoptosis in human U2OS cells assessed as increase in cleaved PARP1 level at 10 uM incubated for 24 to 72 hrs by western blot analysis	Homo sapiens	2	ALA4673201	cell-based format	Scientific Literature
6.	ALA4673807	Functional	Induction of DNA damage in human U2OS cells assessed as increase in RPA phosphorylation at Ser4/8 residue at 10 uM incubated for 24 to 72 hrs by western blot analysis	Homo sapiens	2	ALA4673201	cell-based format	Scientific Literature
7.	ALA4673808	Functional	Induction of DNA damage in human U2OS cells assessed as increase in gammaH2AX phosphorylation at 10 uM incubated for 24 to 72 hrs by western blot analysis	Homo sapiens	2	ALA4673201	cell-based format	Scientific Literature
8.	ALA4673809	Functional	Induction of DNA damage in human U2OS cells assessed as increase in p53 phosphorylation at S15 residue at 10 uM incubated for 24 to 72 hrs by western blot analysis	Homo sapiens	2	ALA4673201	cell-based format	Scientific Literature
9.	ALA4673810	Functional	Induction of DNA damage in human U2OS cells assessed as increase in ATM phosphorylation at S1981 residue at 10 uM incubated for 24 to 72 hrs by western blot analysis	Homo sapiens	2	ALA4673201	cell-based format	Scientific Literature
10.	ALA4673811	Functional	Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 7 days by Hoechst 33342 dye based cell counting analysis	Homo sapiens	6	ALA4673201	cell-based format	Scientific Literature
11.	ALA4673812	Functional	Antiproliferative activity against human NCI-H358 cells assessed as cell growth inhibition incubated for 5 days by Hoechst 33342 dye based cell counting analysis	Homo sapiens	6	ALA4673201	cell-based format	Scientific Literature
12.	ALA4673813	Functional	Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 5 days by Hoechst 33342 dye based cell counting analysis	Homo sapiens	6	ALA4673201	cell-based format	Scientific Literature
13.	ALA4673814	Functional	Antiproliferative activity against human U2OS cells assessed as cell growth inhibition incubated for 5 days by Hoechst 33342 dye based cell counting analysis	Homo sapiens	5	ALA4673201	cell-based format	Scientific Literature
14.	ALA4673815	Binding	Binding affinity to MTH1 in human K562 cells assessed as thermal stabilization preincubated for 30 mins followed by heating at 52 degree C for 3 mins by CETSA-based Western blot analysis	Homo sapiens	9	ALA4673201	cell-based format	Scientific Literature
15.	ALA4673816	Binding	Binding affinity to recombinant His-tagged MTH1 isoform p18 (M1 to V156 residues) (unknown origin) assessed as dissociation half life by surface plasmon resonance analysis	Homo sapiens	7	ALA4673201	single protein format	Scientific Literature
16.	ALA4673817	Binding	Binding affinity to recombinant His-tagged MTH1 isoform p18 (M1 to V156 residues) (unknown origin) assessed as dissociation constant by surface plasmon resonance analysis	Homo sapiens	8	ALA4673201	single protein format	Scientific Literature
17.	ALA4673818	ADME	Efflux ratio of permeability in human Caco2 cells	Homo sapiens	4	ALA4673201	cell-based format	Scientific Literature
18.	ALA4673819	ADME	Half-life in Wistar Han rat at 3 micromol/kg, po or 1.5 micromol/kg. iv	Rattus norvegicus	3	ALA4673201	organism-based format	Scientific Literature
19.	ALA4673820	ADME	Apparent permeability of compound in human Caco2 cells	Homo sapiens	4	ALA4673201	cell-based format	Scientific Literature
20.	ALA4673821	ADME	Volume of distribution at steady state in Wistar Han rat at 3 micromol/kg, po or 1.5 micromol/kg. iv	Rattus norvegicus	3	ALA4673201	organism-based format	Scientific Literature