# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4723755 | Binding | Inhibition of STK17A (unknown origin) at 1 uM incubated for 90 mins by Kinase seeker split luciferase assay relative to control | Homo sapiens | 40 | ALA4715866 | single protein format | Scientific Literature | |
2. | ALA4723756 | Binding | Inhibition of N-terminal His-tagged STK17B kinase domain (25 to 329 residues) (unknown origin) expressed in Escherichia coli at 1 uM incubated for 90 mins by Kinase seeker split luciferase assay relative to control | Homo sapiens | 40 | ALA4715866 | assay format | Scientific Literature | |
3. | ALA4723757 | Binding | Inhibition of N-terminal His-tagged STK17B kinase domain (25 to 329 residues) (unknown origin) expressed in Escherichia coli incubated for 90 mins by Kinase seeker split luciferase assay | Homo sapiens | 41 | ALA4715866 | assay format | Scientific Literature | |
4. | ALA4723758 | Binding | Binding affinity to C-terminal nano-luciferase tagged STK17B (unknown origin) expressed in HEK293 cells incubated for 2 hrs by nano-BRET assay based cellular target engagement assay | Homo sapiens | 41 | ALA4715866 | cell-based format | Scientific Literature | |
5. | ALA4723759 | ADME | Stability in mouse liver microsomes assessed as compound remaining at 0.1 mM in presence of NADPH regeneration system after 30 mins by LC-MS/MS analysis | Mus musculus | 15 | ALA4715866 | microsome format | Scientific Literature | |
6. | ALA4723760 | Physicochemical | Kinetic solubility in pH 7.4 PBS | 15 | ALA4715866 | small-molecule physicochemical format | Scientific Literature |