| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4730649 | B | Inhibition of recombinant human C-terminal His-tagged N-terminal GST-tagged PDE4B2 expressed in baculovirus infected Sf9 cells by radioligand binding assay | Homo sapiens | 30 | cell-based format | Scientific Literature | ||
| 2. | ALA4730650 | B | Inhibition of recombinant human N-terminal GST-tagged PDE4D3 expressed in baculovirus infected Sf9 cells by radioligand binding assay | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 3. | ALA4730653 | F | Inhibition of LPS-induced TNFalpha production in C57BL/6 mouse bone marrow derived Macrophage at 1 to 10 uM preincubated for 30 mins followed by LPS stimulation and measured after 24 hrs by ELISA | Mus musculus | 10 | tissue-based format | Scientific Literature | ||
| 4. | ALA4730654 | A | Effect on TNFalpha production in C57BL/6 mouse bone marrow derived Macrophage at 1 to 10 uM incubated for 30 mins by ELISA | Mus musculus | 10 | tissue-based format | Scientific Literature | ||
| 5. | ALA4730655 | A | Metabolic stability in human liver microsomes assessed as intrinsic clearance | Homo sapiens | 11 | microsome format | Scientific Literature | ||
| 6. | ALA4730656 | A | Metabolic stability in mouse liver microsomes assessed as intrinsic clearance | Mus musculus | 11 | microsome format | Scientific Literature | ||
| 7. | ALA4730658 | A | Protein binding in human plasma assessed as unbound fraction | Homo sapiens | 11 | cell-free format | Scientific Literature | ||
| 8. | ALA4730659 | A | Protein binding in mouse plasma assessed as unbound fraction | Mus musculus | 11 | cell-free format | Scientific Literature | ||
| 9. | ALA4730660 | A | Metabolic stability in human Hepatocyte assessed as half life | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 10. | ALA4730661 | A | Metabolic stability in human Hepatocyte assessed as efflux ratio | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 11. | ALA4730662 | B | Inhibition of recombinant human N-terminal GST-tagged PDE1B expressed in baculovirus infected Sf9 cells at 10 uM by radioligand assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4730663 | B | Inhibition of recombinant human N-terminal GST-tagged PDE1A1 expressed in baculovirus infected Sf9 cells at 10 uM by radioligand assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4730664 | B | Inhibition of recombinant human N-terminal GST-tagged PDE1C expressed in baculovirus infected Sf9 cells at 10 uM by radioligand assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4730665 | B | Inhibition of recombinant human N-terminal FLAG-tagged PDE2A1 (2 to 941 residues) expressed in baculovirus infected Sf9 cells at 10 uM by radioligand assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4730666 | B | Inhibition of recombinant human N-terminal His-tagged PDE3A (669 to 1141 end residues) expressed in baculovirus infected Sf9 cells at 10 uM by radioligand assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4730667 | B | Inhibition of recombinant human N-terminal His-tagged PDE3B (592 to end residues) expressed in baculovirus infected Sf9 cells at 10 uM by radioligand assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4730668 | B | Inhibition of recombinant human N-terminal GST-tagged PDE4A1A (1 to 647 residues) expressed in baculovirus infected Sf9 cells at 10 uM by radioligand assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA4730669 | B | Inhibition of recombinant human N-terminal GST-tagged PDE4C1 expressed in baculovirus infected Sf9 cells at 10 uM by radioligand assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA4730670 | B | Inhibition of recombinant human N-terminal GST-tagged PDE4D3 expressed in baculovirus infected Sf9 cells at 10 uM by radioligand assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA4730671 | B | Inhibition of recombinant human N-terminal GST-tagged PDE5A1 expressed in baculovirus infected Sf9 cells at 10 uM by radioligand assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature |
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