| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4704539 | B | Inhibition of recombinant human full length PYK2 at 100 nM in presence of [gamma32P]-ATP by radiometric analysis relative to control | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 2. | ALA4704547 | B | Inhibition of recombinant human N-terminal His-tagged FAK (393 to 698 residues) expressed in baculovirus infected Sf9 insect cells using Poly (4:1 Glu, Tyr) as substrate measured after 1 hr by ADP-glo luminescence assay | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
| 3. | ALA4704548 | B | Covalent inhibition of recombinant human N-terminal His-tagged FAK (393 to 698 residues) expressed in baculovirus infected Sf9 insect cells using Poly (4:1 Glu, Tyr) as substrate preincubated for 2 to 60 mins followed by substrate addition and measured after 1 hr by ADP-glo luminescence assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 4. | ALA4704549 | B | Covalent inhibition of recombinant human N-terminal His-tagged FAK (393 to 698 residues) expressed in baculovirus infected Sf9 insect cells assessed as inactivation rate constant using Poly (4:1 Glu, Tyr) as substrate preincubated for 2 to 60 mins followed by substrate addition and measured after 1 hr by ADP-glo luminescence assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 5. | ALA4704550 | B | Covalent inhibition of recombinant human N-terminal His-tagged FAK (393 to 698 residues) expressed in baculovirus infected Sf9 insect cells assessed as ratio of Kinact to Ki using Poly (4:1 Glu, Tyr) as substrate preincubated for 2 to 60 mins followed by substrate addition and measured after 1 hr by ADP-glo luminescence assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 6. | ALA4704554 | B | Inhibition of human recombinant Src at 100 nM in presence of [gamma33P]ATP by radiometric assay relative to control | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 7. | ALA4704555 | B | Inhibition of human recombinant FGFR1 (456 to 765 residues) at 100 nM in presence of [gamma33P]ATP by radiometric assay relative to control | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 8. | ALA4704556 | B | Inhibition of human recombinant c-kit at 100 nM in presence of [gamma33P]ATP by radiometric assay relative to control | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 9. | ALA4704557 | B | Inhibition of human recombinant EGFR at 100 nM in presence of [gamma33P]ATP by radiometric assay relative to control | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 10. | ALA4704558 | B | Inhibition of human recombinant IGF1R at 100 nM by [gamma-33ATP] radiometric assay relative to control | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 11. | ALA4704559 | B | Inhibition of human recombinant PDGFRA at 100 nM by [gamma-33ATP] radiometric assay relative to control | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 12. | ALA4704560 | B | Inhibition of human recombinant IR at 100 nM by [gamma-33ATP] radiometric analysis relative to control | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 13. | ALA4704561 | B | Inhibition of human Akt at 100 nM in presence of [33P]-ATP by radiometric analysis relative to control | Homo sapiens | 4 | protein format | Scientific Literature | ||
| 14. | ALA4704562 | B | Inhibition of human recombinant Erk at 100 nM measured in presence of [33P]-ATP by radiometric analysis relative to control | Homo sapiens | 4 | assay format | Scientific Literature | ||
| 15. | ALA4704563 | B | Inhibition of human recombinant FAK at 100 nM by [gamma32P]-ATP radiometric analysis relative to control | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 16. | ALA4704564 | B | Inhibition of FAK autophosphorylation at Tyr397 residue in human U87MG cells after 48 hrs by ELISA | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 17. | ALA4704565 | B | Inhibition of FAK autophosphorylation at Tyr397 residue in human U87MG cells after 48 hrs by Western blot analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 18. | ALA4704566 | B | Reversible inhibition of FAK phosphorylation at Tyr397 residue in human U87MG assessed as recovery of FAK autophosphorylation at 0.1 to 5 uM incubated for 48 hrs followed by compound washout with PBS measured by Western blot analysis | Homo sapiens | 4 | tissue-based format | Scientific Literature | ||
| 19. | ALA4704567 | A | Cytotoxicity against human U-87 MG cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 20. | ALA4704568 | A | Cytotoxicity against human A172 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay | Homo sapiens | 5 | cell-based format | Scientific Literature |
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