| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4718820 | B | Inhibition of human EGFR using poly[Glu:Tyr] (4:1) as substrate in presence of [gamma33P]ATP by radiometric HotSpot assay | Homo sapiens | 46 | ALA4715760 | single protein format | Scientific Literature | |
| 2. | ALA4718821 | A | Apparent permeability from apical to basolateral side in human Caco2 cells at 10 uM measured for 120 mins by LC-MS/MS analysis | Homo sapiens | 29 | ALA4715760 | cell-based format | Scientific Literature | |
| 3. | ALA4718822 | A | Efflux ratio of apparent permeability across basolateral to apical side over apical to basolateral side in human Caco2 cells at 10 uM measured for 120 mins by LC-MS/MS analysis | Homo sapiens | 29 | ALA4715760 | cell-based format | Scientific Literature | |
| 4. | ALA4718823 | A | Metabolic stability in pooled human liver microsomes assessed as half life at 3 uM measured up to 45 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 30 | ALA4715760 | microsome format | Scientific Literature | |
| 5. | ALA4718824 | A | Protein binding in plasma (unknown origin) assessed as unbound fraction at 5 uM by LC-MS/MS based equilibrium dialysis analysis | Not specified | 11 | ALA4715760 | cell-free format | Scientific Literature | |
| 6. | ALA4718825 | P | Aqueous solubility of compound in phosphate buffered saline at pH 7.4 incubated for 2 hrs by turbidimetric analysis | 29 | ALA4715760 | small-molecule physicochemical format | Scientific Literature | ||
| 7. | ALA4718826 | A | Inhibition of human ERG expressed in CHO cells at -80 mV holding potential by IonWorks patch-clamp electrophysiology assay | Homo sapiens | 11 | ALA4715760 | cell-based format | Scientific Literature | |
| 8. | ALA4718827 | F | Antiproliferative activity against mouse Ba/F3 cells expressing EGFR-L858R mutant assessed as inhibition of cell growth incubated for 48 hrs by XTT assay | Mus musculus | 11 | ALA4715760 | cell-based format | Scientific Literature | |
| 9. | ALA4718829 | F | Antiproliferative activity against human A431 cells assessed as inhibition of cell growth incubated for 72 hrs by Cell Titer Glo luminescent cell viability assay | Homo sapiens | 1 | ALA4715760 | cell-based format | Scientific Literature | |
| 10. | ALA4718839 | B | Inhibition of EGFR (unknown origin) at 100 nM using Tyr 04 peptide as substrate incubated for 1 hr by Z'-LYTE assay relative to control | Homo sapiens | 4 | ALA4715760 | single protein format | Scientific Literature | |
| 11. | ALA4718840 | B | Inhibition of EGFR (unknown origin) using Tyr 04 peptide as substrate incubated for 1 hr by Z'-LYTE assay | Homo sapiens | 4 | ALA4715760 | single protein format | Scientific Literature | |
| 12. | ALA4718841 | A | Apparent permeability from basolateral to apical side in human Caco2 cells at 10 uM measured for 120 mins by LC-MS/MS analysis | Homo sapiens | 29 | ALA4715760 | cell-based format | Scientific Literature | |
| 13. | ALA4718842 | A | Metabolic stability in pooled human liver microsomes assessed as Clearance at 3 uM measured up to 45 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 30 | ALA4715760 | microsome format | Scientific Literature | |
| 14. | ALA4718843 | B | Inhibition of recombinant full length human His-tagged ABL1 cytoplasmic domain expressed in baculovirus expression system at 500 nM using Tyr 02 peptide as substrate incubated for 1 hr in presence of ATP at its Km concentration by Z'-LYTE assay relative to control | Homo sapiens | 6 | ALA4715760 | assay format | Scientific Literature | |
| 15. | ALA4718844 | B | Inhibition of recombinant human full length His-tagged AURKA expressed in baculovirus expression system at 500 nM using Ser/Thr 01 as substrate incubated for 1 hr in presence of ATP at its Km concentration by Z'-LYTE assay relative to control | Homo sapiens | 6 | ALA4715760 | assay format | Scientific Literature | |
| 16. | ALA4718845 | B | Inhibition of recombinant full length His-tagged human AURKB expressed in baculovirus expression system at 500 nM using Ser/Thr 01 as substrate incubated for 1 hr in presence of ATP at its Km concentration by Z'-LYTE assay relative to control | Homo sapiens | 6 | ALA4715760 | assay format | Scientific Literature | |
| 17. | ALA4718846 | B | Inhibition of recombinant human His-tagged full length BLK expressed in baculovirus expression system at 500 nM using Tyr 01 peptide as substrate incubated for 1 hr in presence of ATP at its Km concentration by Z'-LYTE assay relative to control | Homo sapiens | 6 | ALA4715760 | assay format | Scientific Literature | |
| 18. | ALA4718847 | B | Inhibition of recombinant human GST-tagged full length BRAF expressed in baculovirus expression system at 500 nM using Ser/Thr 03 peptide as substrate incubated for 1 hr in presence of 100 uM ATP by Z'-LYTE assay relative to control | Homo sapiens | 6 | ALA4715760 | assay format | Scientific Literature | |
| 19. | ALA4718848 | B | Inhibition of recombinant human full-length His-tagged CHEK1 expressed in baculovirus expression system at 500 nM using Ser/Thr 19 peptide as substrate incubated for 1 hr in presence of ATP at its Km concentration by Z'-LYTE assay relative to control | Homo sapiens | 6 | ALA4715760 | assay format | Scientific Literature | |
| 20. | ALA4718849 | B | Inhibition of recombinant human His-tagged CSF1R (538 to 910 residues) expressed in baculovirus expression system at 500 nM using Tyr 01 peptide as substrate incubated for 1 hr in presence of ATP at its Km concentration by Z'-LYTE assay relative to control | Homo sapiens | 6 | ALA4715760 | assay format | Scientific Literature |
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