# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4723257 | Binding | Displacement of reporter probe from human recombinant FGFR4 (391 to 802) expressed in Baculovirus infected Sf9 cells assessed as residence time measured after 30 mins by proteros reporter displacement assay | Homo sapiens | 7 | ALA4715854 | cell-based format | Scientific Literature | |
2. | ALA4723258 | Binding | Displacement of reporter probe from human recombinant FGFR4 (391 to 802) expressed in Baculovirus infected Sf9 cells assessed as dissociation rate constant measured after 30 mins by proteros reporter displacement assay | Homo sapiens | 7 | ALA4715854 | cell-based format | Scientific Literature | |
3. | ALA4723259 | Binding | Displacement of reporter probe from human recombinant FGFR4 (391 to 802) expressed in Baculovirus infected Sf9 cells assessed as association rate constant measured after 30 mins by proteros reporter displacement assay | Homo sapiens | 7 | ALA4715854 | cell-based format | Scientific Literature | |
4. | ALA4723260 | Binding | Displacement of reporter probe from human recombinant FGFR4 (391 to 802) expressed in Baculovirus infected Sf9 cells measured after 30 mins by proteros reporter displacement assay | Homo sapiens | 7 | ALA4715854 | cell-based format | Scientific Literature | |
5. | ALA4723292 | ADME | Hepatic extraction ratio in rat liver microsomes preincubated for 3 mins followed by NADPH addition and measured after 60 mins | Rattus norvegicus | 80 | ALA4715854 | microsome format | Scientific Literature | |
6. | ALA4723293 | Functional | Antiproliferative activity against human HuH7 cells assessed as reduction in cell viability incubated for 3 days by cell proliferation assay | Homo sapiens | 41 | ALA4715854 | cell-based format | Scientific Literature | |
7. | ALA4723295 | Binding | Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation incubated for 40 mins | Mus musculus | 76 | ALA4715854 | cell-based format | Scientific Literature | |
8. | ALA4723314 | Binding | Inhibition of recombinant non-phosphorylated FGFR4 kinase domain (442 to 753) (unknown origin) expressed in Sf9 insect cells using 5-Fluo-Ahx-KKKKEEIYFFFG-NH2 peptide as substrate in presence of ATP measured after 60 mins by caliper microfluidic mobility shift assay | Homo sapiens | 82 | ALA4715854 | cell-based format | Scientific Literature | |
9. | ALA4723316 | Unassigned | Selectivity ratio of IC50 for antiproliferative activity against human HuH7 cells to IC50 for inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation | 4 | ALA4715854 | cell-based format | Scientific Literature |