# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4728534 | B | Inhibition of recombinant human soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins followed by substrate addition and measured at 30 secs interval for 10 mins by fluorescence assay | Homo sapiens | 22 | ALA4725350 | single protein format | Scientific Literature | |
2. | ALA4728535 | P | Solubility of the compound in 1% DMSO/99% PBS buffer solution measured after 2 hrs by light scattering based assay | 9 | ALA4725350 | small-molecule physicochemical format | Scientific Literature | ||
3. | ALA4728539 | B | Inhibition of recombinant mouse soluble epoxide hydrolase using CMNPC as substrate preincubated for 5 mins followed by substrate addition and measured at 30 secs interval for 10 mins by fluorescence assay | Mus musculus | 18 | ALA4725350 | single protein format | Scientific Literature | |
4. | ALA4728540 | A | Cytotoxicity against human PBMC assessed as reduction in cell viability measured after 72 hrs by ATPlite assay | Homo sapiens | 4 | ALA4725350 | tissue-based format | Scientific Literature | |
5. | ALA4728541 | A | Cytotoxicity against human THLE-2 cells assessed as reduction in cell viability measured after 72 hrs by ATPlite assay | Homo sapiens | 4 | ALA4725350 | cell-based format | Scientific Literature | |
6. | ALA4728542 | A | Stability in human liver microsomes assessed as parent compound remaining measured after 60 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 4 | ALA4725350 | microsome format | Scientific Literature | |
7. | ALA4728543 | A | Stability in mouse liver microsomes assessed as parent compound remaining measured after 60 mins in presence of NADPH by LC-MS/MS analysis | Mus musculus | 4 | ALA4725350 | microsome format | Scientific Literature | |
8. | ALA4728544 | A | Stability in rat liver microsomes assessed as parent compound remaining measured after 60 mins in presence of NADPH by LC-MS/MS analysis | Rattus norvegicus | 4 | ALA4725350 | microsome format | Scientific Literature | |
9. | ALA4728545 | A | Inhibition of recombinant human CYP1A2 at >10 uM preincubated for 5 mins followed by substrate addition by fluorescence assay | Homo sapiens | 2 | ALA4725350 | single protein format | Scientific Literature | |
10. | ALA4728546 | A | Inhibition of recombinant human CYP2C9 at >10 uM preincubated for 5 mins followed by substrate addition by fluorescence assay | Homo sapiens | 2 | ALA4725350 | single protein format | Scientific Literature | |
11. | ALA4728547 | A | Inhibition of recombinant human CYP2C19 at >10 uM preincubated for 5 mins followed by substrate addition by fluorescence assay | Homo sapiens | 2 | ALA4725350 | single protein format | Scientific Literature | |
12. | ALA4728548 | A | Inhibition of recombinant human CYP2D6 at >10 uM preincubated for 5 mins followed by substrate addition by fluorescence assay | Homo sapiens | 2 | ALA4725350 | single protein format | Scientific Literature | |
13. | ALA4728549 | A | Inhibition of recombinant human CYP3A4 at >10 uM using 7-BFC as substrate preincubated for 5 mins followed by substrate addition by fluorescence assay | Homo sapiens | 2 | ALA4725350 | single protein format | Scientific Literature | |
14. | ALA4728550 | A | Inhibition of recombinant human CYP3A4 at >10 uM using DBF as substrate preincubated for 5 mins followed by substrate addition by fluorescence assay | Homo sapiens | 2 | ALA4725350 | single protein format | Scientific Literature | |
15. | ALA4728551 | B | Selectivity ratio of inhibition of recombinant human CYP1A2 to IC50 for inhibition of recombinant human soluble epoxide hydrolase | Homo sapiens | 2 | ALA4725350 | assay format | Scientific Literature | |
16. | ALA4728552 | B | Selectivity ratio of inhibition of recombinant human CYP2C9 to IC50 for inhibition of recombinant human soluble epoxide hydrolase | Homo sapiens | 2 | ALA4725350 | assay format | Scientific Literature | |
17. | ALA4728553 | B | Selectivity ratio of inhibition of recombinant human CYP2C19 to IC50 for inhibition of recombinant human soluble epoxide hydrolase | Homo sapiens | 2 | ALA4725350 | assay format | Scientific Literature | |
18. | ALA4728554 | B | Selectivity ratio of inhibition of recombinant human CYP2D6 to IC50 for inhibition of recombinant human soluble epoxide hydrolase | Homo sapiens | 2 | ALA4725350 | assay format | Scientific Literature | |
19. | ALA4728555 | B | Selectivity ratio of inhibition of recombinant human CYP3A4 to IC50 for inhibition of recombinant human soluble epoxide hydrolase using 7-BFC as substrate | Homo sapiens | 2 | ALA4725350 | assay format | Scientific Literature | |
20. | ALA4728556 | B | Selectivity ratio of inhibition of recombinant human CYP3A4 to IC50 for inhibition of recombinant human soluble epoxide hydrolase using DBF as substrate | Homo sapiens | 2 | ALA4725350 | assay format | Scientific Literature |