# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4677851 | Binding | Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as fold change in dopamine Emax for beta-arrestin2 recruitment at 50 uM incubated for 90 mins by PathHunter assay relative to control | Homo sapiens | 25 | ALA4673311 | cell-based format | Scientific Literature | |
2. | ALA4677852 | Binding | Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as fold change in dopamine EC50 for beta-arrestin2 recruitment at 50 uM incubated for 90 mins by PathHunter assay relative to control | Homo sapiens | 25 | ALA4673311 | cell-based format | Scientific Literature | |
3. | ALA4677853 | Binding | Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as fold change in dopamine Emax for beta-arrestin2 recruitment at 50 uM incubated for 90 mins by PathHunter assay relative to control | Homo sapiens | 25 | ALA4673311 | cell-based format | Scientific Literature | |
4. | ALA4677854 | Binding | Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as fold change in dopamine EC50 for beta-arrestin2 recruitment at 50 uM incubated for 90 mins by PathHunter assay relative to control | Homo sapiens | 25 | ALA4673311 | cell-based format | Scientific Literature | |
5. | ALA4677855 | Functional | Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as fold change in dopamine EC50 for cAMP accumulation at 50 uM measured after 30 mins by HitHunter assay relative to control | Homo sapiens | 25 | ALA4673311 | cell-based format | Scientific Literature | |
6. | ALA4677856 | Binding | Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine Emax at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 102 +/- 1.6 %) | Homo sapiens | 25 | ALA4673311 | cell-based format | Scientific Literature | |
7. | ALA4677857 | Binding | Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM) | Homo sapiens | 25 | ALA4673311 | cell-based format | Scientific Literature | |
8. | ALA4677858 | Binding | Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine Emax at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 99.4 +/- 0.5 %) | Homo sapiens | 25 | ALA4673311 | cell-based format | Scientific Literature | |
9. | ALA4677859 | Binding | Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM) | Homo sapiens | 25 | ALA4673311 | cell-based format | Scientific Literature | |
10. | ALA4677860 | Functional | Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine Emax at 50 uM measured after 30 mins by HitHunter assay (Rvb = 100 +/- 3.4 %) | Homo sapiens | 25 | ALA4673311 | cell-based format | Scientific Literature | |
11. | ALA4677861 | Functional | Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM) | Homo sapiens | 25 | ALA4673311 | cell-based format | Scientific Literature | |
12. | ALA4677862 | Functional | Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as fold change in dopamine Emax for cAMP accumulation at 50 uM measured after 30 mins by HitHunter assay relative to control | Homo sapiens | 25 | ALA4673311 | cell-based format | Scientific Literature |