| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4711228 | F | Induction of cell cycle arrest in human HeLa cells assessed as accumulation at G0/G1 phase at 1 uM incubated for 24 hrs by PI staining based flowcytometry analysis (Rvb = 57 %) | Homo sapiens | 1 | ALA4706596 | cell-based format | Scientific Literature | |
| 2. | ALA4711229 | F | Antiproliferative activity against human HeLa cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay | Homo sapiens | 22 | ALA4706596 | cell-based format | Scientific Literature | |
| 3. | ALA4711230 | F | Antiproliferative activity against human HT-29 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay | Homo sapiens | 22 | ALA4706596 | cell-based format | Scientific Literature | |
| 4. | ALA4711231 | F | Antiproliferative activity against human RS4-11 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay | Homo sapiens | 22 | ALA4706596 | cell-based format | Scientific Literature | |
| 5. | ALA4711232 | F | Antiproliferative activity against human CCRF-CEM cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay | Homo sapiens | 22 | ALA4706596 | cell-based format | Scientific Literature | |
| 6. | ALA4711237 | B | Binding affinity to human CKalpha1 assessed as dissociation constant by spectroflurometry | Homo sapiens | 12 | ALA4706596 | single protein format | Scientific Literature | |
| 7. | ALA4711238 | B | Binding affinity to human CKbeta assessed as dissociation constant by spectroflurometry | Homo sapiens | 4 | ALA4706596 | single protein format | Scientific Literature | |
| 8. | ALA4711239 | B | Selectivity index, ratio of Kd for human CKbeta to Kd for human CKalpha1 | Homo sapiens | 4 | ALA4706596 | assay format | Scientific Literature | |
| 9. | ALA4711240 | B | Inhibition of human CKalpha1 assessed as reduction in 14C incorporation from [methyl-14C]choline to phosphatidylcholine at 10 uM using [methyl-14C]choline as substrate preincubated for 5 mins in presence of ATP and MgCl2 followed by substrate addition and measured after 10 mins by liquid scintillation counting method relative to control | Homo sapiens | 14 | ALA4706596 | single protein format | Scientific Literature | |
| 10. | ALA4711241 | B | Inhibition of human CKalpha1 assessed as reduction in 14C incorporation from [methyl-14C]choline to phosphatidylcholine at 30 uM using [methyl-14C]choline as substrate preincubated for 5 mins in presence of ATP and MgCl2 followed by substrate addition and measured after 10 mins by liquid scintillation counting method relative to control | Homo sapiens | 17 | ALA4706596 | single protein format | Scientific Literature | |
| 11. | ALA4711243 | B | Inhibition of human CKalpha1 assessed as reduction in 14C incorporation from [methyl-14C]choline to phosphatidylcholine using [methyl-14C]choline as substrate preincubated for 5 mins in presence of ATP and MgCl2 followed by substrate addition and measured after 10 mins by liquid scintillation counting method relative to control | Homo sapiens | 2 | ALA4706596 | single protein format | Scientific Literature | |
| 12. | ALA4711244 | F | Inhibition of [methyl-14C]choline uptake in human HT-29 cells at 10 uM incubated for 10 mins followed by removal of medium containing compound and subsequent addition of [methyl-14C]choline measured after 5 mins relative to control | Homo sapiens | 7 | ALA4706596 | cell-based format | Scientific Literature | |
| 13. | ALA4711245 | F | Inhibition of [methyl-14C]choline uptake in human HT-29 cells at 30 uM incubated for 10 mins followed by removal of medium containing compound and subsequent addition of [methyl-14C]choline measured after 5 mins relative to control | Homo sapiens | 7 | ALA4706596 | cell-based format | Scientific Literature | |
| 14. | ALA4711246 | F | Inhibition of [methyl-14C]choline uptake in human HepG2 cells at 10 uM incubated for 10 mins followed by removal of medium containing compound and subsequent addition of [methyl-14C]choline measured after 5 mins relative to control | Homo sapiens | 7 | ALA4706596 | cell-based format | Scientific Literature | |
| 15. | ALA4711247 | F | Inhibition of [methyl-14C]choline uptake in human HepG2 cells at 30 uM incubated for 10 mins followed by removal of medium containing compound and subsequent addition of [methyl-14C]choline measured after 5 mins relative to control | Homo sapiens | 7 | ALA4706596 | cell-based format | Scientific Literature | |
| 16. | ALA4711248 | F | Induction of cell cycle arrest in human HeLa cells assessed as accumulation at S phase at 1 uM incubated for 24 hrs by PI staining based flowcytometry analysis (Rvb = 32.30 %) | Homo sapiens | 1 | ALA4706596 | cell-based format | Scientific Literature | |
| 17. | ALA4711249 | F | Induction of cell cycle arrest in human HeLa cells assessed as accumulation at G2/M phase at 1 uM incubated for 24 hrs by PI staining based flowcytometry analysis (Rvb = 10.7 %) | Homo sapiens | 1 | ALA4706596 | cell-based format | Scientific Literature | |
| 18. | ALA4711250 | F | Induction of cell cycle arrest in human HeLa cells assessed as accumulation at G0/G1 phase at 2.5 uM incubated for 24 hrs by PI staining based flowcytometry analysis (Rvb = 57 %) | Homo sapiens | 1 | ALA4706596 | cell-based format | Scientific Literature | |
| 19. | ALA4711251 | F | Induction of cell cycle arrest in human HeLa cells assessed as accumulation at S phase at 2.5 uM incubated for 24 hrs by PI staining based flowcytometry analysis (Rvb = 32.30 %) | Homo sapiens | 1 | ALA4706596 | cell-based format | Scientific Literature | |
| 20. | ALA4711252 | F | Induction of cell cycle arrest in human HeLa cells assessed as accumulation at G2/M phase at 2.5 uM incubated for 24 hrs by PI staining based flowcytometry analysis (Rvb = 10.70 %) | Homo sapiens | 1 | ALA4706596 | cell-based format | Scientific Literature |
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