# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4689490 | Binding | Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFARKGSLRQKNV-COOH as substrate incubated for 3 hrs in presence of ATP by by capillary electrophoresis method | Homo sapiens | 24 | ALA4680358 | cell-based format | Scientific Literature | |
2. | ALA4689491 | Binding | Inhibition of IRAK4 (unknown origin) | Homo sapiens | 24 | ALA4680358 | single protein format | Scientific Literature | |
3. | ALA4689492 | Binding | Inhibition of GLK (unknown origin) | Homo sapiens | 22 | ALA4680358 | single protein format | Scientific Literature | |
4. | ALA4689493 | Binding | Selectivity index, ratio of IC50 for IRAK4 (unknown origin) to IC50 for recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells | Homo sapiens | 22 | ALA4680358 | cell-based format | Scientific Literature | |
5. | ALA4689494 | Binding | Selectivity index, ratio of IC50 for GLK (unknown origin) to IC50 for recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells | Homo sapiens | 22 | ALA4680358 | cell-based format | Scientific Literature | |
6. | ALA4689495 | Binding | Inhibition of HPK1 in anti-CD3/anti-CD28-stimulated human T-cells assessed as inhibition of SLP76 phosphorylation preincubated for 1 hr followed by anti-CD3/CD28 stimulation for 30 mins by AlphaLISA assay | Homo sapiens | 14 | ALA4680358 | tissue-based format | Scientific Literature | |
7. | ALA4689496 | ADME | Protein binding in human plasma assessed as free fraction | Homo sapiens | 14 | ALA4680358 | cell-free format | Scientific Literature | |
8. | ALA4689497 | ADME | Protein binding in mouse plasma assessed as free fraction | Mus musculus | 5 | ALA4680358 | cell-free format | Scientific Literature | |
9. | ALA4689498 | ADME | Microsomal stability in human liver microsomes assessed as parent compound remaining after 10 mins | Homo sapiens | 5 | ALA4680358 | microsome format | Scientific Literature | |
10. | ALA4689499 | ADME | Microsomal stability in mouse liver microsomes assessed as parent compound remaining after 10 mins | Mus musculus | 14 | ALA4680358 | microsome format | Scientific Literature |