| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4722767 | B | Inhibition of rat FPPS expressed in Escherichia coli BL21 (DE3) using GPP and IPP as substrate at 10 uM incubated for 10 mins by microplate reader | Rattus norvegicus | 10 | assay format | Scientific Literature | ||
| 2. | ALA4722768 | B | Binding affinity to rat FPPS expressed in Escherichia coli BL21 (DE3) by isothermal titration calorimetry | Rattus norvegicus | 10 | assay format | Scientific Literature | ||
| 3. | ALA4722769 | F | Growth inhibition of human LoVo cells at 100 uM incubated for 48 hrs by MTT assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA4722770 | F | Growth inhibition of human HCT116 cells at 100 uM incubated for 48 hrs by MTT assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA4722771 | F | Growth inhibition of human MDA-MB-468 cells at 100 uM incubated for 48 hrs by MTT assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA4722772 | F | Cytotoxicity against FPPS-positive human Lovo cells assessed as reduction in cell viability measured after 48 hrs by MTT assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 7. | ALA4722773 | F | Cytotoxicity against FPPS-positive human HCT116 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 8. | ALA4722774 | F | Cytotoxicity against FPPS-negative human MDA-MB-231 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 9. | ALA4722775 | F | Cytotoxicity against FPPS-positive human Lovo cells assessed as cell viability at 100 uM in presence of FOH measured after 48 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4722776 | F | Cytotoxicity against FPPS-positive human Lovo cells assessed as cell viability at 100 uM in presence of GGOH measured after 48 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4722777 | F | Cytotoxicity against FPPS-positive human HCT116 cells assessed as cell viability at 100 uM in presence of FOH measured after 48 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4722778 | F | Cytotoxicity against FPPS-positive human HCT116 cells assessed as cell viability at 100 uM in presence of GGOH measured after 48 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4722779 | F | Reduction in Ras protein expression in FPPS-positive human LoVo cells upto 75 uM measured after 48 hrs by Western blot analysis | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 14. | ALA4722780 | F | Reduction in Ras protein expression in FPPS-positive human HCT116 cells upto 75 uM measured after 48 hrs by Western blot analysis | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 15. | ALA4722781 | F | Induction of ROS generation in human Lovo cells assessed as intracellular ROS level at 75 uM by DCFH-DA staining-based flow cytometric analysis (Rvb = 9.18%) | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4722782 | F | Induction of ROS generation in human HCT116 cells assessed as intracellular ROS level at 75 uM by DCFH-DA staining-based flow cytometric analysis (Rvb = 8.91%) | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4722783 | F | Induction of apoptosis in human Lovo cells assessed as viable cells at 25 uM after 48 hrs by Annexin V/FITC staining based flow cytometric analysis (Rvb = 91.1%) | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA4722784 | F | Induction of apoptosis in human Lovo cells assessed as early apoptotic cells at 25 uM after 48 hrs by Annexin V/FITC staining based flow cytometric analysis (Rvb = 6.76%) | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA4722785 | F | Induction of apoptosis in human Lovo cells assessed as late apoptotic cells at 25 uM after 48 hrs by Annexin V/FITC staining based flow cytometric analysis (Rvb = 1.84%) | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA4722786 | F | Induction of apoptosis in human Lovo cells assessed as necrotic cells at 25 uM after 48 hrs by Annexin V/FITC staining based flow cytometric analysis (Rvb = 0.321%) | Homo sapiens | 1 | cell-based format | Scientific Literature |
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