| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4775584 | B | Inhibition of Sialyltransferase in human MDA-MB-231 cells assessed as decrease p-talin-1 association with integrins beta1 and beta 3 after 48 hrs by immunofluorescence and coimmunoprecipitation assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 2. | ALA4775585 | B | Inhibition of rat alpha-2,3-N-ST3GALIII assessed as reduction in sialylated-product formation using Gal-beta1-4Glc and CMP-NeuSAc incubated for 1.5 hrs by reverse-phase HPLC analysis | Rattus norvegicus | 19 | single protein format | Scientific Literature | ||
| 3. | ALA4775586 | B | Inhibition of human alpha-2,6-ST6GAL1 assessed as reduction in sialylated-product formation using Gal-beta1-4GlcNac and CMP-NeuSAc incubated for 15 mins by reverse-phase HPLC analysis | Homo sapiens | 17 | single protein format | Scientific Literature | ||
| 4. | ALA4775588 | B | Inhibition of rat alpha-2,3-O-ST3GALI assessed as reduction in sialylated-product formation at 500 uM using p-nitrophenyl T-antigen and CMP-NeuSAc incubated for 15 mins by reverse-phase HPLC analysis relative to control | Rattus norvegicus | 17 | single protein format | Scientific Literature | ||
| 5. | ALA4775589 | B | Inhibition of rat alpha-2,3-O-ST3GALI assessed as reduction in sialylated-product formation at 1 mM using p-nitrophenyl T-antigen and CMP-NeuSAc incubated for 15 mins by reverse-phase HPLC analysis relative to control | Rattus norvegicus | 5 | single protein format | Scientific Literature | ||
| 6. | ALA4775591 | B | Selectivity ratio of inhibition of rat alpha-2,3-O-ST3GALI at 500 uM to IC50 for inhibition of rat alpha-2,3-N-ST3GALIII | Rattus norvegicus | 5 | assay format | Scientific Literature | ||
| 7. | ALA4775592 | B | Selectivity ratio of inhibition of rat alpha-2,3-O-ST3GALI at 1000 uM to IC50 for inhibition of rat alpha-2,3-N-ST3GALIII | Rattus norvegicus | 3 | assay format | Scientific Literature | ||
| 8. | ALA4775594 | B | Selectivity ratio of IC50 for of inhibition of rat alpha-2,3-O-ST3GALI to IC50 for inhibition of human alpha-2,6-ST6GAL1 | 17 | assay format | Scientific Literature | |||
| 9. | ALA4775595 | T | Toxicity in human MDA-MB-231 cells assessed as cell survival at >60 uM relative to control | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
| 10. | ALA4775596 | F | Inhibition of serum-induced cell migration of human MDA-MB-231 cells incubated for 16 hrs by Boyden chamber assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 11. | ALA4775597 | F | Inhibition of serum-induced cell migration of human MDA-MB-231 cells at 20 uM incubated for 16 hrs by Boyden chamber assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 12. | ALA4775598 | B | Inhibition of Sialyltransferase in human MDA-MB-231 cells assessed as suppression of sialylation of integrin subunit beta1/beta3/beta4/beta5 at 10 to 20 um after 48 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 13. | ALA4775615 | B | Inhibition of Sialyltransferase in human MDA-MB-231 cells assessed as reduction in integrin isoforms expression (alphaV/alpha5/beta1/beta3/beta4/beta5) at 10 to 20 uM incubated for 48 hrs by immunoblot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 14. | ALA4775616 | B | Inhibition of Sialyltransferase in human MDA-MB-231 cells assessed as reduction in FAK Tyr397 phosphorylation level at 10 to 20 uM incubated for 48 hrs by immunoblot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 15. | ALA4775617 | B | Inhibition of Sialyltransferase in human MDA-MB-231 cells assessed as reduction in FAK Tyr576/577 phosphorylation level at 10 to 20 uM incubated for 48 hrs by immunoblot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 16. | ALA4775618 | B | Inhibition of Sialyltransferase in human MDA-MB-231 cells assessed as reduction in FAK Tyr925 phosphorylation level at 10 to 20 uM incubated for 48 hrs by immunoblot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 17. | ALA4775619 | B | Inhibition of Sialyltransferase in human MDA-MB-231 cells assessed as reduction in paxillin Tyr118 phosphorylation level at 10 to 20 uM incubated for 48 hrs by immunoblot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 18. | ALA4775620 | B | Inhibition of Sialyltransferase in human MDA-MB-231 cells assessed as reduction in IKKalpha/beta Ser176/180 phosphorylation level at 10 to 20 uM incubated for 48 hrs by immunoblot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 19. | ALA4775621 | B | Inhibition of Sialyltransferase in human MDA-MB-231 cells assessed as reduction in IkappaB-alpha Ser32 phosphorylation level at 10 to 20 uM incubated for 48 hrs by immunoblot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 20. | ALA4775622 | B | Inhibition of Sialyltransferase in human MDA-MB-231 cells assessed as reduction in NFkappaB Ser536 phosphorylation level at 10 to 20 uM incubated for 48 hrs by immunoblot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature |
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