# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4682087 | Binding | Activation of human GABAB1/GABAB2 expressed in HEK293 cells co-transfected with rat CaV2.2 channel assessed as reduction in CaV2.2-mediated peak-current amplitude in response to the depolarizing pulse by whole cell patch clamp assay | Homo sapiens | 9 | ALA4680110 | cell-based format | Scientific Literature | |
2. | ALA4682091 | Functional | Analgesic activity in Sprague-Dawley rat model of PNL injury-induced neuropathic pain assessed as pain threshold elevation percentage at 15 nmol/kg, IM administered as single dose measured after 2 to 2.5 hrs post dose | Rattus norvegicus | 8 | ALA4680110 | organism-based format | Scientific Literature | |
3. | ALA4682094 | Binding | Inhibition of rat alpha9alpha10 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at -80 mV holding potential preincubated for 5 mins followed by Ach stimulation by two electrode voltage-clamp assay | Rattus norvegicus | 8 | ALA4680110 | cell-based format | Scientific Literature | |
4. | ALA4682104 | Binding | Selectivity index, ratio of IC50 for inhibition of rat alpha9alpha10 nAChR expressed in Xenopus laevis oocytes to IC50 for activation of human GABAB1/GABAB2 expressed in HEK293 cells co-transfected with rat CaV2.2 channel assessed as reduction in CaV2.2-mediated peak Ba2+ current amplitude | 5 | ALA4680110 | cell-based format | Scientific Literature |