# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4771737 | B | Inhibition of transport activity of human GLUT5 expressed in hexose transporter deficient VW4000 yeast cells assessed as reduction in transporter-mediated [14C]-fructose uptake into cells at 100 uM measured after 10 mins by scintillation counting method | Homo sapiens | 23 | ALA4765368 | cell-based format | Scientific Literature | |
2. | ALA4771738 | B | Inhibition of transport activity of human GLUT1 expressed in hexose transporter deficient VW4000fgy1 yeast cells assessed as reduction in transporter-mediated [14C]-hexose uptake into cells at 100 uM measured after 10 mins by scintillation counting method relative to control | Homo sapiens | 3 | ALA4765368 | cell-based format | Scientific Literature | |
3. | ALA4771739 | B | Inhibition of transport activity of human GLUT4 expressed in hexose transporter deficient W4000fgy1 erg4 yeast cells assessed as reduction in transporter-mediated [14C]-hexose uptake into cells at 100 uM measured after 10 mins by scintillation counting method relative to control | Homo sapiens | 3 | ALA4765368 | cell-based format | Scientific Literature | |
4. | ALA4771740 | B | Inhibition of transport activity of human GLUT1 expressed in hexose transporter deficient VW4000fgy1 yeast cells assessed as reduction in transporter-mediated [14C]-hexose uptake into cells measured after 10 mins by scintillation counting method | Homo sapiens | 3 | ALA4765368 | cell-based format | Scientific Literature | |
5. | ALA4771741 | B | Inhibition of transport activity of human GLUT4 expressed in hexose transporter deficient W4000fgy1 erg4 yeast cells assessed as reduction in transporter-mediated [14C]-hexose uptake into cells measured after 10 mins by scintillation counting method | Homo sapiens | 3 | ALA4765368 | cell-based format | Scientific Literature | |
6. | ALA4771742 | B | Selectivity ratio of IC50 for inhibition of transport activity of human GLUT4 expressed in hexose transporter deficient W4000fgy1 erg4 yeast cells to IC50 for inhibition of transport activity of human GLUT1 expressed in hexose transporter deficient VW4000fgy1 yeast cells | Homo sapiens | 1 | ALA4765368 | cell-based format | Scientific Literature | |
7. | ALA4771743 | B | Inhibition of transport activity of human GLUT1 expressed in hexose transporter deficient VW4000fgy1 yeast cells assessed as reduction in transporter-mediated [14C]-hexose uptake into cells by measuring relative activity at 100 uM measured after 10 mins by scintillation counting method relative to control | Homo sapiens | 1 | ALA4765368 | cell-based format | Scientific Literature | |
8. | ALA4771744 | F | Cytotoxicity against human CCRF-CEM cells assessed as reduction in cell viability measured after 48 hrs by Hoechst 33342/propidium iodide staining based imaging analysis | Homo sapiens | 7 | ALA4765368 | cell-based format | Scientific Literature | |
9. | ALA4771745 | F | Cytotoxicity against human K562 cells assessed as reduction in cell viability measured after 48 hrs by Hoechst 33342/propidium iodide staining based imaging analysis | Homo sapiens | 7 | ALA4765368 | cell-based format | Scientific Literature | |
10. | ALA4771746 | F | Cytotoxicity against human KCL-22 cells assessed as reduction in cell viability measured after 48 hrs by Hoechst 33342/propidium iodide staining based imaging analysis | Homo sapiens | 7 | ALA4765368 | cell-based format | Scientific Literature | |
11. | ALA4771747 | F | Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability measured after 48 hrs by Hoechst 33342/propidium iodide staining based imaging analysis | Homo sapiens | 7 | ALA4765368 | cell-based format | Scientific Literature | |
12. | ALA4771748 | A | Cytotoxicity against human HS27 cells assessed as reduction in cell viability measured after 48 hrs by Hoechst 33342/propidium iodide staining based imaging analysis | Homo sapiens | 7 | ALA4765368 | cell-based format | Scientific Literature | |
13. | ALA4771749 | A | Cytotoxicity against human HS27 cells assessed as cell death at 100 uM measured after 48 hrs by Hoechst 33342/propidium iodide staining based imaging analysis relative to control | Homo sapiens | 1 | ALA4765368 | cell-based format | Scientific Literature | |
14. | ALA4771750 | U | Selectivity index, ratio of CC50 for human HS27 cells to CC50 for human CCRF-CEM cells | Homo sapiens | 2 | ALA4765368 | assay format | Scientific Literature | |
15. | ALA4771751 | B | Inhibition of recombinant human His6/SUMO-tagged HDAC8 expressed in Escherichia coli (BL21) DE3 pLysS assessed as residual activity at 50 uM using Boc-Lys(trifluoroacetyl)-AMC as substrate preincubated for 60 mins followed by substrate addition and measured after 60 mins by fluorescence assay relative to control | Homo sapiens | 24 | ALA4765368 | assay format | Scientific Literature | |
16. | ALA4771753 | B | Inhibition of recombinant human N-terminal GST-tagged HDAC4 (627 to end residues) expressed in baculovirus infected Sf9 insect cells assessed as residual activity at 50 uM using Boc-Lys(trifluoroacetyl)-AMC as substrate preincubated for 60 mins followed by substrate addition and measured after 60 mins by fluorescence assay relative to control | Homo sapiens | 24 | ALA4765368 | cell-based format | Scientific Literature |