| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4685761 | B | Protac activity at CRBN/BCL-XL in human MOLT-4 cells assessed as induction of BCL-XL degradation measured after 16 hrs by immunoblotting analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 2. | ALA4685762 | F | Antiproliferative activity against human MOLT-4 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay | Homo sapiens | 56 | cell-based format | Scientific Literature | ||
| 3. | ALA4685765 | B | Protac activity at CRBN/BCL-XL in human MOLT-4 cells assessed as induction of BCL-XL degradation by measuring remaining BCL-XL level at 50 nM measured after 16 hrs by immunoblotting analysis relative to control | Homo sapiens | 30 | cell-based format | Scientific Literature | ||
| 4. | ALA4685766 | B | Protac activity at CRBN/BCL2 in human MOLT-4 cells assessed as induction of BCL2 degradation at 50 nM measured after 16 hrs by immunoblotting analysis | Homo sapiens | 30 | cell-based format | Scientific Literature | ||
| 5. | ALA4685767 | F | Potency index, ratio of ABT-263 IC50 to test compound IC50 for antiproliferative activity against human MOLT-4 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 6. | ALA4685768 | F | Antiproliferative activity against human RS4-11 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 7. | ALA4685769 | F | Antiproliferative activity against human NCI-H146 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 8. | ALA4685770 | T | Toxicity in human platelet assessed as reduction in cell viability measured after 48 hrs by MTS assay | Homo sapiens | 8 | tissue-based format | Scientific Literature | ||
| 9. | ALA4685771 | U | Selectivity index, ratio of IC50 for human platelet to IC50 for human MOLT-4 cells | Homo sapiens | 8 | assay format | Scientific Literature | ||
| 10. | ALA4685772 | B | Protac activity at CRBN/BCL-XL in human MOLT-4 cells assessed as induction of BCL-XL degradation at 100 nM measured within 2 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4685773 | B | Protac activity at CRBN/BCL-XL in human MOLT-4 cells assessed as induction of BCL-XL degradation at 100 nM measured after 8 hrs by immunoblotting analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4685774 | B | Protac activity at CRBN/BCL-XL in human MOLT-4 cells assessed as induction of BCL-XL degradation at 100 nM preincubated for 16 hrs followed by compound washout by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4685775 | B | Protac activity at CRBN/BCL-XL in human MOLT-4 cells assessed as induction of BCL-XL degradation at 10 to 100 nM measured after 16 hrs in presence of competitive CRBN ligand pomalidomide by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4685776 | B | Protac activity at CRBN/BCL-XL in human MOLT-4 cells assessed as induction of BCL-XL degradation at 3.7 to 300 nM measured after 16 hrs in presence of proteasome inhibitor MG-132 by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4685778 | B | Protac activity at CRBN/BCL-XL in human platelet assessed as induction of BCL-XL degradation up to 1 uM measured after 16 hrs by immunoblotting analysis | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 16. | ALA4685779 | F | Ratio of IC50 for human MOLT-4 cells in presence of pomalidomide to IC50 for human MOLT-4 cells | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 17. | ALA4685780 | F | Induction of apoptosis in human MOLT-4 cells assessed as increase in cleaved PARP expression measured after 16 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA4685781 | F | Induction of apoptosis in human MOLT-4 cells assessed as increase in cleaved caspase-3 expression measured after 16 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA4685782 | F | Induction of apoptosis in human MOLT-4 cells assessed as viable cells at 10 nM measured after 48 hrs by Alexa Fluor 647-Annexin V/propidium iodide staining based flow cytometry (Rvb = 97.1 to 97.3%) | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 20. | ALA4685783 | F | Induction of apoptosis in human MOLT-4 cells assessed as early apoptotic cells at 10 nM measured after 48 hrs by Alexa Fluor 647-Annexin V/propidium iodide staining based flow cytometry (Rvb = 1.5 to 1.7%) | Homo sapiens | 2 | cell-based format | Scientific Literature |
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