| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4772592 | B | Inverse agonist activity at human RORgammat assessed as inhibition of N-terminal biotinylated co-activator SRC1 recruitment measured after 60 mins by FRET assay | Homo sapiens | 38 | ALA4765390 | single protein format | Scientific Literature | |
| 2. | ALA4772593 | B | Inverse agonist activity at human RORgammat assessed as maximal inhibition of N-terminal biotinylated co-activator SRC1 recruitment measured after 60 mins by FRET assay relative to agonist | Homo sapiens | 38 | ALA4765390 | single protein format | Scientific Literature | |
| 3. | ALA4772594 | P | Aqueous kinetic solubility of the compound at pH 7.4 PBS buffer at 100 uM incubated for 120 mins by LC-MS/MS analysis | 2 | ALA4765390 | small-molecule physicochemical format | Scientific Literature | ||
| 4. | ALA4772595 | B | Inverse agonist activity at RORgammat in mouse CD4+ T cells assessed as inhibition of differentiation into Th17 cells by measuring IL-17 production at 0.3 uM by flow cytometry relative to control | Mus musculus | 2 | ALA4765390 | cell-based format | Scientific Literature | |
| 5. | ALA4772596 | B | Inverse agonist activity at ROR-alpha (unknown origin) expressed in HEK293 cells by Gal4-luciferase reporter assay | Homo sapiens | 1 | ALA4765390 | cell-based format | Scientific Literature | |
| 6. | ALA4772597 | B | Inverse agonist activity at ROR-beta (unknown origin) expressed in HEK293 cells by Gal4-luciferase reporter assay | Homo sapiens | 1 | ALA4765390 | cell-based format | Scientific Literature | |
| 7. | ALA4772598 | B | Inverse agonist activity at human ROR-gammat LBD expressed in HEK293T cells assessed as inhibition of RORgammat transcription by Gal4-luciferase reporter assay | Homo sapiens | 1 | ALA4765390 | cell-based format | Scientific Literature | |
| 8. | ALA4772599 | A | Tmax in CD-1 mouse at 5 mg/kg, po administered as single dose measured after 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | ALA4765390 | organism-based format | Scientific Literature | |
| 9. | ALA4772600 | A | Cmax in CD-1 mouse at 1 mg/kg, iv administered as single dose measured after 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | ALA4765390 | organism-based format | Scientific Literature | |
| 10. | ALA4772601 | A | Cmax in CD-1 mouse at 5 mg/kg, po administered as single dose measured after 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | ALA4765390 | organism-based format | Scientific Literature | |
| 11. | ALA4772602 | A | AUC (0 to last) in CD-1 mouse at 1 mg/kg, iv administered as single dose measured after 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | ALA4765390 | organism-based format | Scientific Literature | |
| 12. | ALA4772603 | A | AUC (0 to last) in CD-1 mouse at 5 mg/kg, po administered as single dose measured after 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | ALA4765390 | organism-based format | Scientific Literature | |
| 13. | ALA4772604 | A | Volume of distribution at steady state in CD-1 mouse at 1 mg/kg, iv administered as single dose measured after 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | ALA4765390 | organism-based format | Scientific Literature | |
| 14. | ALA4772605 | A | Half life in CD-1 mouse at 1 mg/kg, iv administered as single dose measured after 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | ALA4765390 | organism-based format | Scientific Literature | |
| 15. | ALA4772606 | A | Half life in CD-1 mouse at 5 mg/kg, po administered as single dose measured after 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | ALA4765390 | organism-based format | Scientific Literature | |
| 16. | ALA4772607 | A | Clearance in CD-1 mouse at 1 mg/kg, iv administered as single dose measured after 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | ALA4765390 | organism-based format | Scientific Literature | |
| 17. | ALA4772608 | A | Oral bioavailability in CD-1 mouse at 5 mg/kg administered as single dose measured after 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | ALA4765390 | organism-based format | Scientific Literature | |
| 18. | ALA4772609 | F | Protection against imiquimod-induced psoriasis in BALB/c mouse model assessed as reduction of skin scaling at 25 mg/kg, po dosed twice daily relative to control | Mus musculus | 1 | ALA4765390 | organism-based format | Scientific Literature | |
| 19. | ALA4772610 | F | Protection against imiquimod-induced psoriasis in BALB/c mouse model assessed as reduction in ear erythema at 25 mg/kg, po dosed twice daily relative to control | Mus musculus | 1 | ALA4765390 | organism-based format | Scientific Literature | |
| 20. | ALA4772611 | F | Protection against imiquimod-induced psoriasis in BALB/c mouse model assessed as reduction in back skin erythema at 25 mg/kg, po dosed twice daily relative to control | Mus musculus | 1 | ALA4765390 | organism-based format | Scientific Literature |
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