# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4677392 | B | Binding affinity to signal peptide of human CD4-YFP expressed in CHO-K1 cells assessed down-modulation of CD4 surface expression incubated for 24 hrs by flow cytometry | Homo sapiens | 15 | ALA4673284 | cell-based format | Scientific Literature | |
2. | ALA4677393 | F | Antiviral activity against HIV-1 NL4-3 infected in human MT-4 cells assessed as inhibition of viral replication by measuring inhibition of cell viability preincubated with cells for 15 mins followed by viral infection and measured after 4 days by MTS/PES assay | Human immunodeficiency virus 1 | 15 | ALA4673284 | organism-based format | Scientific Literature | |
3. | ALA4677394 | A | Cytotoxicity against human MT-4 cells assessed as inhibition of cell viability incubated for 48 hrs by MTS/PES assay | Homo sapiens | 15 | ALA4673284 | cell-based format | Scientific Literature | |
4. | ALA4677395 | T | Therapeutic index, ratio of CC50 for human MT-4 cells to IC50 for human CD4-YFP expressed in CHO-K1 cells assessed down-modulation of CD4 surface expression incubated for 24 hrs by flow cytometry | 2 | ALA4673284 | cell-based format | Scientific Literature | ||
5. | ALA4677396 | P | Thermodynamic solubility of the compound in aqueous PBS buffer at pH 7.4 incubated for 72 hrs by shake flask method based UV-Vis absorption spectroscopy | 6 | ALA4673284 | small-molecule physicochemical format | Scientific Literature |