# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4732558 | B | Inhibition of recombinant human PDE-4B expressed in Escherichia coli at 20 uM using cAMP as substrate incubated for 60 mins by PDE4 assay kit method relative to control | Homo sapiens | 29 | assay format | Scientific Literature | ||
2. | ALA4732559 | B | Inhibition of recombinant human PDE-4B expressed in Escherichia coli using cAMP as substrate incubated for 60 mins by PDE4 assay kit method | Homo sapiens | 1 | assay format | Scientific Literature | ||
3. | ALA4732560 | P | Lipophilicity, logP of compound | 1 | small-molecule physicochemical format | Scientific Literature | |||
4. | ALA4732566 | F | Antiinflammatory activity against human PBMC derived primary macrophages assessed as reduction in LPS-induced cell morphology changes at 50 uM incubated for 24 hrs by scanning electron microscopic analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
5. | ALA4732568 | A | Cytotoxicity against human PBMC derived primary macrophages assessed as reduction in cell viability at 5 to 50 uM incubated for 24 hrs by LDH assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
6. | ALA4732570 | F | Antiinflammatory activity against human PBMC derived primary macrophages assessed as reduction in LPS-induced IL-8 level at 20 uM incubated for 24 hrs by ELISA relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
7. | ALA4732571 | F | Antiinflammatory activity against human PBMC derived primary macrophages assessed as reduction in LPS-induced IL-8 level at 50 uM incubated for 24 hrs by ELISA relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
8. | ALA4732572 | F | Antiinflammatory activity against human PBMC derived primary macrophages assessed as reduction in LPS-induced IL-1beta level at 20 uM incubated for 24 hrs by ELISA relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
9. | ALA4732573 | F | Antiinflammatory activity against human PBMC derived primary macrophages assessed as reduction in LPS-induced IL-1beta level at 50 uM incubated for 24 hrs by ELISA relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
10. | ALA4732574 | F | Antiinflammatory activity against human PBMC derived primary macrophages assessed as reduction in LPS-induced TNF-alpha level at 50 uM incubated for 24 hrs by ELISA relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
11. | ALA4732575 | F | Antiinflammatory activity against human PBMC derived primary macrophages assessed as reduction in LPS-induced TNF-alpha level at 5 uM incubated for 24 hrs by ELISA relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
12. | ALA4732576 | F | Antiinflammatory activity against human PBMC derived primary macrophages assessed as reduction in LPS-induced IL-6 level at 50 uM incubated for 24 hrs by ELISA relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
13. | ALA4732577 | F | Antiinflammatory activity against human PBMC derived primary macrophages assessed as reduction in LPS-induced IL-6 level at 20 uM incubated for 24 hrs by ELISA relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
14. | ALA4732578 | F | Antiinflammatory activity against human PBMC derived primary macrophages assessed as reduction in LPS-induced IL-6 level at 10 uM incubated for 24 hrs by ELISA relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
15. | ALA4732579 | F | Antiinflammatory activity against human PBMC derived primary macrophages assessed as reduction in LPS-induced IL-6 level at 5 uM incubated for 24 hrs by ELISA relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
16. | ALA4732585 | F | Antiinflammatory activity in BALB/cJRj mouse air pouch model assessed as decrease in LPS-stimulated monocyte recruitment in air pouch at 200 uM, sc measured after 6 hrs by flow cytometry analysis relative to control | Mus musculus | 1 | organism-based format | Scientific Literature | ||
17. | ALA4732587 | F | Antiinflammatory activity in BALB/cJRj mouse air pouch model assessed as decrease in LPS-stimulated macrophage recruitment in air pouch at 2 to 20 uM, sc measured after 6 hrs by flow cytometry analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
18. | ALA4732588 | F | Antiinflammatory activity in BALB/cJRj mouse air pouch model assessed as decrease in LPS-stimulated monocyte recruitment in air pouch at 2 to 20 uM, sc measured after 6 hrs by flow cytometry analysis | Mus musculus | 1 | organism-based format | Scientific Literature |