| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4766269 | B | Agonist activity at GPR40 in Sprague-Dawley rat pancreatic islets assessed as induction of glucose-mediated insulin secretion measured after 90 mins in EBSS buffer by ELISA | Rattus norvegicus | 9 | ALA4765234 | tissue-based format | Scientific Literature | |
| 2. | ALA4766270 | B | Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillation counting method | Homo sapiens | 32 | ALA4765234 | cell membrane format | Scientific Literature | |
| 3. | ALA4766271 | F | Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay | Homo sapiens | 31 | ALA4765234 | cell-based format | Scientific Literature | |
| 4. | ALA4766272 | F | Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measured over 3 mins by calcium 4 dye based FLIPR assay relative to 100 uM linoleic acid | Homo sapiens | 31 | ALA4765234 | cell-based format | Scientific Literature | |
| 5. | ALA4766273 | B | Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay | Homo sapiens | 32 | ALA4765234 | cell-based format | Scientific Literature | |
| 6. | ALA4766274 | B | Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay relative to control | Homo sapiens | 32 | ALA4765234 | cell-based format | Scientific Literature | |
| 7. | ALA4766275 | B | Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay | Mus musculus | 32 | ALA4765234 | cell-based format | Scientific Literature | |
| 8. | ALA4766276 | B | Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay relative to control | Mus musculus | 32 | ALA4765234 | cell-based format | Scientific Literature | |
| 9. | ALA4766277 | B | Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay | Rattus norvegicus | 32 | ALA4765234 | cell-based format | Scientific Literature | |
| 10. | ALA4766278 | B | Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay relative to control | Rattus norvegicus | 32 | ALA4765234 | cell-based format | Scientific Literature | |
| 11. | ALA4766279 | F | Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay | Homo sapiens | 31 | ALA4765234 | cell-based format | Scientific Literature | |
| 12. | ALA4766280 | F | Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation in presence of terbium cryptate-labeled anti IP1/d2-labelled IP1 measured after 120 mins by HTRF assay relative to AMG837 | Homo sapiens | 31 | ALA4765234 | cell-based format | Scientific Literature | |
| 13. | ALA4766281 | B | Displacement of [3H]-(S)-2-(6-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid from human recombinant full-length GPR40 expressed in human HEK293 cell membrane assessed as dissociation constant measured after 2 hrs by radioligand competitive assay | Homo sapiens | 9 | ALA4765234 | cell membrane format | Scientific Literature | |
| 14. | ALA4766282 | B | Displacement of [3H]-(S)-2-(6-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid from human recombinant full-length GPR40 expressed in human HEK293 cell membrane assessed as residence time by radioligand competitive assay | Homo sapiens | 9 | ALA4765234 | cell membrane format | Scientific Literature | |
| 15. | ALA4766283 | B | Agonist activity at GPR40 in mouse MIN6 cells assessed as induction of glucose-mediated insulin secretion incubated for 2 hrs by ELISA | Mus musculus | 9 | ALA4765234 | cell-based format | Scientific Literature | |
| 16. | ALA4766284 | F | Hypoglycemic activity in Balb/c mouse assessed as effective dose causing reduction in blood glucose level administered orally 60 mins prior to glucose challenge measured for 60 mins by IPGTT | Mus musculus | 10 | ALA4765234 | organism-based format | Scientific Literature | |
| 17. | ALA4766286 | B | Inhibition of human ERG | Homo sapiens | 4 | ALA4765234 | single protein format | Scientific Literature | |
| 18. | ALA4766290 | A | Drug metabolism in human hepatocytes assessed as glucuronidation by LC-MS/MS analysis | Homo sapiens | 2 | ALA4765234 | cell-based format | Scientific Literature | |
| 19. | ALA4766291 | A | Drug metabolism in rat hepatocytes assessed as glucuronidation by LC-MS/MS analysis | Rattus norvegicus | 4 | ALA4765234 | cell-based format | Scientific Literature | |
| 20. | ALA4766292 | A | Drug metabolism in dog hepatocytes assessed as glucuronidation by LC-MS/MS analysis | Canis lupus familiaris | 4 | ALA4765234 | cell-based format | Scientific Literature |
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