# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4709778 | Functional | Effect on IDO1 expression in IFN-gamma-stimulated human HeLa cells incubated for 24 hrs by western blot analysis | Homo sapiens | 1 | ALA4706547 | tissue-based format | Scientific Literature | |
2. | ALA4709779 | Functional | Effect on TDO expression in human A 172 cells incubated for 24 hrs by western blot analysis | Homo sapiens | 1 | ALA4706547 | cell-based format | Scientific Literature | |
3. | ALA4709780 | Binding | Inhibition of IDO1 (unknown origin) assessed as reduction in L-kynurenine formation using L-tryptophan as substrate incubated for 30 mins by microplate spectrophotometry analysis | Homo sapiens | 38 | ALA4706547 | single protein format | Scientific Literature | |
4. | ALA4709781 | Binding | Inhibition of TDO (unknown origin) assessed as reduction in L-kynurenine formation using L-tryptophan as substrate incubated for 30 mins microplate spectrophotometry analysis | Homo sapiens | 38 | ALA4706547 | single protein format | Scientific Literature | |
5. | ALA4709782 | Functional | Antioxidant activity assessed as DPPH radical scavenging activity at 5 to 160 uM measured after 30 mins | 1 | ALA4706547 | assay format | Scientific Literature | ||
6. | ALA4709783 | Physicochemical | Redox activity of compound assessed as increase in H2O2 production at > 50 uM incubated for 15 mins by HRP-PR staining based fluorometric analysis relative to control | 1 | ALA4706547 | small-molecule physicochemical format | Scientific Literature | ||
7. | ALA4709784 | Physicochemical | Redox activity of compound assessed as increase in H2O2 production incubated for 15 mins by HRP-PR staining based fluorometric analysis | 1 | ALA4706547 | small-molecule physicochemical format | Scientific Literature | ||
8. | ALA4709785 | Binding | Metal chelating activity assessed as phenanthridazine-Fe2+ complex formation incubated for 5 mins by photometric analysis | 1 | ALA4706547 | assay format | Scientific Literature | ||
9. | ALA4709786 | Binding | Inhibition of human IDO1 assessed as effect on reactive cysteine residue of IDO1 at 10 uM incubated for 30 mins by MPB-labelling based Western blot analysis | Homo sapiens | 1 | ALA4706547 | single protein format | Scientific Literature | |
10. | ALA4709787 | Binding | Inhibition of human TDO assessed as effect on reactive cysteine residue of IDO1 at 10 uM incubated for 30 mins by MPB-labelling based Western blot analysis | Homo sapiens | 1 | ALA4706547 | single protein format | Scientific Literature | |
11. | ALA4709788 | Binding | Binding affinity to METTL3 (unknown origin) | Homo sapiens | 1 | ALA4706547 | single protein format | Scientific Literature | |
12. | ALA4709789 | Binding | Binding affinity to JMJD6 (unknown origin) | Homo sapiens | 1 | ALA4706547 | single protein format | Scientific Literature | |
13. | ALA4709790 | Binding | Binding affinity to NSUN2 (unknown origin) | Homo sapiens | 1 | ALA4706547 | single protein format | Scientific Literature | |
14. | ALA4709791 | Binding | Binding affinity to HAT1 (unknown origin) | Homo sapiens | 1 | ALA4706547 | single protein format | Scientific Literature | |
15. | ALA4709792 | Binding | Inhibition of IDO1 in IFN-gamma-induced human HeLa cells assessed as reduction in L-kynurenine formation using L-tryptophan as substrate incubated for 24 hrs | Homo sapiens | 1 | ALA4706547 | tissue-based format | Scientific Literature | |
16. | ALA4709793 | Binding | Inhibition of TDO in human A 172 cells assessed as reduction in L-kynurenine formation using L-tryptophan as substrate incubated for 24 hrs | Homo sapiens | 1 | ALA4706547 | cell-based format | Scientific Literature | |
17. | ALA4709794 | Functional | Cytotoxicity against human HeLa cells assessed as reduction in cell viability at 0.1 to 10 uM incubated for 24 hrs by MTT assay | Homo sapiens | 1 | ALA4706547 | cell-based format | Scientific Literature | |
18. | ALA4709795 | Functional | Cytotoxicity against human A 172 cells assessed as reduction in cell viability at 0.1 to 10 uM incubated for 24 hrs by MTT assay | Homo sapiens | 1 | ALA4706547 | cell-based format | Scientific Literature | |
19. | ALA4709796 | Functional | Antitumor activity against human LL2 cells allografted in C57BL/6 mouse assessed as tumor growth inhibition at 30 mg/kg, ip administered for 11 days and measured upto 20 days relative to control | Homo sapiens | 2 | ALA4706547 | organism-based format | Scientific Literature | |
20. | ALA4709797 | Functional | Antitumor activity against human Hepa1-6 cells allografted in C57BL/6 mouse assessed as tumor growth inhibition at 30 mg/kg, ip administered for 11 days and measured upto 20 days relative to control | Homo sapiens | 2 | ALA4706547 | organism-based format | Scientific Literature |