| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4770559 | T | Toxicity in BALB/c nude mouse xenografted with human MV4-11 cells assessed as body weight loss at 40 mg/kg, iv administered once daily for 21 days and measured 2 or 3 times per week | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 2. | ALA4770560 | F | Antitumor activity against human MV4-11 cells xenografted in Balb/c nude mouse assessed as reduction in tumor volume at 40 mg/kg, iv administered once daily for 21 days (Rvb = 1.00 g) | Homo sapiens | 2 | organism-based format | Scientific Literature | ||
| 3. | ALA4770561 | B | Inhibition of CDK9 in human MV4-11 cells assessed as reduction in RNA Polymerase 2 CTD phosphorylation at Ser2 residues incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA4770562 | B | Inhibition of CDK9/Cyclin T1 (unknown origin) preincubated for 20 mins followed by ATP addition and measured after 120 mins in presence of [33P-gamma] ATP by hotspot kinase assay | Homo sapiens | 34 | protein complex format | Scientific Literature | ||
| 5. | ALA4770564 | B | Inhibition of CDK2/Cyclin A (unknown origin) preincubated for 20 mins followed by ATP addition and measured after 120 mins in presence of [33P-gamma] ATP by hotspot kinase assay | Homo sapiens | 27 | protein complex format | Scientific Literature | ||
| 6. | ALA4770566 | B | Selectivity index, ratio of IC50 for CDK2/Cyclin A (unknown origin) to IC50 for CDK9/Cyclin T1 (unknown origin) | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 7. | ALA4770568 | B | Inhibition of CDK7/Cyclin H (unknown origin) preincubated for 20 mins followed by ATP addition and measured after 120 mins in presence of [33P-gamma] ATP by hotspot kinase assay | Homo sapiens | 2 | protein complex format | Scientific Literature | ||
| 8. | ALA4770569 | F | Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 72 hrs by Celltiter-Glo luminescent assay | Homo sapiens | 39 | cell-based format | Scientific Literature | ||
| 9. | ALA4770570 | B | Inhibition of CDK1/Cyclin B (unknown origin) preincubated for 20 mins followed by ATP addition and measured after 120 mins in presence of [33P-gamma] ATP by hotspot kinase assay | Homo sapiens | 1 | protein complex format | Scientific Literature | ||
| 10. | ALA4770571 | B | Inhibition of CDK2/Cyclin E (unknown origin) preincubated for 20 mins followed by ATP addition and measured after 120 mins in presence of [33P-gamma] ATP by hotspot kinase assay | Homo sapiens | 1 | protein complex format | Scientific Literature | ||
| 11. | ALA4770572 | B | Inhibition of CDK3/Cyclin E (unknown origin) preincubated for 20 mins followed by ATP addition and measured after 120 mins in presence of [33P-gamma] ATP by hotspot kinase assay | Homo sapiens | 1 | protein complex format | Scientific Literature | ||
| 12. | ALA4770573 | B | Inhibition of CDK4/Cyclin D1 (unknown origin) preincubated for 20 mins followed by ATP addition and measured after 120 mins in presence of [33P-gamma] ATP by hotspot kinase assay | Homo sapiens | 1 | protein complex format | Scientific Literature | ||
| 13. | ALA4770574 | B | Inhibition of CDK5/p25 (unknown origin) preincubated for 20 mins followed by ATP addition and measured after 120 mins in presence of [33P-gamma] ATP by hotspot kinase assay | Homo sapiens | 1 | protein complex format | Scientific Literature | ||
| 14. | ALA4770575 | B | Inhibition of CDK6/Cyclin D3 (unknown origin) preincubated for 20 mins followed by ATP addition and measured after 120 mins in presence of [33P-gamma] ATP by hotspot kinase assay | Homo sapiens | 1 | protein complex format | Scientific Literature | ||
| 15. | ALA4770576 | B | Inhibition of CDK8/Cyclin C (unknown origin) preincubated for 20 mins followed by ATP addition and measured after 120 mins in presence of [33P-gamma] ATP by hotspot kinase assay | Homo sapiens | 1 | protein complex format | Scientific Literature | ||
| 16. | ALA4770577 | B | Inhibition of CDK19/Cyclin C (unknown origin) preincubated for 20 mins followed by ATP addition and measured after 120 mins in presence of [33P-gamma] ATP by hotspot kinase assay | Homo sapiens | 1 | protein complex format | Scientific Literature | ||
| 17. | ALA4770578 | B | Selectivity index, ratio of IC50 for CDK1/Cyclin B (unknown origin) to IC50 for CDK9/Cyclin T1 (unknown origin) | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 18. | ALA4770579 | B | Selectivity index, ratio of IC50 for CDK2/Cyclin E (unknown origin) to IC50 for CDK9/Cyclin T1 (unknown origin) | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 19. | ALA4770580 | B | Selectivity index, ratio of IC50 for CDK3/Cyclin E (unknown origin) to IC50 for CDK9/Cyclin T1 (unknown origin) | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 20. | ALA4770581 | B | Selectivity index, ratio of IC50 for CDK4/Cyclin D1 (unknown origin) to IC50 for CDK9/Cyclin T1 (unknown origin) | Homo sapiens | 1 | assay format | Scientific Literature |
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