| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4733961 | B | Inhibition of NAE (unknown origin)-mediated neddylation assessed as suppression of cullin1-Nedd8 adduct formation at 25 uM preincubated for 10 mins followed by ATP addition and measured after 30 mins by immunoblot analysis relative to control | Homo sapiens | 44 | ALA4732082 | single protein format | Scientific Literature | |
| 2. | ALA4733962 | F | Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation at 100 uM incubated for 48 hrs by CCK-8 assay relative to control | Homo sapiens | 44 | ALA4732082 | cell-based format | Scientific Literature | |
| 3. | ALA4733963 | B | Inhibition of NAE (unknown origin)-mediated neddylation assessed as suppression of cullin1-Nedd8 adduct formation preincubated for 10 mins followed by ATP addition and measured after 30 mins by immunoblot analysis | Homo sapiens | 5 | ALA4732082 | single protein format | Scientific Literature | |
| 4. | ALA4733964 | F | Antiproliferative activity against human A549 cells incubated for 48 hrs by CCK-8 assay | Homo sapiens | 5 | ALA4732082 | cell-based format | Scientific Literature | |
| 5. | ALA4733965 | F | Antiproliferative activity against human H1299 cells incubated for 48 hrs by CCK-8 assay | Homo sapiens | 5 | ALA4732082 | cell-based format | Scientific Literature | |
| 6. | ALA4733966 | A | Cytotoxicity against human 16H6E cells incubated for 48 hrs by CCK-8 assay | Homo sapiens | 5 | ALA4732082 | cell-based format | Scientific Literature | |
| 7. | ALA4733967 | A | Cytotoxicity against human BEAS-2B cells incubated for 48 hrs by CCK-8 assay | Homo sapiens | 5 | ALA4732082 | cell-based format | Scientific Literature | |
| 8. | ALA4733968 | B | Inhibition of NAE-mediated neddylation in human A549 cells assessed as suppression of cullin1-Nedd8 adduct formation at 12.5 to 25 uM measured after 6 to 12 hrs by Western blot analysis | Homo sapiens | 1 | ALA4732082 | cell-based format | Scientific Literature | |
| 9. | ALA4733969 | B | Inhibition of NAE-mediated neddylation in human A549 cells assessed as suppression of cullin2-Nedd8 adduct formation at 12.5 to 25 uM measured after 6 to 12 hrs by Western blot analysis | Homo sapiens | 1 | ALA4732082 | cell-based format | Scientific Literature | |
| 10. | ALA4733970 | B | Inhibition of NAE-mediated neddylation in human A549 cells assessed as suppression of cullin4a-Nedd8 adduct formation at 12.5 to 25 uM measured after 6 to 12 hrs by Western blot analysis | Homo sapiens | 1 | ALA4732082 | cell-based format | Scientific Literature | |
| 11. | ALA4733971 | B | Inhibition of NAE-mediated neddylation in human A549 cells assessed as suppression of cullin5-Nedd8 adduct formation at 12.5 to 25 uM measured after 6 to 12 hrs by Western blot analysis | Homo sapiens | 1 | ALA4732082 | cell-based format | Scientific Literature | |
| 12. | ALA4733972 | B | Inhibition of NAE-mediated UBE2M neddylation in human A549 cells at 12.5 to 25 uM measured after 6 to 12 hrs by Western blot analysis | Homo sapiens | 1 | ALA4732082 | cell-based format | Scientific Literature | |
| 13. | ALA4733973 | F | Induction of Wee1 accumulation in human A549 cells at 50 uM incubated for 6 to 12 hrs by Western blot analysis | Homo sapiens | 1 | ALA4732082 | cell-based format | Scientific Literature | |
| 14. | ALA4733974 | F | Induction of p27 accumulation in human A549 cells at 50 uM incubated for 6 to 12 hrs by Western blot analysis | Homo sapiens | 1 | ALA4732082 | cell-based format | Scientific Literature | |
| 15. | ALA4733975 | F | Induction of apoptosis in human A549 cells assessed as increase in PARP cleavage at 12.5 uM by Western blot analysis | Homo sapiens | 1 | ALA4732082 | cell-based format | Scientific Literature | |
| 16. | ALA4733976 | F | Induction of apoptosis in human A549 cells assessed as increase in ratio of early and late apoptotic cells at 10 to 40 uM after 48 hrs by Annexin V-FITC/PI double staining based flow cytometric analysis (Rvb = 2.6%) | Homo sapiens | 1 | ALA4732082 | cell-based format | Scientific Literature | |
| 17. | ALA4733977 | F | Induction of cellular senescence in human A549 cells at 10 uM by SA-beta-gal-staining based assay | Homo sapiens | 1 | ALA4732082 | cell-based format | Scientific Literature | |
| 18. | ALA4733978 | F | Antitumor activity against human A549 cells xenografted in nude mouse assessed as decrease in tumor weight at 30 mg/kg, ip qd for 5 days on and 2 days off dosing and measured after 24 days post-treatment | Homo sapiens | 1 | ALA4732082 | organism-based format | Scientific Literature | |
| 19. | ALA4733979 | F | Antitumor activity against human A549 cells xenografted in nude mouse assessed as decrease in tumor volume at 30 mg/kg, ip qd for 5 days on and 2 days off dosing and measured after 24 days post-treatment | Homo sapiens | 1 | ALA4732082 | organism-based format | Scientific Literature | |
| 20. | ALA4733980 | F | Antitumor activity against human A549 cells xenografted in nude mouse assessed as inhibition of tumor growth at 60 mg/kg, po qd for 5 days on and 2 days off dosing and measured after 24 days post-treatment | Homo sapiens | 1 | ALA4732082 | organism-based format | Scientific Literature |
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