| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4737162 | B | Displacement of [125I]Tyr3-neurotensin from human recombinant NTS1 stably expressed in CHO-K1 cell membranes incubated for 60 mins by gamma counter analysis | Homo sapiens | 31 | ALA4732177 | cell membrane format | Scientific Literature | |
| 2. | ALA4737163 | B | Displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 stably expressed in human 1321N1 cell membranes incubated for 60 mins by gamma counter analysis | Homo sapiens | 31 | ALA4732177 | cell membrane format | Scientific Literature | |
| 3. | ALA4737164 | B | Selectivity index, ratio of Ki for displacement of [125I]Tyr3-neurotensin from human recombinant NTS2 to Ki for displacement of [125I]Tyr3-neurotensin from human recombinant NTS1 | 26 | ALA4732177 | assay format | Scientific Literature | ||
| 4. | ALA4737165 | A | Stability of compound in rat plasma assessed as half life at 1 mM incubated for 1 to 20 mins by UPLC-MS analysis | Rattus norvegicus | 2 | ALA4732177 | cell-free format | Scientific Literature | |
| 5. | ALA4737166 | A | Stability of compound in rat CSF assessed as half life at 1 mM incubated for 24 hrs by UPLC-MS analysis | Rattus norvegicus | 2 | ALA4732177 | tissue-based format | Scientific Literature | |
| 6. | ALA4737167 | F | Antinociceptive activity in Sprague-Dawley rat model assessed as increased in tail withdrawal latency administered intrathecally measured every 10 mins for 60 mins by radiant heat tail-flick test | Rattus norvegicus | 1 | ALA4732177 | organism-based format | Scientific Literature | |
| 7. | ALA4737168 | F | Antinociceptive activity in Sprague-Dawley rat model assessed as maximum efficacy causing increase in tail withdrawal latency administered intrathecally measured every 10 mins for 60 mins by radiant heat tail-flick test | Rattus norvegicus | 1 | ALA4732177 | organism-based format | Scientific Literature | |
| 8. | ALA4737169 | F | Antinociceptive activity in Sprague-Dawley rat model assessed as maximum possible effect at 10 microg/kg, IT measured every 10 mins for 60 mins by radiant heat tail-flick test relative to control | Rattus norvegicus | 1 | ALA4732177 | organism-based format | Scientific Literature | |
| 9. | ALA4737170 | F | Antinociceptive activity in Sprague-Dawley rat model assessed as maximum possible effect at 30 microg/kg, IT measured every 10 mins for 60 mins by radiant heat tail-flick test relative to control | Rattus norvegicus | 1 | ALA4732177 | organism-based format | Scientific Literature | |
| 10. | ALA4737171 | F | Antinociceptive activity in Sprague-Dawley rat model assessed as maximum possible effect at 60 microg/kg, IT measured every 10 mins for 60 mins by radiant heat tail-flick test relative to control | Rattus norvegicus | 1 | ALA4732177 | organism-based format | Scientific Literature | |
| 11. | ALA4737172 | F | Antinociceptive activity in Sprague-Dawley rat model assessed as maximum possible effect at 90 microg/kg, IT measured every 10 mins for 60 mins by radiant heat tail-flick test relative to control | Rattus norvegicus | 1 | ALA4732177 | organism-based format | Scientific Literature | |
| 12. | ALA4737173 | F | Antinociceptive activity in Sprague-Dawley rat model assessed as maximum possible effect at 150 microg/kg, IT measured every 10 mins for 60 mins by radiant heat tail-flick test relative to control | Rattus norvegicus | 2 | ALA4732177 | organism-based format | Scientific Literature | |
| 13. | ALA4737174 | F | Antinociceptive activity in Sprague-Dawley rat model assessed as effective dose administered intrathecally and measured every 10 mins for 60 mins by radiant heat tail-flick test | Rattus norvegicus | 1 | ALA4732177 | organism-based format | Scientific Literature | |
| 14. | ALA4737178 | F | Antinociceptive activity in Sprague-Dawley rat model of formalin-induced nociception pain assessed as reduction in pain behaviour by measuring less lifting of formalin injected hind paw during acute phase at 30 to 150 microg/kg, IT measured for 9 mins | Rattus norvegicus | 1 | ALA4732177 | organism-based format | Scientific Literature | |
| 15. | ALA4737179 | F | Antinociceptive activity in Sprague-Dawley rat model of formalin-induced nociception pain assessed as reduction in pain behaviour by measuring less lifting of formalin injected hind paw during inflammatory phase at 30 to 150 microg/kg, IT | Rattus norvegicus | 1 | ALA4732177 | organism-based format | Scientific Literature | |
| 16. | ALA4737187 | F | Antiallodynic activity in Sprague-Dawley rat model of complete Freund's adjuvant-induced chronic inflammatory pain assessed as increase in paw withdrawl threshold at 150 microg/kg, IT dosed on day 7 and 14 measured at 15 to 120 mins post dose relative to control | Rattus norvegicus | 1 | ALA4732177 | organism-based format | Scientific Literature | |
| 17. | ALA4737188 | T | Cardiotoxicity in Sprague-Dawley rat assessed as decrease in mean arterial blood pressure at 0.1 mg/kg, iv measured up to 1000 seconds | Rattus norvegicus | 2 | ALA4732177 | organism-based format | Scientific Literature | |
| 18. | ALA4737189 | T | Cardiotoxicity in Sprague-Dawley rat assessed as induction of hypertension at 1 mg/kg, iv measured up to 1000 seconds | Rattus norvegicus | 1 | ALA4732177 | organism-based format | Scientific Literature | |
| 19. | ALA4737191 | A | Induction of hypothermia in Sprague-Dawley rat assessed as reduction in body temperature at 150 microg/kg, IT measured every 10 mins upto 60 mins by thermistor probe analysis | Rattus norvegicus | 1 | ALA4732177 | assay format | Scientific Literature | |
| 20. | ALA4737192 | A | Myorelaxant activity in Sprague-Dawley rat ileum assessed as reduction in carbachol-induced contractions at 10 ^-11 to 10^-5 M by force transducer relaxation assay | Rattus norvegicus | 1 | ALA4732177 | tissue-based format | Scientific Literature |
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