# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4703000 | ADME | Half life in human plasma at 400 uM by HPLC analysis | Homo sapiens | 17 | ALA4699534 | cell-free format | Scientific Literature | |
2. | ALA4703001 | ADME | Half life in mouse plasma at 400 uM by HPLC analysis | Mus musculus | 4 | ALA4699534 | cell-free format | Scientific Literature | |
3. | ALA4703002 | Functional | Activation of APJ receptor (unknown origin) expressed in Chem-5 cells assessed as stimulation of Ca2+ mobilization by Calcium 6-GF dye based fluorescence based assay | Homo sapiens | 21 | ALA4699534 | cell-based format | Scientific Literature | |
4. | ALA4703003 | Functional | Activation of APJ receptor (unknown origin) expressed in Chem-5 cells assessed as stimulation of Ca2+ mobilization by Calcium 6-GF dye based fluorescence based assay relative to Apelin-17 | Homo sapiens | 20 | ALA4699534 | cell-based format | Scientific Literature | |
5. | ALA4703004 | Binding | Displacement of [125I]-pyr-1-apelin-13 from EGFP-tagged wild-type rat apelin receptor expressed in CHO cell membranes by gamma counting method | Rattus norvegicus | 25 | ALA4699534 | cell membrane format | Scientific Literature | |
6. | ALA4703005 | Functional | Cardioprotective activity in C57BL/6 mouse assessed as reduction in mean arterial blood pressure at 1.4 uM/kg, iv measured after 15 mins relative to control | Mus musculus | 21 | ALA4699534 | organism-based format | Scientific Literature | |
7. | ALA4703006 | ADME | Protein binding in 55% human plasma at 100 uM incubated for 3 hrs by LC/MS detection based equilibrium dialysis | Homo sapiens | 5 | ALA4699534 | cell-free format | Scientific Literature | |
8. | ALA4703007 | ADME | Protein binding in 55% mouse plasma at 100 uM incubated for 3 hrs by LC/MS detection based equilibrium dialysis | Mus musculus | 5 | ALA4699534 | cell-free format | Scientific Literature | |
9. | ALA4703008 | Physicochemical | Lipophilicity, log D of the compound in pH 7.4 PBS by LC/MS detection based shake flask assay | 5 | ALA4699534 | small-molecule physicochemical format | Scientific Literature | ||
10. | ALA4703009 | Functional | Cardioprotective activity in mouse Langendorff heart perfusion and ischemia-reperfusion injury model assessed as left ventricle developed pressure at 1 uM dosed at start of reperfusion for 10 mins | Mus musculus | 4 | ALA4699534 | organism-based format | Scientific Literature | |
11. | ALA4703010 | Functional | Cardioprotective activity in mouse Langendorff heart perfusion and ischemia-reperfusion injury model assessed as maximum derivative of change in systolic blood pressure over time at 1 uM dosed at start of reperfusion for 10 mins | Mus musculus | 4 | ALA4699534 | organism-based format | Scientific Literature |