# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4677596 | Binding | Inhibition of recombinant N-terminal GST-fused human NIK (319 to 947 residues) expressed in baculovirus expression system incubated for 120 mins in presence of ATP by ADP-glo based luminescence assay | Homo sapiens | 13 | ALA4673294 | assay format | Scientific Literature | |
2. | ALA4677598 | Functional | Antiinflammatory activity in mouse J774 cells assessed as inhibition of LPS-induced NO production at 1 uM preincubated for 2 hrs followed by LPS stimulation and measured after 22 hrs by Griess reagent based assay relative to control | Mus musculus | 7 | ALA4673294 | cell-based format | Scientific Literature | |
3. | ALA4677599 | Functional | Antiinflammatory activity in mouse T cells assessed as inhibition of ConA-induced induced T cell proliferation at 2 uM incubated for 48 hrs by CCK8 assay relative to control | Mus musculus | 7 | ALA4673294 | cell-based format | Scientific Literature | |
4. | ALA4677600 | Functional | Antiinflammatory activity in mouse T cells assessed as inhibition of ConA-induced induced T cell proliferation at 0.4 uM incubated for 48 hrs by CCK8 assay relative to control | Mus musculus | 7 | ALA4673294 | cell-based format | Scientific Literature | |
5. | ALA4677603 | ADME | Cytotoxicity against mouse T cells assessed as cell growth inhibition at 10 uM after 48 hrs by CCK8 assay | Mus musculus | 4 | ALA4673294 | cell-based format | Scientific Literature |