# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4719445 | A | Substrate activity at COMT (unknown origin) assessed as N-(2-Fluoro-4,5-dimethoxyphenethyl)octanamide formation in presence of cofactor SAM at 180 mins by HPLC analysis | Homo sapiens | 2 | single protein format | Scientific Literature | ||
2. | ALA4719446 | A | Substrate activity at COMT (unknown origin) assessed as N-(4-Hydroxy-3-methoxyphenethyl)octanamide formation in presence of cofactor SAM at 180 mins by HPLC analysis | Homo sapiens | 2 | single protein format | Scientific Literature | ||
3. | ALA4719453 | F | Antiinflammatory activity in HUVEC assessed as inhibition of TNFalpha-stimulated VCAM1 expression at higher concentration measured after overnight incubation by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
4. | ALA4719454 | F | Antiinflammatory activity in HUVEC assessed as inhibition of TNFalpha-stimulated VCAM1 expression at lower concentration measured after overnight incubation by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
5. | ALA4719455 | B | Activation of NRF2 in HUVEC assessed as induction of HO1 expression at lower concentration measured after overnight incubation by Western blot analysis | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
6. | ALA4719456 | B | Activation of NRF2 in HUVEC assessed as induction of HO1 expression at higher concentration measured after overnight incubation by Western blot analysis | Homo sapiens | 2 | tissue-based format | Scientific Literature | ||
7. | ALA4719457 | P | Redox activity of compound assessed as quenching of luminescence by horseradish peroxidase coupled luminol assay | 2 | small-molecule physicochemical format | Scientific Literature | |||
8. | ALA4719458 | B | Activation of rat TRPV1 transfected in HEK293 cells assessed as increase in calcium influx in presence of capsaicin by FURA-2-AM dye based fluorescence assay | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
9. | ALA4719459 | F | Protection against cold inflicted injury in HUVEC assessed as 25 to 100 uM pretreated for 2 hrs followed by washout and subsequent incubation for 20 hrs at 4 degC by LDH assay | Homo sapiens | 2 | cell-based format | Scientific Literature |