# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4704510 | Functional | Antiviral activity against GFP-fused Human adenovirus 5 infected in 293beta5 cells assessed as inhibition of plaque formation incubated for 7 days by GFP reporter gene assay | Human adenovirus 5 | 68 | ALA4699598 | organism-based format | Scientific Literature | |
2. | ALA4704511 | ADME | Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by alamarBlue assay | Homo sapiens | 68 | ALA4699598 | cell-based format | Scientific Literature | |
3. | ALA4704512 | Toxicity | Selectivity index, ratio of CC50 for cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by alamarBlue assay to IC50 for antiviral activity against Human adenovirus 5 infected in 293beta5 cells assessed as inhibition of plaque formation incubated for 7 days by GFP reporter gene assay | 68 | ALA4699598 | cell-based format | Scientific Literature | ||
4. | ALA4704513 | Functional | Antiviral activity against Human adenovirus 5 infected in 293beta5 cells assessed as inhibition of plaque formation at 10 uM incubated for 7 days by GFP reporter gene assay relative to control | Human adenovirus 5 | 66 | ALA4699598 | organism-based format | Scientific Literature | |
5. | ALA4704514 | Functional | Antiviral activity against WT-Human adenovirus 5 infected in A549 cells assessed as fold reduction in virus yield at 10 fold of IC50 after 48 hrs endpoint dilution method | Human adenovirus 5 | 9 | ALA4699598 | organism-based format | Scientific Literature | |
6. | ALA4704515 | Functional | Antiviral activity against wild-type Human adenovirus 5 infected in human A549 cells assessed as inhibition of virus entry incubated for 48 hrs by fluorescence assay | Human adenovirus 5 | 9 | ALA4699598 | organism-based format | Scientific Literature | |
7. | ALA4704516 | Functional | Antiviral activity against wild-type Human adenovirus 5 infected in human A549 cells assessed as inhibition of virus entry at 50 uM incubated for 48 hrs by fluorescence assay relative to control | Human adenovirus 5 | 9 | ALA4699598 | organism-based format | Scientific Literature | |
8. | ALA4704517 | Functional | Antiviral activity against wild-type Human adenovirus 5 infected in human A549 cells assessed as inhibition of viral entry by measuring nuclear associated viral genome level at 10 fold IC50 incubated for 45 mins by RT-PCR analysis (Rvb = 100 +/- 1.07 %) | Human adenovirus 5 | 8 | ALA4699598 | organism-based format | Scientific Literature | |
9. | ALA4704522 | Functional | Antiviral activity against Human adenovirus 5 infected in 293beta5 cells assessed as inhibition of virus infection at 10 fold of IC50 measured at 0 min by GFP reporter gene assay relative to control | Human adenovirus 5 | 3 | ALA4699598 | organism-based format | Scientific Literature | |
10. | ALA4704527 | Functional | Antiviral activity against wild-type Human adenovirus 5 infected in human A549 cells assessed as inhibition of viral DNA replication by measuring number of viral DNA copies at 9 uM after 24 hrs by RT-qPCR analysis (Rvb = 100 +/- 0.16 %) | Human adenovirus 5 | 1 | ALA4699598 | organism-based format | Scientific Literature | |
11. | ALA4704533 | Functional | Antiviral activity against human cytomegalovirus infected in HFF cells assessed as inhibition of viral replication by measuring number of viral DNA copies at 9 uM incubated for 72 hrs by RT-PCR analysis (Rvb = 100 +/- 25.56 %) | Human betaherpesvirus 5 | 1 | ALA4699598 | cell-based format | Scientific Literature |