| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4687013 | F | Inhibition of TGF-beta-induced collagen accumulation in rat NRK-49F cells at 10 uM incubated for 2 days by PSR staining based microscopic analysis relative to control | Rattus norvegicus | 61 | cell-based format | Scientific Literature | ||
| 2. | ALA4687014 | A | Cytotoxicity against rat NRK-49F cells assessed as cell survival rate at 10 uM incubated for 72 hrs by MTT assay | Rattus norvegicus | 61 | cell-based format | Scientific Literature | ||
| 3. | ALA4687016 | F | Antimigratory activity in mouse L929 cells assessed as inhibition of TGF-beta-induced cell migration at 10 uM incubated for 24 hrs by wound healing assay | Mus musculus | 6 | cell-based format | Scientific Literature | ||
| 4. | ALA4687017 | F | Inhibition of TGF-beta-induced collagen-1 protein expression in rat NRK-49F cells at 20 to 40 uM incubated for 24 hrs by Western blotting analysis | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
| 5. | ALA4687018 | F | Inhibition of TGF-beta-induced alpha-SMA protein expression in rat NRK-49F cells at 20 to 40 uM incubated for 24 hrs by Western blotting analysis | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
| 6. | ALA4687019 | B | Inhibition of TGF-beta induced SMAD2 phosphorylation in rat NRK-49F cells at 20 to 40 uM pretreated with compound for 1 to 2 hrs followed by TGF-beta stimulation for 1 hr by Western blot analysis | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4687020 | B | Inhibition of TGF-beta induced SMAD3 phosphorylation in rat NRK-49F cells at 20 to 40 uM pretreated with compound for 1 to 2 hrs followed by TGF-beta stimulation for 1 hr by Western blot analysis | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4687021 | B | Inhibition of TGF-beta induced ERK1/2 phosphorylation in rat NRK-49F cells at 20 to 40 uM pretreated with compound for 1 to 2 hrs followed by TGF-beta stimulation for 1 hr by Western blot analysis | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4687022 | B | Inhibition of TGF-beta induced p38 phosphorylation in rat NRK-49F cells at 20 to 40 uM pretreated with compound for 1 to 2 hrs followed by TGF-beta stimulation for 1 hr by Western blot analysis | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4687023 | A | Tmax in Sprague-Dawley rat at 5 mg/kg, iv | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 11. | ALA4687024 | A | Tmax in Sprague-Dawley rat at 5 mg/kg, po | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA4687025 | A | Half life in Sprague-Dawley rat at 5 mg/kg, iv | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA4687026 | A | Half life in Sprague-Dawley rat at 5 mg/kg, po | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA4687027 | A | AUC (0 to t) in Sprague-Dawley rat at 5 mg/kg, iv | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA4687028 | A | AUC (0 to t) in Sprague-Dawley rat at 5 mg/kg, po | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA4687029 | A | Oral bioavailability in Sprague-Dawley rat at 5 mg/kg | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 17. | ALA4687030 | F | Anti-fibrotic activity in C57BL/6 mouse model of bleomycin-induced lung fibrosis assessed as reduction in collagen deposition by measuring hydroxyproline content in lung at 50 to 100 mg/kg, po administered for 30 days starting from day 1 post bleomycin treatment | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA4687032 | F | Anti-fibrotic activity in C57BL/6 mouse model of bleomycin-induced lung fibrosis assessed as reduction in collagen deposition by measuring hydroxyproline content in lung at 100 mg/kg, po administered for 21 days starting from day 8 post bleomycin treatment | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA4687034 | F | Anti-fibrotic activity in C57BL/6 mouse model of bleomycin-induced lung fibrosis assessed as survival rate at 50 to 100 mg/kg, po administered for 30 days starting from day 1 post bleomycin treatment | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA4687036 | F | Anti-fibrotic activity in C57BL/6 mouse model of bleomycin-induced lung fibrosis assessed as survival rate at 50 mg/kg, po administered for 21 days starting from day 8 post bleomycin treatment | Mus musculus | 1 | organism-based format | Scientific Literature |
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