| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4709980 | B | Binding affinity to wild-type human partial length RET (E713 to D1014 residues) expressed in bacterial expression system assessed as residual binding level at 1 uM by kinomescan method relative to control | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 2. | ALA4709981 | B | Inhibition of CCDC6-RET fusion protein (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation measured after 48 hrs by MTS assay | Homo sapiens | 38 | cell-based format | Scientific Literature | ||
| 3. | ALA4709982 | B | Inhibition of KIF5B-RET fusion protein (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation measured after 48 hrs by MTS assay | Homo sapiens | 38 | cell-based format | Scientific Literature | ||
| 4. | ALA4709985 | B | Inhibition of CCDC6-RET V804M mutant fusion protein (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation measured after 48 hrs by MTS assay | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
| 5. | ALA4709986 | B | Inhibition of KIF5B-RET V804M mutant fusion protein (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation measured after 48 hrs by MTS assay | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
| 6. | ALA4709987 | A | Cytotoxicity against mouse BaF3 cells assessed as reduction in cell proliferation measured after 48 hrs by MTS assay | Mus musculus | 12 | cell-based format | Scientific Literature | ||
| 7. | ALA4709988 | B | Inhibition of recombinant wild-type human N-terminal GST-HIS6 fused RET C-terminal domain (H658 to S1114 residues) expressed in Sf9 insect cells using TRK-C-derived peptide as substrate in presence of [33P]-ATP by filter binding assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 8. | ALA4709989 | B | Inhibition of recombinant human N-terminal GST-HIS6 fused RET M918T mutant C-terminal domain (H658 to S1114 residues) expressed in Sf9 insect cells using TRK-C-derived peptide as substrate in presence of [33P]-ATP by filter binding assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 9. | ALA4709990 | B | Inhibition of recombinant human N-terminal GST-HIS6 fused RET V804L mutant C-terminal domain (H658 to S1114 residues) expressed in Sf9 insect cells using TRK-C-derived peptide as substrate in presence of [33P]-ATP by filter binding assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 10. | ALA4709991 | B | Inhibition of recombinant human N-terminal GST-HIS6 fused RET V804M mutant C-terminal domain (H658 to S1114 residues) expressed in Sf9 insect cells using TRK-C-derived peptide as substrate in presence of [33P]-ATP by filter binding assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 11. | ALA4709992 | B | Inhibition of human N-terminal GST-HIS6 fused CCDC6-RET fusion protein (Met1 to Ser503 residues) expressed in Sf9 insect cells using TRK-C-derived peptide as substrate in presence of [33P]-ATP by filter binding assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 12. | ALA4709993 | B | Inhibition of KIF5B-RET fusion protein (unknown origin) by radiometric assay | Homo sapiens | 2 | protein format | Scientific Literature | ||
| 13. | ALA4709994 | B | Binding affinity to wild-type human partial length RET M918T mutant (E713 to D1014 residues) expressed in bacterial expression system assessed as residual binding level at 1 uM by kinomescan method relative to control | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 14. | ALA4709995 | B | Binding affinity to wild-type human partial length RET V804L mutant (E713 to D1014 residues) expressed in bacterial expression system assessed as residual binding level at 1 uM by kinomescan method relative to control | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 15. | ALA4709996 | B | Binding affinity to wild-type human partial length RET V804M mutant (E713 to D1014 residues) expressed in bacterial expression system assessed as residual binding level at 1 uM by kinomescan method relative to control | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 16. | ALA4709997 | B | Inhibition of CCDC6-RET fusion protein in human LC-2-ad cells assessed as reduction in cell proliferation measured after 48 hrs by MTS assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4709998 | F | Antiproliferative activity against human A549 cells measured after 48 hrs by MTS assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA4709999 | F | Antiproliferative activity against human NCI-H3122 cells measured after 48 hrs by MTS assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA4710000 | F | Antiproliferative activity against human MDA-MB-231 cells measured after 48 hrs by MTS assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA4710001 | F | Antiproliferative activity against human A-375 cells measured after 48 hrs by MTS assay | Homo sapiens | 1 | cell-based format | Scientific Literature |
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