Antitumor activity against human AMO1 cells xenografted in CB-17 SCID mouse assessed as time to reach tumor volume of 500 mm3 at 25 mg/kg, iv administered as bolus dose for 5 consecutive days
Antitumor activity against human AMO1 cells xenografted in CB-17 SCID mouse assessed as time to reach tumor volume of 500 mm3 at 50 mg/kg, iv administered as bolus dose for 5 consecutive days
Antitumor activity against human AMO1 xenografted in CB-17 SCID mouse assessed as tumor growth suppression at 50 mg/kg, iv administered for 5 consecutive days measured after 5 weeks
Antitumor activity against human AMO1 xenografted in CB-17 SCID mouse assessed as tumor growth suppression at 25 mg/kg, iv administered for 5 consecutive days and measured post-last dose
Antitumor activity against human AMO1 cells xenografted in CB-17 SCID mouse assessed as maximum tumor growth inhibition at 50 mg/kg, iv administered as bolus dose for 5 consecutive days measured on day 2 relative to control
Antitumor activity against human AMO1 cells xenografted in CB-17 SCID mouse assessed as maximum tumor growth inhibition at 25 mg/kg, iv administered as bolus dose for 5 consecutive days measured on day 2 relative to control
Antitumor activity against human AMO1 cells xenografted in CB-17 SCID mouse assessed as tumor growth inhibition at 50 mg/kg, iv for 5 days measured on day 7 relative to control
Antitumor activity against human AMO1 cells xenografted in CB-17 SCID mouse assessed as tumor growth inhibition at 25 mg/kg, iv for 5 days measured on day7 relative to control
Induction of apoptosis in human AMO1 cells xenografted in CB-17 SCID mouse assessed as increase in cleaved PARP level at 25 to 50 mg/kg, iv administered as bolus dose measured after 30 hrs by immunodetection analysis
Induction of apoptosis in human AMO1 cells xenografted in CB-17 SCID mouse assessed as increase in cleaved PARP level administered intravenously as bolus dose measured after 6 to 16 hrs by immunodetection analysis
Induction of apoptosis in human AMO1 cells xenografted in CB-17 SCID mouse assessed as increase in cleaved PARP level at 25 to 50 mg/kg, iv administered as bolus dose measured after 6 hrs by immunodetection analysis
Inhibition of C-terminal TQ5WS-labelled QWAREIGAQLRRMADDLNAQY binding to human C-terminal Cy5-labelled Mcl-1 V321C/C286S mutant (171 to 321 residue) incubated for 2 hrs by fluorescence polarization analysis