# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4710646 | Binding | Inhibition of human BChE using butyrylthiocholineiodide as substrate measured for 5 mins by Ellman's method | Homo sapiens | 14 | ALA4706571 | single protein format | Scientific Literature | |
2. | ALA4710647 | Binding | Inhibition of human AChE assessed as residual activity at 100 uM using acetylthiocholine iodide as substrate measured for 5 mins by Ellman's method | Homo sapiens | 11 | ALA4706571 | single protein format | Scientific Literature | |
3. | ALA4710649 | Functional | Anti-amnesic activity in CD-1 mouse model of scopolamine-induced memory impairment assessed as step-through latency time to enter dark compartment in retention trail on day 2 at 10 to 30 mg/kg, ip administered 60 mins before trail by passive avoidance test | Mus musculus | 1 | ALA4706571 | organism-based format | Scientific Literature | |
4. | ALA4710650 | Functional | Cognitive enhancing effect in C57BL/6J mouse model of scopolamine-induced memory impairment model assessed as escape latency time at 10 to 30 mg/kg, ip administered for 7 days and 60 mins before trail by Morris water maze test relative to control | Mus musculus | 1 | ALA4706571 | organism-based format | Scientific Literature | |
5. | ALA4710651 | Functional | Cognitive enhancing effect in intraperitoneally dosed C57BL/6J mouse model of scopolamine-induced memory impairment assessed as enhancement of long-term memory retrieval by measuring latency time to find former escape box location in acquisition phase measured on day 12 by Barnes maze test | Mus musculus | 1 | ALA4706571 | organism-based format | Scientific Literature | |
6. | ALA4710652 | Toxicity | Neurotoxicity in mouse assessed as effect in locomotor activity at 30 mg/kg, ip measured up to 60 mins by rotarod test | Mus musculus | 1 | ALA4706571 | organism-based format | Scientific Literature | |
7. | ALA4710653 | Functional | Cognitive enhancing effect in intraperitoneally dosed C57BL/6J mouse model of scopolamine-induced memory impairment assessed as enhancement of learning abilities and working memory by measuring escape latency time to reach target in acquisition phase measured on day 5 by Barnes maze test | Mus musculus | 1 | ALA4706571 | organism-based format | Scientific Literature | |
8. | ALA4710654 | Functional | Cognitive enhancing effect in intraperitoneally dosed C57BL/6J mouse model of scopolamine-induced memory impairment assessed as enhancement of short-term memory retrieval by measuring latency time to find former escape box location in acquisition phase measured on day 5 by Barnes maze test | Mus musculus | 1 | ALA4706571 | organism-based format | Scientific Literature |